{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:55:32Z","timestamp":1740156932449,"version":"3.37.3"},"reference-count":15,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Laboratory investigations for any suspected case of solitary plasmacytoma of bone include routine biochemical and hematological investigations along with \u03b22-microglobulin, electrophoresis of serum protein and\/or 24-hour urine protein, serum protein immunofixation (IFE), and nephelometric quantification of total immunoglobulin isotype and serum free light chain levels. Bone marrow aspirate and trephine biopsy are mandatory to confirm the absence of clonal plasma cells (for solitary plasmacytoma) or the presence of less than 10% clonal cells (solitary plasmacytoma with minimal bone marrow involvement). Imaging studies such as X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission tomography\/CT should be used to complement laboratory tests in diagnosis, staging, and defining the local extent of the plasmacytoma. However, guidelines regarding choice of technique for the detection of M band when monitoring a follow-up case of operated plasmacytoma are still not clear. Through this case study, we try to highlight the role of IFE in a follow-up case of operated solitary plasmacytoma of the bone.<\/jats:p>","DOI":"10.1055\/s-0042-1750080","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T23:10:01Z","timestamp":1658877001000},"page":"162-165","source":"Crossref","is-referenced-by-count":0,"title":["Posttreatment Persistence of Monoclonal Protein on Immunofixation Electrophoresis but Absence on Serum Protein Electrophoresis in a Case of Solitary Bone Plasmacytoma"],"prefix":"10.25259","volume":"15","author":[{"given":"Visesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priti","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, All India Institute of Medical Sciences , Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-6972","authenticated-orcid":false,"given":"Mala","family":"Mahto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"895765","DOI":"10.1100\/2012\/895765","article-title":"A review for solitary plasmacytoma of bone and extramedullary plasmacytoma","volume":"2012","author":"S Kilciksiz","year":"2012","journal-title":"ScientificWorldJournal"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","article-title":"A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival","volume":"36","author":"B GM Durie","year":"1975","journal-title":"Cancer"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.thj.6200312","article-title":"Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation","volume":"4","author":"B GM Durie","year":"2003","journal-title":"Hematol J"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0360-3016(98)00186-2","article-title":"Solitary bone plasmacytoma: outcome and prognostic factors following radiotherapy","volume":"41","author":"R H Liebross","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"01","key":"ref5","first-page":"47","article-title":"Clinical outcome of extramedullary plasmacytoma","volume":"85","author":"P Galieni","year":"2000","journal-title":"Haematologica"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2141.2004.04834.x","article-title":"Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma","volume":"124","author":"R Soutar","year":"2004","journal-title":"Br J Haematol"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1182\/blood.V96.6.2037","article-title":"Solitary plasmacytoma of bone and asymptomatic multiple myeloma","volume":"96","author":"M A Dimopoulos","year":"2000","journal-title":"Blood"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group","volume":"121","author":"International Myeloma Working Group","year":"2003","journal-title":"Br J Haematol"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"S V Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-017-0549-1","article-title":"Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel","volume":"11","author":"J Caers","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.7861\/clinmed.2019-0488","article-title":"Clinical presentation and outcomes of solitary plasmacytoma in a tertiary hospital in the UK","volume":"20","author":"C Agbuduwe","year":"2020","journal-title":"Clin Med (Lond)"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/cncr.10366","article-title":"Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone","volume":"94","author":"R B Wilder","year":"2002","journal-title":"Cancer"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1182\/blood-2006-04-015784","article-title":"Immunoglobulin free light chains and solitary plasmacytoma of bone","volume":"108","author":"D Dingli","year":"2006","journal-title":"Blood"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3857\/roj.2019.00570","article-title":"The predictive value of serum myeloma protein in solitary plasmacytoma","volume":"38","author":"W I Chang","year":"2020","journal-title":"Radiat Oncol J"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/clinchem\/hvab235","article-title":"No monoclonal protein in a patient with CRAB features","volume":"67","author":"J Jean","year":"2021","journal-title":"Clin Chem"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1750080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:20:40Z","timestamp":1703406040000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/posttreatment-persistence-of-monoclonal-protein-on-immunofixation-electrophoresis-but-absence-on-serum-protein-electrophoresis-in-a-case-of-solitary-bone-plasmacytoma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,26]]},"references-count":15,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,4,14]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1750080","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"type":"print","value":"0974-2727"},{"type":"electronic","value":"0974-7826"}],"subject":[],"published":{"date-parts":[[2022,7,26]]}}}