{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:40:58Z","timestamp":1758192058450,"version":"3.44.0"},"reference-count":11,"publisher":"Necmettin Erbakan University Press","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meningococcal disease is associated with high mortality despite aggressive antibiotic therapy and intensive care support. Patients may develop refractory hypotension and acute respiratory distress syndrome in which extracorporeal membrane oxygenation (ECMO) could serve as a life-saving rescue therapy. However, there is limited data regarding the outcomes of ECMO support in the setting of meningococcal disease. This retrospective analysis of prospectively collected data from Extracorporeal Life Support Organization registry (1989\u20132019) enrolled children (29 days\u201318 years old) with Neisseria meningitidis infection receiving ECMO for any support type and mode. A total of 122 patients underwent a single course of ECMO support, equating to 122 ECMO runs. The overall survival-to-discharge rate was 46.7%. Patients receiving pulmonary venovenous (VV) ECMO had the highest survival-to-discharge of 85.7%, while those receiving venoarterial (VA) ECMO for pulmonary indications had a survival of 32.4%. Patients receiving VA ECMO support for cardiac indications had a survival-to-discharge rate of 60.9%. Those needing extracorporeal cardiopulmonary resuscitation (ECPR) had a poor survival (14.3%). Hemorrhagic complications were common, occurring in 43.4% of patients, but not found to be associated with mortality (complication was present in 47.7% of deceased and 38.6% of survivors, p\u2009=\u20090.31). Multivariable logistic regression analysis revealed that neurologic complications were associated with increased odds of mortality (odds ratio: 44.11; 95% confidence interval: 4.95\u2013393.08). ECMO can be utilized as rescue therapy in children with refractory cardiopulmonary failure in setting of meningococcemia. Patients who require pulmonary VV or cardiac ECMO have the best ECMO outcomes. However, the use of ECMO in those suffering cardiac arrest (ECPR) should be undertaken with caution.<\/jats:p>","DOI":"10.1055\/s-0042-1750302","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T18:56:08Z","timestamp":1659034568000},"page":"337-343","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes of Extracorporeal Life Support in Children with Meningococcal Septicemia: A Retrospective Cohort Study"],"prefix":"10.53391","volume":"12","author":[{"given":"Brandon Michael","family":"Henry","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Benscoter","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Perry","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena Santos","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Statistics, Federal University of Parana, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Misfeldt","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1056\/NEJM199301073280104","article-title":"Acute bacterial meningitis in adults. A review of 493 episodes","volume":"328","author":"M L Durand","year":"1993","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.2147\/IDR.S240162","article-title":"Management of acute bacterial meningitis in children","volume":"13","author":"Z Alamarat","year":"2020","journal-title":"Infect Drug Resist"},{"issue":"21","key":"ref3","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","article-title":"Bacterial meningitis in the United States, 1998-2007","volume":"364","author":"M C Thigpen","year":"2011","journal-title":"N Engl J Med"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e979","DOI":"10.1542\/peds.2006-0281","article-title":"Multicenter surveillance of invasive meningococcal infections in children","volume":"118","author":"S L Kaplan","year":"2006","journal-title":"Pediatrics"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF01712247","article-title":"The outcome of children admitted to intensive care with meningococcal septicaemia","volume":"22","author":"Q Mok","year":"1996","journal-title":"Intensive Care Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1651-2227.2004.tb00851.x","article-title":"Extracorporeal life support for children with meningococcal septicaemia","volume":"93","author":"D K Luyt","year":"2004","journal-title":"Acta Paediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(96)12106-1","article-title":"Extracorporeal support for intractable cardiorespiratory failure due to meningococcal disease","volume":"349","author":"A P Goldman","year":"1997","journal-title":"Lancet"},{"volume-title":"ECMO Registry of the Extracorporeal Life Support Organization (ELSO)","year":"2019","key":"ref8"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"e0215730","DOI":"10.1371\/journal.pone.0215730","article-title":"Use of extracorporeal membrane oxygenation and associated outcomes in children hospitalized for sepsis in the United States: a large population-based study","volume":"14","author":"K Robb","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4103\/0972-5229.167038","article-title":"Venoarterial extracorporeal membrane oxygenation support for neonatal and pediatric refractory septic shock","volume":"19","author":"J Rambaud","year":"2015","journal-title":"Indian J Crit Care Med"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpedsurg.2011.10.018","article-title":"Improved survival in venovenous vs venoarterial extracorporeal membrane oxygenation for pediatric noncardiac sepsis patients: a study of the Extracorporeal Life Support Organization registry","volume":"47","author":"S C Skinner","year":"2012","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Pediatric Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1750302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:50:20Z","timestamp":1758138620000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1750302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":11,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2023,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1750302","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2146-4618","2146-4626"],"issn-type":[{"type":"print","value":"2146-4618"},{"type":"electronic","value":"2146-4626"}],"subject":[],"published":{"date-parts":[[2022,7,28]]}}}