{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:03:02Z","timestamp":1771020182209,"version":"3.50.1"},"reference-count":60,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Our systematic review aims to compare recurrence rates and complications of biological versus synthetic patches for the repair of congenital diaphragmatic herniae.<\/jats:p><jats:p>\n          Methods\u2003Studies from January 1, 1980 to April 25, 2020, with patients under the age of 16 years and with a minimum 6-month follow-up, were included from MEDLINE, Embase, and Cochrane databases. Funnel plots for recurrence rates were constructed for biological and synthetic patches. Subgroup analysis was performed for recurrence rate at the 1-year time-point and data were gathered on individual adverse events from relevant studies.<\/jats:p><jats:p>\n          Results\u2003A total of 47 studies with 986 patients (226 biological, 760 synthetic) were included. Funnel plot analysis determined overall recurrence rates of 16.7% for synthetic and 30.3% for biological patches. Subgroup analysis of 493 and 146 patients with synthetic and biological patches, respectively, showed recurrence rates of 9.9 and 26%, respectively.<\/jats:p><jats:p>The most commonly used patch types\u2014PTFE (polytetrafluoroethylene) and SIS (small intestinal submucosa)\u2014had 11.5 and 33.3% recurrence, respectively. Adhesive bowel obstruction rates ranged from 4 to 29% in studies that systematically reported it for synthetic, and 7 to 35% for biological patches. Gastroesophageal reflux rates ranged from 25 to 48% in studies that systematically reported it for synthetic, and 21 to 42% for biological patches. Pectus deformity rates were reported as high as 80% for synthetic patches.<\/jats:p><jats:p>\n          Conclusion\u2003Biological patches appear to have higher recurrence rates than synthetic patches, while skeletal deformities are associated more commonly with synthetic patches. Results of biological patches are mainly using SIS and this may overestimate complications of current superior biological patches.<\/jats:p>","DOI":"10.1055\/s-0042-1748530","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T22:39:20Z","timestamp":1661553560000},"page":"198-209","source":"Crossref","is-referenced-by-count":5,"title":["Synthetic versus Biological Patches for CDH: A Comparison of Recurrence Rates and Adverse Events, Systematic Review, and Meta-Analysis"],"prefix":"10.1055","volume":"33","author":[{"given":"Tasnim Rowshan","family":"Kamal","sequence":"additional","affiliation":[{"name":"Medical Science Division, Green Templeton College, University of Oxford, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Tyraskis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmit","family":"Ghattaura","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Fitchie","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokila","family":"Lakhoo","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/tera.1420460605","article-title":"A population-based study of congenital diaphragmatic hernia","volume":"46","author":"C P Torfs","year":"1992","journal-title":"Teratology"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1053\/jpsu.2000.8725","article-title":"Congenital diaphragmatic hernia: a meta-analysis of mortality factors","volume":"35","author":"H Skari","year":"2000","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"e651","DOI":"10.1542\/peds.2006-3040","article-title":"Defect size determines survival in infants with congenital diaphragmatic hernia","volume":"120","author":"K P Lally","year":"2007","journal-title":"Pediatrics"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0022-3468(98)90522-X","article-title":"Current surgical management of congenital diaphragmatic hernia: a report from the Congenital Diaphragmatic Hernia Study Group","volume":"33","author":"R H Clark","year":"1998","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jpedsurg.2005.10.005","article-title":"Prosthetic patches for congenital diaphragmatic hernia repair: Surgisis vs Gore-Tex","volume":"41","author":"E J Grethel","year":"2006","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpedsurg.2009.10.028","article-title":"Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution","volume":"45","author":"T Jancelewicz","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jpedsurg.2005.07.007","article-title":"Implantation of a cone-shaped double-fixed patch increases abdominal space and prevents recurrence of large defects in congenital diaphragmatic hernia","volume":"40","author":"S Loff","year":"2005","journal-title":"J Pediatr Surg"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1136\/archdischild-2018-316396","article-title":"One-year outcomes of infants born with congenital diaphragmatic hernia: a national population cohort study","volume":"104","author":"A M Long","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/bjs.9306","article-title":"Outcomes following prosthetic patch repair in newborns with congenital diaphragmatic hernia","volume":"100","author":"W B Jawaid","year":"2013","journal-title":"Br J Surg"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0034-1394155","article-title":"Biologic versus synthetic mesh reinforcement: what are the pros and cons?","volume":"27","author":"J F FitzGerald","year":"2014","journal-title":"Clin Colon Rectal Surg"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.24075\/brsmu.2016-05-02","article-title":"The use of implants for surgical treatment of congenital diaphragmatic hernia in newborns","author":"AYu Razumovskly","year":"2016","journal-title":"Bulletin of RSMU."},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jpedsurg.2013.02.005","article-title":"Late surgical outcomes among congenital diaphragmatic hernia (CDH) patients: why long-term follow-up with surgeons is recommended","volume":"48","author":"T Jancelewicz","year":"2013","journal-title":"J Pediatr Surg"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-0030-1261939","article-title":"Outcome of congenital diaphragmatic hernia repair depending on patch type","volume":"20","author":"C Laituri","year":"2010","journal-title":"Eur J Pediatr Surg"},{"issue":"08","key":"ref14","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.jpedsurg.2012.01.009","article-title":"What is the best prosthetic material for patch repair of congenital diaphragmatic hernia? Comparison and meta-analysis of porcine small intestinal submucosa and polytetrafluoroethylene","volume":"47","author":"R L Romao","year":"2012","journal-title":"J Pediatr Surg"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.jpedsurg.2008.08.040","article-title":"Permacol: a potential biologic patch alternative in congenital diaphragmatic hernia repair","volume":"43","author":"I C Mitchell","year":"2008","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpedsurg.2011.10.023","article-title":"Split abdominal wall muscle flap repair vs patch repair of large congenital diaphragmatic hernias","volume":"47","author":"D C Barnhart","year":"2012","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpedsurg.2009.10.024","article-title":"Outcomes after muscle flap vs prosthetic patch repair for large congenital diaphragmatic hernias","volume":"45","author":"A Nasr","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jpedsurg.2011.11.054","article-title":"Patch repair for congenital diaphragmatic hernia: is it really a problem?","volume":"47","author":"J Tsai","year":"2012","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.21699\/jns.v5i3.423","article-title":"Erratum: Thoracoscopic patch repair of congenital diaphragmatic hernia in a neonate using spiral tacks: a case report","volume":"5","author":"M A Riquelme","year":"2016","journal-title":"J Neonatal Surg"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.jpedsurg.2007.07.009","article-title":"Low recurrence rate after Gore-Tex\/Marlex composite patch repair for posterolateral congenital diaphragmatic hernia","volume":"42","author":"K J Riehle","year":"2007","journal-title":"J Pediatr Surg"},{"issue":"36","key":"ref21","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.14260\/jemds\/2015\/918","article-title":"A delayed presentation of right sided congenital diaphragmatic hernia with right lower lobe hypoplasia","volume":"4","author":"A Premkumar","year":"2015","journal-title":"J Evol Med Dent Sci"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1055\/s-0037-1612618","article-title":"Use of nonabsorbable spiral tacks for mesh reinforcement in thoracoscopic repair of congenital diaphragmatic hernia","volume":"6","author":"A Poupalou","year":"2018","journal-title":"European J Pediatr Surg Rep"},{"issue":"07","key":"ref23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0022-3468(92)90386-L","article-title":"Pathophysiology of congenital diaphragmatic hernia. III: exogenous surfactant therapy for the high-risk neonate with CDH","volume":"27","author":"P L Glick","year":"1992","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-2008-1066490","article-title":"Prosthetic patches used to close congenital diaphragmatic defects behave well: a long-term follow-up study","volume":"6","author":"L M de Kort","year":"1996","journal-title":"Eur J Pediatr Surg"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/2193-1801-3-165","article-title":"Laparoscopic patch repair of recurrent anterior diaphragmatic hernia in a child with SMA","volume":"3","author":"N Cantone","year":"2014","journal-title":"Springerplus"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s004640090064","article-title":"Thoracoscopic treatment for delayed presentation of congenital diaphragmatic hernia in the infant. A report of three cases","volume":"15","author":"F Becmeur","year":"2001","journal-title":"Surg Endosc"},{"issue":"09","key":"ref27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00383-014-3575-x","article-title":"Surgical complications, especially gastroesophageal reflux disease, intestinal adhesion obstruction, and diaphragmatic hernia recurrence, are major sequelae in survivors of congenital diaphragmatic hernia","volume":"30","author":"K Yokota","year":"2014","journal-title":"Pediatr Surg Int"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1007\/s00268-020-05387-4","article-title":"Surgical complications in children with CDH: a multivariate analysis","volume":"44","author":"K Heiwegen","year":"2020","journal-title":"World J Surg"},{"issue":"06","key":"ref29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/lap.2007.0239","article-title":"Thoracoscopic repair of neonatal diaphragmatic hernia","volume":"18","author":"Y S Guner","year":"2008","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jpedsurg.2017.05.032","article-title":"Factors related to long-term surgical morbidity in congenital diaphragmatic hernia survivors","volume":"53","author":"S Janssen","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0022-3468(95)90598-7","article-title":"Outcome for infants with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation: the first year","volume":"30","author":"J A D'Agostino","year":"1995","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10029-012-0906-5","article-title":"Late-presenting congenital diaphragmatic hernia: diagnostic pitfalls and outcome","volume":"16","author":"J Baerg","year":"2012","journal-title":"Hernia"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.epsc.2014.09.008","article-title":"In need of a patch UP: recurrent congenital diaphragmatic hernia presenting with a large pleural effusion","volume":"2","author":"F Shariff","year":"2014","journal-title":"J Pediatr Surg Case Rep"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00383-004-1298-0","article-title":"The SIS extracellular matrix scaffold-preliminary results of use in congenital diaphragmatic hernia (CDH) repair","volume":"20","author":"M J Smith","year":"2004","journal-title":"Pediatr Surg Int"},{"issue":"02","key":"ref35","first-page":"107","article-title":"Preserved dura and pericardium for closure of large abdominal wall and diaphragmatic defects in children","volume":"67","author":"J M Hutson","year":"1985","journal-title":"Ann R Coll Surg Engl"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/lap.2006.0059","article-title":"Successful repair of a diaphragmatic hernia through a pericardial window with acellular dermal matrix","volume":"17","author":"K Bruen","year":"2007","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.jpedsurg.2019.08.042","article-title":"Flap repair in congenital diaphragmatic hernia leads to lower rates of recurrence","volume":"54","author":"L Dewberry","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00383-011-2973-6","article-title":"Large diaphragmatic defect: are skeletal deformities preventable?","volume":"27","author":"P Kuklov\u00e1","year":"2011","journal-title":"Pediatr Surg Int"},{"issue":"06","key":"ref39","first-page":"500","article-title":"Long-term follow-up of children with congenital diaphragmatic hernia\u2013observations from a single institution","volume":"24","author":"M Koziarkiewicz","year":"2014","journal-title":"Eur J Pediatr Surg"},{"issue":"06","key":"ref40","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jpedsurg.2014.01.018","article-title":"Musculoskeletal deformities following repair of large congenital diaphragmatic hernias","volume":"49","author":"K W Russell","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jpedsurg.2009.10.090","article-title":"Hepatic pulmonary fusion in an infant with a right-sided congenital diaphragmatic hernia and contralateral mediastinal shift","volume":"45","author":"J W Gander","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1440-1754.2002.00820.x","article-title":"Fryns syndrome: a surviving case with associated Hirschsprung's disease and hemidiaphragmatic agenesis","volume":"38","author":"C Davis","year":"2002","journal-title":"J Paediatr Child Health"},{"issue":"09","key":"ref43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.15537\/smj.2019.9.24378","article-title":"Surgical repair of bilateral congenital diaphragmatic hernia associated with hepatopulmonary fusion","volume":"40","author":"O A Bawazir","year":"2019","journal-title":"Saudi Med J"},{"issue":"07","key":"ref44","first-page":"221","article-title":"Congenital bilateral diaphragmatic eventration\u2013a rare anomaly with complicated perioperative care","volume":"48","author":"Z Ahmed","year":"1998","journal-title":"J Pak Med Assoc"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1089\/lap.2016.0358","article-title":"A multi-institutional review of thoracoscopic congenital diaphragmatic hernia repair","volume":"26","author":"K L Weaver","year":"2016","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"06","key":"ref46","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00464-008-0143-2","article-title":"Minimally invasive congenital diaphragmatic hernia repair: a 7-year review of one institution's experience","volume":"23","author":"S R Shah","year":"2009","journal-title":"Surg Endosc"},{"issue":"02","key":"ref47","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jpedsurg.2009.10.072","article-title":"Thoracoscopic repair of congenital diaphragmatic hernia: intraoperative ventilation and recurrence","volume":"45","author":"M McHoney","year":"2010","journal-title":"J Pediatr Surg"},{"issue":"05","key":"ref48","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/0022-3468(93)90027-I","article-title":"Lyophylized dura patch repair of congenital diaphragmatic hernia: occurrence of relapses","volume":"28","author":"V C Koot","year":"1993","journal-title":"J Pediatr Surg"},{"issue":"11","key":"ref49","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.jpedsurg.2018.04.007","article-title":"Risk factors for recurrence after thoracoscopic repair of congenital diaphragmatic hernia (CDH)","volume":"53","author":"A Kamran","year":"2018","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jpedsurg.2008.10.013","article-title":"Analysis of 29 consecutive thoracoscopic repairs of congenital diaphragmatic hernia in neonates compared to historical controls","volume":"44","author":"S D Cho","year":"2009","journal-title":"J Pediatr Surg"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00383-020-04634-y","article-title":"When primary repair is not enough: a comparison of synthetic patch and muscle flap closure in congenital diaphragmatic hernia?","volume":"36","author":"E Ayd\u0131n","year":"2020","journal-title":"Pediatr Surg Int"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00383-012-3113-7","article-title":"Defect-diaphragmatic ratio: a new parameter for assessment of defect size in neonates with congenital diaphragmatic hernia","volume":"28","author":"M Rygl","year":"2012","journal-title":"Pediatr Surg Int"},{"issue":"06","key":"ref53","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1177\/0885328216676757","article-title":"New insight in the biological integration of polytetrafluoroethylene from an explant used for diaphragm repair","volume":"31","author":"A Schneider","year":"2017","journal-title":"J Biomater Appl"},{"issue":"04","key":"ref54","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1111\/apa.12144","article-title":"Detection of immediate post-operative abdominal compartment after congenital diaphragmatic hernia closure","volume":"102","author":"E M Ruttenstock","year":"2013","journal-title":"Acta Paediatr"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/jsre.2001.6176","article-title":"Strength over time of a resorbable bioscaffold for body wall repair in a dog model","volume":"99","author":"S Badylak","year":"2001","journal-title":"J Surg Res"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1553350609331397","article-title":"Are biologic grafts effective for hernia repair?: a systematic review of the literature","volume":"16","author":"M Hiles","year":"2009","journal-title":"Surg Innov"},{"issue":"02","key":"ref58","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jss.2007.03.018","article-title":"Abdominal complications related to type of repair for congenital diaphragmatic hernia","volume":"140","author":"S D St Peter","year":"2007","journal-title":"J Surg Res"},{"issue":"09","key":"ref59","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.jpedsurg.2008.11.030","article-title":"Beyond feasibility: a comparison of newborns undergoing thoracoscopic and open repair of congenital diaphragmatic hernias","volume":"44","author":"D M Gourlay","year":"2009","journal-title":"J Pediatr Surg"},{"issue":"05","key":"ref60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10029-006-0130-2","article-title":"Ventral herniorrhaphy: experience with two different biosynthetic mesh materials, Surgisis and Alloderm","volume":"10","author":"A Gupta","year":"2006","journal-title":"Hernia"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.prs.0000220470.97776.f5","article-title":"Use of regenerative human acellular tissue (AlloDerm) to reconstruct the abdominal wall following pedicle TRAM flap breast reconstruction surgery","volume":"118","author":"S B Glasberg","year":"2006","journal-title":"Plast Reconstr Surg"}],"container-title":["European Journal of Pediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1748530.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T23:08:00Z","timestamp":1684278480000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1748530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":60,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,5,16]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1748530","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0939-7248","1439-359X"],"issn-type":[{"value":"0939-7248","type":"print"},{"value":"1439-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,26]]}}}