{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:42:28Z","timestamp":1772811748322,"version":"3.50.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Primary ciliary dyskinesia is a rare inherited disease that results in a malfunction of mucociliary clearance and sinonasal complaints. Aplasia\/hypoplasia of the frontal and sphenoid sinuses has been described as more frequent in this population. However, to date, no studies have provided a detailed description of computed tomography findings in adult patients with a diagnosis of this condition.<\/jats:p><jats:p>\n          Objective\u2003To describe the computed tomography (CT) findings of adult patients with primary ciliary dyskinesia.<\/jats:p><jats:p>\n          Methods\u2003Retrospective observational study of adult patients with primary ciliary dyskinesia who underwent CT.<\/jats:p><jats:p>\n          Results\u2003Twenty-one adults were included in the study. Aplasia occurred in 38.1% of frontal sinuses and in 14.3% of sphenoid sinuses. Likewise, hypoplasia occurred in 47.6% of the frontal sinuses, in 54.8% of the sphenoid sinuses and in 40.5% of the maxillary sinuses. Furthermore, trabecular loss was identified in 61.9% ethmoidal sinuses. The mean Lund-Mackay score was 13.5. In addition, 9.5% of the patients had concha bullosa, 47.6% had marked bilateral inferior turbinate hypertrophy, 38.1% had marked middle turbinate hypertrophy, and 47.6% had marked septal deviation. Finally, we identified images suggestive of fungus ball, mucocele, osteoma, a possible antrochoanal polyp, and frontal bone erosions.<\/jats:p><jats:p>\n          Conclusion\u2003The present study provides a detailed description of CT findings in patients with primary ciliary dyskinesia. We also describe abnormalities that must be identified for safer surgical planning and that suggest a diagnosis of primary ciliary dyskinesia if found in patients with a consistent clinical picture.<\/jats:p>","DOI":"10.1055\/s-0042-1749392","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:25:08Z","timestamp":1659421508000},"page":"e130-e137","source":"Crossref","is-referenced-by-count":10,"title":["Computed Tomography Evaluation of the Paranasal Sinuses in Adults with Primary Ciliary Dyskinesia"],"prefix":"10.1055","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-6032","authenticated-orcid":false,"given":"Diogo Barreto","family":"Plantier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology and Ophthalmology, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4993","authenticated-orcid":false,"given":"Renata R. M.","family":"Pilan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology and Ophthalmology, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Athanazio","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Heart Institute, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-4655","authenticated-orcid":false,"given":"Mary Anne K.","family":"Olm","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-3825","authenticated-orcid":false,"given":"Eloisa M. S.","family":"Gebrim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-3387","authenticated-orcid":false,"given":"Richard Louis","family":"Voegels","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology and Ophthalmology, Faculdade de Medicina, Universidade de S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1183\/09031936.00176608","article-title":"Primary ciliary dyskinesia: a consensus statement on diagnostic and treatment approaches in children","volume":"34","author":"A Barbato","year":"2009","journal-title":"Eur Respir J"},{"issue":"09","key":"ref2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/hcu063","article-title":"Primary ciliary dyskinesia","volume":"107","author":"L J Lobo","year":"2014","journal-title":"QJM"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1183\/13993003.00736-2016","article-title":"Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis","volume":"48","author":"M Goutaki","year":"2016","journal-title":"Eur Respir J"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm8050619","article-title":"Critical Evaluation of Sinonasal Disease in 64 Adults with Primary Ciliary Dyskinesia","volume":"8","author":"E Bequignon","year":"2019","journal-title":"J Clin Med"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4193\/Rhino11.256","article-title":"Prevalence of chronic rhinosinusitis in Sao Paulo","volume":"50","author":"R RDM Pilan","year":"2012","journal-title":"Rhinology"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/thoraxjnl-2015-207891","article-title":"Clinical characteristics, functional respiratory decline and follow-up in adult patients with primary ciliary dyskinesia","volume":"72","author":"J Frija-Masson","year":"2017","journal-title":"Thorax"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. 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