{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:09:18Z","timestamp":1778098158029,"version":"3.51.4"},"reference-count":6,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Spontaneous downbeat nystagmus and ocular flutter are rare clinical signs. Such findings are commonly related to cerebellar pathology, predominantly ischemia. In a significant percentage of patients, the cause may not be found. If these signs are associated with ataxia, cognitive decline, and seizure, anti-glutamic acid decarboxylase-associated neurological syndrome must be suspected. Background history of tumor has to be enquired. Treatment with immune modulation helps in partial recovery of such cases.<\/jats:p>","DOI":"10.1055\/s-0042-1749404","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T22:42:42Z","timestamp":1660430562000},"page":"546-549","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spontaneous Downbeat Nystagmus in Anti-GAD-Antibody-Associated Paraneoplastic Syndrome"],"prefix":"10.25259","volume":"13","author":[{"given":"Sumanth","family":"Shivaram","sequence":"first","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok V. Reddy","family":"Tallapalli","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saraswati","family":"Nashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish B.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvarna","family":"Alladi","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"10.1055\/s-0042-1749404\/ref-1","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1093\/brain\/awn183","article-title":"Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association","volume":"131","author":"Saiz","year":"2008","journal-title":"Brain"},{"key":"10.1055\/s-0042-1749404\/ref-2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2015.10.024","article-title":"Spontaneous downbeat nystagmus as a clue for the diagnosis of ataxia associated with anti-GAD antibodies","volume":"359","author":"Vale","year":"2015","journal-title":"J Neurol Sci"},{"issue":"7","key":"10.1055\/s-0042-1749404\/ref-3","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1136\/jnnp.74.7.998","article-title":"Autoantibodies to glutamic acid decarboxylase in downbeat nystagmus","volume":"74","author":"Antonini","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"10.1055\/s-0042-1749404\/ref-4","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4065\/81.9.1207","article-title":"Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction","volume":"81","author":"Pittock","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"10.1055\/s-0042-1749404\/ref-5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/jnnp.2007.126284","article-title":"Downbeat nystagmus: aetiology and comorbidity in 117 patients","volume":"79","author":"Wagner","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1055\/s-0042-1749404\/ref-6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/0972-2327.150628","article-title":"Limbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms","volume":"18","author":"Incecik","year":"2015","journal-title":"Ann Indian Acad Neurol"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/spontaneous-downbeat-nystagmus-in-anti-gad-antibody-associated-paraneoplastic-syndrome\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/spontaneous-downbeat-nystagmus-in-anti-gad-antibody-associated-paraneoplastic-syndrome\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:39:24Z","timestamp":1691210364000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/spontaneous-downbeat-nystagmus-in-anti-gad-antibody-associated-paraneoplastic-syndrome\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,13]]},"references-count":6,"alternative-id":["10.1055\/s-0042-1749404"],"URL":"https:\/\/doi.org\/10.1055\/s-0042-1749404","relation":{},"ISSN":["0976-3155","0976-3147"],"issn-type":[{"value":"0976-3155","type":"electronic"},{"value":"0976-3147","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,13]]},"article-number":"546"}}