{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:26:58Z","timestamp":1740148018748,"version":"3.37.3"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis","award":["2019-55-R"],"award-info":[{"award-number":["2019-55-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Comp Orthop Traumatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The aim of this study was to assess bone density, bone architecture and clinical function of canine nonunion distal appendicular long bone fractures with a defect treated with fixation, compression-resistant matrix and recombinant human bone morphogenetic protein-2 (rhBMP-2).<\/jats:p><jats:p>\n          Study Design\u2003Prospective cohort study with dogs at least 1-year post treatment. Computed tomography was performed and quantitative measurements from previous fracture sites were compared with measurements from contralateral limbs. Subjective evaluation included gait assessment and palpation.<\/jats:p><jats:p>\n          Results\u2003Six patients met the inclusion criteria. The rhBMP-2 treated bone exhibited higher density at the periphery and lower density in the centre, similar to the contralateral limb. All patients were weight bearing on the treated limb and all fractures were healed.<\/jats:p><jats:p>\n          Conclusion\u2003The rhBMP-2-treated bone underwent restoration of normal architecture and density. Acceptable limb function was present in all patients. The results of this study can serve as a basis for long-term response in treating nonunion fractures in veterinary patients.<\/jats:p>","DOI":"10.1055\/s-0042-1749451","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T23:24:46Z","timestamp":1656372286000},"page":"29-38","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Assessment of Bone Regeneration in Nonunion Fractures Treated with Compression-Resistant Matrix and Recombinant Human Bone Morphogenetic Protein-2 in Dogs"],"prefix":"10.1055","volume":"36","author":[{"given":"Andrea","family":"Castilla","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, Davis, University of California, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-6520","authenticated-orcid":false,"given":"Barbro","family":"Filliquist","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Spriet","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya C.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boaz","family":"Arzi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"},{"name":"Veterinary Institute for Regenerative Cures, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-5465","authenticated-orcid":false,"given":"Po-Yen","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Kapatkin","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref1","first-page":"163","volume-title":"Delayed union and nonunion. 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