{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:12:26Z","timestamp":1793189546795,"version":"4.5.0"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Transcatheter aortic valve replacement (TAVR) has become an established alternative to surgical aortic valve replacement (AVR) for higher risk patients. Periprocedural TAVR complications decreased with a growing expertise of implanters. Yet, TAVR can be accompanied by life-threatening adverse events such as intraprocedural cardiopulmonary resuscitation (CPR). This study retrospectively analyzed predictors and outcomes in a cohort of patients from a high-volume center undergoing periprocedural CPR during TAVR.<\/jats:p><jats:p>\n          Methods\u2003A total of 729 patients undergoing TAVR, including 59 with intraprocedural CPR, were analyzed with respect to peri- and postprocedural outcomes.<\/jats:p><jats:p>\n          Results\u2003Patients undergoing CPR showed a significantly lower left ventricular ejection fraction (LVEF) and lower baseline transvalvular mean and peak pressure gradients. The systolic blood pressure measured directly preoperatively was significantly lower in the CPR cohort. CPR patients were in a higher need for intraprocedural defibrillation, heart\u2013lung circulatory support, and conversion to open heart surgery. Further, they showed a higher incidence of atrioventricular block grade III , valve malpositioning, and pericardial tamponade. The in-hospital mortality was significantly higher after intraprocedural CPR, accompanied by a higher incidence of disabling stroke, new pacemaker implantation, more red blood cell transfusion, and longer stay in intensive care unit.<\/jats:p><jats:p>\n          Conclusion\u2003Impaired preoperative LVEF and instable hemodynamics before valve deployment are independent risk factors for CPR and are associated with compromised outcomes. Heart rhythm disturbances, malpositioning of the prosthesis, and pericardial tamponade are main causes of the high mortality of 17% reported in the CPR group. Nevertheless, mechanical circulatory support and conversion to open heart surgery reduce mortality rates of CPR patients.<\/jats:p>","DOI":"10.1055\/s-0042-1750304","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T22:50:26Z","timestamp":1658271026000},"page":"101-106","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes and Characteristics of Patients with Intraprocedural Cardiopulmonary Resuscitation during TAVR"],"prefix":"10.1055","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-6766","authenticated-orcid":false,"given":"Stephen","family":"Gerfer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar W.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Gablac","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borko","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-8626","authenticated-orcid":false,"given":"Ilija","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Mader","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-7785","authenticated-orcid":false,"given":"Kaveh","family":"Eghbalzadeh","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten C. W.","family":"Wahlers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Cologne, Koln, Nordrhein-Westfalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/S0140-6736(15)60308-7","article-title":"5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial","volume":"385","author":"M J Mack","year":"2015","journal-title":"Lancet"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"M J Reardon","year":"2017","journal-title":"N Engl J Med"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1053\/j.jvca.2019.04.016","article-title":"TAVR procedural volumes and patient outcomes: analysis of recent data","volume":"34","author":"D Cormican","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"18","key":"ref4","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"J J Popma","year":"2019","journal-title":"N Engl J Med"},{"issue":"18","key":"ref5","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"M J Mack","year":"2019","journal-title":"N Engl J Med"},{"issue":"18","key":"ref6","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.jcin.2019.04.026","article-title":"Incidence and outcomes of surgical bailout during TAVR: insights from the STS\/ACC TVT registry","volume":"12","author":"A M Pineda","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7598581","DOI":"10.1155\/2019\/7598581","article-title":"Outcomes of emergency transcatheter aortic valve replacement","volume":"2019","author":"H Huang","year":"2019","journal-title":"J Interv Cardiol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00392-020-01752-4","article-title":"Risk of mortality following transcatheter aortic valve replacement for low-flow low-gradient aortic stenosis","volume":"110","author":"N Wilde","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.carrev.2017.09.011","article-title":"Intraprocedural invasive hemodynamic parameters as predictors of short- and long-term outcomes in patients undergoing transcatheter aortic valve replacement","volume":"19","author":"S Kiramijyan","year":"2018","journal-title":"Cardiovasc Revasc Med"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cjca.2021.05.002","article-title":"Catastrophic cardiac events during transcatheter aortic valve replacement","volume":"37","author":"Y Liang","year":"2021","journal-title":"Can J Cardiol"},{"issue":"09","key":"ref11","doi-asserted-by":"crossref","first-page":"e016700","DOI":"10.1161\/JAHA.120.016700","article-title":"Pacemaker implantation after transcatheter aortic valve replacement: a necessary evil perhaps but are we making progress?","volume":"9","author":"H D Huang","year":"2020","journal-title":"J Am Heart Assoc"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1750304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T01:26:21Z","timestamp":1678411581000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1750304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":11,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,3,9]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1750304","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,19]]}}}