{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:19:30Z","timestamp":1773371970958,"version":"3.50.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Giant cell tumor (GCT) is a primary bone tumor of long bones, which can rarely involve the vertebrae. Contiguous vertebral involvement by GCT is a rare presentation and poses a diagnostic dilemma on imaging. We report a case of GCT involving three contiguous lumbar vertebrae causing vertebral collapse along with a large soft tissue component. Considering the site and clinical presentation, possibilities of a round cell tumor with large extraosseous soft tissue component and malignant neurogenic tumor were suggested on initial radiological examination but histopathology confirmed the diagnosis of GCT. It is important to diagnose this entity correctly because of totally different lines of management. In our case, initial surgical management was excluded in view of high surgical morbidity and, thereby, adjuvant therapy with denosumab was planned.<\/jats:p>","DOI":"10.1055\/s-0042-1750069","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T23:10:01Z","timestamp":1658877001000},"page":"156-158","source":"Crossref","is-referenced-by-count":1,"title":["Contiguous Lumbar Vertebral Involvement with Vertebral Collapse in Giant Cell Tumor: A Usual Tumor with an Unusual Presentation"],"prefix":"10.25259","volume":"15","author":[{"given":"Ankita","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinderpal Singh","family":"Dhanota","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchita","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani Kumar","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neena","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/01.coc.0000195089.11620.b7","article-title":"Giant cell tumor of bone","volume":"29","author":"W M Mendenhall","year":"2006","journal-title":"Am J Clin Oncol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0974-8237.116542","article-title":"Giant cell tumor of dorsal vertebral body","volume":"3","author":"R Redhu","year":"2012","journal-title":"J Craniovertebr Junction Spine"},{"key":"ref3","first-page":"68","article-title":"Giant cell tumor of dorsal vertebrae-a rare case report with review of literature","volume":"2","author":"K Akhtar","year":"2017","journal-title":"Adv Cytol Pathol."},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/0019-5413.32047","article-title":"Giant cell tumor of the spine: a review of 9 surgical interventions in 6 cases","volume":"41","author":"S Y Bhojraj","year":"2007","journal-title":"Indian J Orthop"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12891-020-3129-4","article-title":"Recurrent giant cell tumour of the thoracic spine managed by total en bloc spondylectomy and denosumab therapy: a case report","volume":"21","author":"P G Duan","year":"2020","journal-title":"BMC Musculoskelet Disord"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1148\/rg.292085137","article-title":"MR imaging assessment of the spine: infection or an imitation?","volume":"29","author":"S H Hong","year":"2009","journal-title":"Radiographics"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.diii.2012.04.003","article-title":"Infections of the spinal column\u2013spondylodiscitis","volume":"93","author":"N Sans","year":"2012","journal-title":"Diagn Interv Imaging"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/foc.2003.15.2.13","article-title":"Giant cell tumor of the sacrum","volume":"15","author":"R L Randall","year":"2003","journal-title":"Neurosurg Focus"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1470-2045(10)70010-3","article-title":"Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study","volume":"11","author":"D Thomas","year":"2010","journal-title":"Lancet Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/1471-2407-10-462","article-title":"Bisphosphonate treatment of aggressive primary, recurrent and metastatic giant cell tumour of bone","volume":"10","author":"M Balke","year":"2010","journal-title":"BMC Cancer"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1750069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:20:38Z","timestamp":1703406038000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/contiguous-lumbar-vertebral-involvement-with-vertebral-collapse-in-giant-cell-tumor-a-usual-tumor-with-an-unusual-presentation\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,26]]},"references-count":10,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,4,14]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1750069","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,26]]}}}