{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:51:22Z","timestamp":1780552282670,"version":"3.54.1"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Endocarditis is continuously increasing. Evidence exist that the prognosis is adversely affected by the extent of the disease. We looked at risk factors influencing in-hospital mortality (HM).<\/jats:p><jats:p>\n          Patients and Methods\u2003Between 2010 and 2019, 484 patients, 338 males (69.8%) with mean age of 66.1 years were operated on because of proven endocarditis. In a retrospective study, a risk factor analysis was performed.<\/jats:p><jats:p>\n          Results\u2003Overall HM was 30.17%. Significant influencing factors (odds ratios [ORs] or p-value) for HM were: age (p\u2009=\u20090.004), logistic EuroSCORE (p&lt; 0.001), gender (OR\u2009=\u20091.64), dialysis (OR\u2009=\u20092.64), hepatic insufficiency (OR\u2009=\u20092.17), reoperation (OR\u2009=\u20091.77), previously implanted valve (OR\u2009=\u20091.97), periannular abscess (OR\u2009=\u20099.26), sepsis on admission (OR\u2009=\u200912.88), and number of involved valves (OR\u2009=\u20091.96). Development of a sepsis and HM was significantly lower if Streptococcus mitis was the main pathogen in contrast to other bacteria (p&lt; 0.001). Staphylococcus aureus was significantly more often found in patients with a previously implanted prosthesis (p\u2009=\u20090.03) and in recurrent endocarditis (p\u2009=\u20090.02), while it significantly more often showed peripheral septic emboli than the other pathogens (p&lt; 0.001).<\/jats:p><jats:p>\n          Conclusion\u2003Endocarditis remains life-threatening. Severe comorbidities adversely affected early outcome, particularly, in presence of periannular abscesses. Patients with suspected endocarditis should be admitted to a specialized heart center as early as possible. Streptococcus mitis appears to be less virulent than S. aureus. Further studies are required to verify these findings.<\/jats:p>","DOI":"10.1055\/s-0042-1748950","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T23:10:15Z","timestamp":1656976215000},"page":"12-21","source":"Crossref","is-referenced-by-count":8,"title":["Endocarditis: Who Is Particularly at Risk and Why? Ten Years Analysis of Risk Factors for In-hospital Mortality in Infective Endocarditis"],"prefix":"10.1055","volume":"71","author":[{"given":"Roya","family":"Ostovar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erb","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Uwe","family":"Kuehnel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hartrumpf","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Albes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Brandenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"issue":"15","key":"ref1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCULATIONAHA.106.183095","article-title":"Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group","volume":"116","author":"W Wilson","year":"2007","journal-title":"Circulation"},{"issue":"23","key":"ref2","first-page":"e394","article-title":"Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic 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