{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:07:07Z","timestamp":1769839627599,"version":"3.49.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low-grade fibromyxoid sarcoma (LGFMS), also known as Evan's tumor, is a fibroblastic tumor with a deceptively bland morphology but a high metastasizing potential and late recurrence. It presents clinically as a slowly growing mass in the deep soft tissue of extremities and trunk. Morphologically, it shows a biphasic pattern with alternating fibrous and myxoid areas, whorling growth pattern, hypocellularity, and bland fibroblasts with curvilinear or arcuate vessels in between. Collagen rosettes with central hyalinization is a helpful feature but not specific. MUC-4 is the most sensitive immunostain in LGFMS. The majority of cases harbor a gene fusion in FUS-CREB3L2. Herein, we present a 23-year-old female patient with a slow growing painless mass in the left parotid gland, which was later diagnosed as LGFMS. Involvement of the head and neck region by LGFMS is uncommonly encountered. To date, only two cases within the parotid gland have been described.<\/jats:p>","DOI":"10.1055\/s-0042-1749611","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T23:01:37Z","timestamp":1655852497000},"source":"Crossref","is-referenced-by-count":1,"title":["Low-Grade Fibromyxoid Sarcoma Featuring an Unusual EWSR1-CREB3L2 Gene Fusion: Report of a Rare Case Arising in the Parotid Gland"],"prefix":"10.1055","author":[{"given":"Doaa M.","family":"Alayed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-9843","authenticated-orcid":false,"given":"Majed M.","family":"Pharaon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Ministry of National Guard, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"issue":"S 01","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12070-011-0305-8","article-title":"Head and neck leiomyosarcoma","volume":"65","author":"J Yadav","year":"2013","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/ajcp\/88.5.615","article-title":"Low-grade fibromyxoid sarcoma. A report of two metastasizing neoplasms having a deceptively benign appearance","volume":"88","author":"H L Evans","year":"1987","journal-title":"Am J Clin Pathol"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1097\/PAS.0b013e31822b3687","article-title":"Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up","volume":"35","author":"H L Evans","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12105-015-0647-8","article-title":"Low-grade fibromyxoid sarcoma of the head and neck: a clinicopathologic series and review of the literature","volume":"10","author":"M L Cowan","year":"2016","journal-title":"Head Neck Pathol"},{"key":"ref5","first-page":"907","article-title":"A giant sarcoma of the parotid gland: a case report and review of the literature","volume":"20","author":"B Botev","year":"2006","journal-title":"In Vivo"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s13256-015-0658-9","article-title":"Low grade fibromyxoid sarcoma of the parotid: case report","volume":"9","author":"E J Lee","year":"2015","journal-title":"J Med Case Reports"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1097\/00000478-199712000-00011","article-title":"Hyalinizing spindle cell tumor with giant rosettes: a distinctive tumor closely resembling low-grade fibromyxoid sarcoma","volume":"21","author":"K L Lane","year":"1997","journal-title":"Am J Surg Pathol"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/01.pas.0000146014.22624.8e","article-title":"Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population","volume":"29","author":"S D Billings","year":"2005","journal-title":"Am J Surg Pathol"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.joms.2009.04.136","article-title":"Low-grade fibromyxoid sarcoma: clinical study and case report","volume":"68","author":"Z Tang","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/01913129709023250","article-title":"Head and neck fibromyxoid sarcoma: clinicopathological correlation with emphasis on peculiar ultrastructural features related to collagen processing","volume":"21","author":"J C Papadimitriou","year":"1997","journal-title":"Ultrastruct Pathol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/00313020802579276","article-title":"Low grade fibromyxoid sarcoma: problems in the diagnosis and management of a malignant tumour with bland histological appearance","volume":"41","author":"X Wu","year":"2009","journal-title":"Pathology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2152\/jmi.59.266","article-title":"Recurring facial low-grade fibromyxoid sarcoma in an elderly patient: a case report","volume":"59","author":"Y Abe","year":"2012","journal-title":"J Med Invest"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.joms.2012.12.017","article-title":"Low-grade fibromyxoid sarcoma with cystic appearance and osseous metaplasia in the cheek: a case report and review of the literature","volume":"71","author":"K F He","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/0973-029X.185914","article-title":"Low-grade fibromyxoid sarcoma involving the mandible: a diagnostic dilemma","volume":"20","author":"K Chaudhuri","year":"2016","journal-title":"J Oral Maxillofac Pathol"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4103\/ijo.IJO_633_18","article-title":"Primary orbital low-grade fibromyxoid sarcoma - a case report","volume":"67","author":"R Rao","year":"2019","journal-title":"Indian J Ophthalmol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.anndiagpath.2011.02.005","article-title":"Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases","volume":"15","author":"B Rekhi","year":"2011","journal-title":"Ann Diagn Pathol"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12105-010-0204-4","article-title":"Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre","volume":"4","author":"S Viswanathan","year":"2010","journal-title":"Head Neck Pathol"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1159\/000325411","article-title":"Low grade fibromyxoid sarcoma: report of a case with epithelioid cell morphology, masquerading as a papillary thyroid carcinoma","volume":"53","author":"S H Merchant","year":"2009","journal-title":"Acta Cytol"},{"issue":"09","key":"ref21","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/PAS.0b013e3180321959","article-title":"Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group","volume":"31","author":"L Guillou","year":"2007","journal-title":"Am J Surg Pathol"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/gcc.22215","article-title":"A genetic dichotomy between pure sclerosing epithelioid fibrosarcoma (SEF) and hybrid SEF\/low-grade fibromyxoid sarcoma: a pathologic and molecular study of 18 cases","volume":"54","author":"C Prieto-Granada","year":"2015","journal-title":"Genes Chromosomes Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.anndiagpath.2017.04.001","article-title":"Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features","volume":"28","author":"M Mohamed","year":"2017","journal-title":"Ann Diagn Pathol"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/labinvest.3700230","article-title":"Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS\/CREB3L1 fusion gene","volume":"85","author":"F Mertens","year":"2005","journal-title":"Lab Invest"}],"container-title":["Avicenna Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1749611.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T23:01:52Z","timestamp":1655852512000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1749611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":22,"URL":"https:\/\/doi.org\/10.1055\/s-0042-1749611","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2231-0770","2249-4464"],"issn-type":[{"value":"2231-0770","type":"print"},{"value":"2249-4464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}