{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:52:08Z","timestamp":1778802728033,"version":"3.51.4"},"reference-count":13,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute myeloid leukemia (AML) are a diverse group of hematological malignancies, each with a distinct clinical, morphological, immunophenotypic, and molecular profile. The World Health Organization (WHO) classifies AML into various subtypes based on recurrent genetic abnormalities, each of which has clinico-pathological and prognostic significance. Inversion(16)(p13q22) or t(16;16)(p13q22) is a balanced structural chromosomal abnormality associated with complete remission and a favorable response to treatment. Trisomy 9 is a numerical chromosomal abnormality with an intermediate risk and is often seen in association with other cytogenetic abnormalities. We describe a case of a 36-year-old female patient who was diagnosed as AML-M4 on peripheral smear and bone marrow evaluation. Cytogenetic studies revealed concurrent presence of inv(16) and trisomy 9. To the best of our knowledge, this is the first case in published literature with simultaneous presence of inv(16)(p13q22) and trisomy 9 in de novo AML.<\/jats:p>","DOI":"10.1055\/s-0042-1750070","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T23:10:01Z","timestamp":1658877001000},"page":"142-145","source":"Crossref","is-referenced-by-count":2,"title":["Acute Myeloid Leukemia with Concurrent Inversion 16 and Trisomy 9: A Case Report"],"prefix":"10.25259","volume":"15","author":[{"given":"Ambreen","family":"Aman","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavitha B.","family":"Lingappa","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika G.","family":"Sujatha","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhan Ali","family":"Rajasab","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddapa","family":"Shantala","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.critrevonc.2010.11.006","article-title":"Cytogenetic abnormalities in adult non-promyelocytic acute myeloid leukemia: a concise review","volume":"80","author":"F Marchesi","year":"2011","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref2","first-page":"439","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"S H Swerdlow","year":"2017"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ajh.20716","article-title":"Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases","volume":"81","author":"C M Lu","year":"2006","journal-title":"Am J 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Kim","year":"2006","journal-title":"Leukemia"},{"issue":"06","key":"ref10","first-page":"6725","article-title":"An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): a case report","volume":"18","author":"M Gao","year":"2019","journal-title":"Oncol Lett"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2002-11-3527","article-title":"Prognosis of inv(16)\/t(16;16) acute myeloid leukemia (AML): a survey of 110 cases from the French AML Intergroup","volume":"102","author":"J Delaunay","year":"2003","journal-title":"Blood"},{"issue":"28","key":"ref12","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1200\/JCO.2008.21.0674","article-title":"Acute myeloid leukemia with translocation (8;21) or inversion (16) in elderly patients treated with conventional chemotherapy: a collaborative study of the French CBF-AML intergroup","volume":"27","author":"T Pr\u00e9bet","year":"2009","journal-title":"J Clin Oncol"},{"key":"ref13","first-page":"748a","article-title":"Prognostic significance of WBC, age, and cytogenetics in patients with core binding factor AML: a comparative study from the French AML intergroup","volume":"100","author":"J Delaunay","year":"2002","journal-title":"Blood"}],"container-title":["Journal of Laboratory 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