{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:02:40Z","timestamp":1789419760995,"version":"build-2803163510"},"reference-count":111,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Liver cancer incidence rate continues to increase and currently ranks third in the total number of annual deaths, behind only lung and colorectal cancer. Most patients with hepatocellular carcinoma (HCC) are diagnosed at advanced stages, and they live for less than 2 years after diagnosis on average. This contrasts with those diagnosed at an early stage, who can be cured with surgery. However, even after curative resection, there remains a risk of up to 70% of postoperative HCC recurrence. There have been major changes in the management of HCC in the past 5 years, particularly for patients at advanced stages. Despite this multitude of new therapies, there is a lack of clear biomarkers to guide providers on the best approach to sequence therapies, which would maximize efficacy while minimizing toxicity. There are several areas in clinical management of HCC that are particularly challenging, and would benefit from development and implementation of new biomarkers to improve patient overall survival. Here, we review the major advances in liquid biopsy biomarkers for early detection of HCC, minimum residual disease, and predicting response to treatment.<\/jats:p>","DOI":"10.1055\/s-0042-1748924","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:48:46Z","timestamp":1656024526000},"page":"188-201","source":"Crossref","is-referenced-by-count":13,"title":["Biomarker Development Using Liquid Biopsy in Hepatocellular Carcinoma"],"prefix":"10.1055","volume":"42","author":[{"given":"Lauren Tal","family":"Grinspan","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases, Recanati\/Miller Transplantation Institute, The Mount Sinai Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Division of Hematology\/Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"R L Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"15","key":"ref5","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular carcinoma","volume":"380","author":"A Villanueva","year":"2019","journal-title":"N Engl J Med"},{"issue":"07","key":"ref6","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1053\/j.gastro.2021.01.233","article-title":"International Liver Cancer Association (ILCA) white paper on biomarker development for hepatocellular carcinoma","volume":"160","author":"A G Singal","year":"2021","journal-title":"Gastroenterology"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1136\/gutjnl-2019-320282","article-title":"Liquid biopsy in the clinical management of hepatocellular carcinoma","volume":"69","author":"J von Felden","year":"2020","journal-title":"Gut"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cgh.2018.10.031","article-title":"Hepatocellular carcinoma screening is associated with increased survival of patients with cirrhosis","volume":"17","author":"D T Choi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL Clinical Practice Guidelines: management of hepatocellular carcinoma","volume":"69","author":"European Association for the Study of the Liver. 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