{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:26:51Z","timestamp":1793395611669,"version":"4.5.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"the Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","award":["50-53000-98-139"],"award-info":[{"award-number":["50-53000-98-139"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Assistance Publique des H\u00f4pitaux de Paris, Fondation Bettencourt-Schueller","award":["JPI-AMR\/ZonMW"],"award-info":[{"award-number":["JPI-AMR\/ZonMW"]}]},{"name":"Landsteiner Foundation","award":["LSBR # 1901"],"award-info":[{"award-number":["LSBR # 1901"]}]},{"name":"NACTAR","award":["16447"],"award-info":[{"award-number":["16447"]}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Activated platelets have been implicated in the proinflammatory and prothrombotic phenotype of coronavirus disease 2019 (COVID-19). While it is increasingly recognized that lipids have important structural and signaling roles in platelets, the lipidomic landscape of platelets during infection has remained unexplored.<\/jats:p><jats:p>\n          Objective\u2003To investigate the platelet lipidome of patients hospitalized for COVID-19.<\/jats:p><jats:p>\n          Methods\u2003We performed untargeted lipidomics in platelets of 25 patients hospitalized for COVID-19 and 23 noninfectious controls with similar age and sex characteristics, and with comparable comorbidities.<\/jats:p><jats:p>\n          Results\u2003Twenty-five percent of the 1,650 annotated lipids were significantly different between the groups. The significantly altered part of the platelet lipidome mostly comprised lipids that were less abundant in patients with COVID-19 (20.4% down, 4.6% up, 75% unchanged). Platelets from COVID-19 patients showed decreased levels of membrane plasmalogens, and a distinct decrease of long-chain, unsaturated triacylglycerols. Conversely, platelets from patients with COVID-19 displayed class-wide higher abundances of bis(monoacylglycero)phosphate and its biosynthetic precursor lysophosphatidylglycerol. Levels of these classes positively correlated with ex vivo platelet reactivity\u2014as measured by P-selectin expression after PAR1 activation\u2014irrespective of disease state.<\/jats:p><jats:p>\n          Conclusion\u2003Taken together, this investigation provides the first exploration of the profound impact of infection on the human platelet lipidome, and reveals associations between the lipid composition of platelets and their reactivity. These results warrant further lipidomic research in other infections and disease states involving platelet pathophysiology.<\/jats:p>","DOI":"10.1055\/s-0042-1749438","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T23:07:35Z","timestamp":1658185655000},"page":"1683-1692","source":"Crossref","is-referenced-by-count":28,"title":["The Platelet Lipidome Is Altered in Patients with COVID-19 and Correlates with Platelet Reactivity"],"prefix":"10.1055","volume":"122","author":[{"given":"Alex R.","family":"Schuurman","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-5760","authenticated-orcid":false,"given":"Valentine","family":"L\u00e9opold","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Department of Anesthesia and Intensive Care, H\u00f4pital Lariboisi\u00e8re, INSERM U942S MASCOT, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Pereverzeva","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osoul","family":"Chouchane","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom D. Y.","family":"Reijnders","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin de","family":"Brabander","sequence":"additional","affiliation":[{"name":"Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers - Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e A.","family":"Douma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Flevo Hospital, Almere, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel van","family":"Weeghel","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Core Facility Metabolomics, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wever","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Core Facility Metabolomics, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Department of Epidemiology & Data Science, Bioinformatics Laboratory, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauke V.","family":"Schomaker","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Core Facility Metabolomics, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric M.","family":"Vaz","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Core Facility Metabolomics, Amsterdam UMC, Amsterdam, The Netherlands"},{"name":"Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem Joost","family":"Wiersinga","sequence":"additional","affiliation":[{"name":"Center for Experimental and 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