{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:40:41Z","timestamp":1770752441673,"version":"3.50.0"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nucl Med"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Huge variation in the prevalence of post cholecystectomy syndrome (PCS) is because PCS can include a wide variety of disorders that can be both related and unrelated to cholecystectomy. Hepatobiliary scintigraphy (HBS) is a noninvasive nuclear medicine scan that can evaluate a delay in the transit of bile from the hepatic hilum to the duodenum using a radiotracer 99mTc-Mebrofenin that can be associated with a functional ampullary obstruction. The aim of this study was to assess the role of 99mTc-Mebrofenin HBS in the detection of the cause of PCS among the patients undergoing cholecystectomy.<\/jats:p><jats:p>\n          Methods\u2003Twenty-one patients who presented with PCS from September 2018 to February 2020 were included in the study. These patients were characterized based on history, examination, liver function test, and abdominal ultrasound. Sphincter of Oddi dysfunction (SOD) was diagnosed using the Rome 3 criteria and the Milwaukee classification. Magnetic resonance cholangiopancreatography (MRCP) and upper gastrointestinal endoscopy and biopsy were done when indicated, to establish the diagnosis. These patients were further subjected to 99mTc-Mebrofenin HBS, and the findings were analyzed.<\/jats:p><jats:p>\n          Results\u2003The most common symptom in PCS was biliary pain occurring in 85.7% of the patients. The average time of presentation since surgery was 1.9 years. The most common cause of PCS was SOD, occurring in 52.3% of the patients, followed by benign biliary stricture occurring in 23.8% of the patients. The mean bile duct (common bile duct) visualization time in patients with PCS was 25.2\u2009minutes, the mean duodenal visualization time was 38.2\u2009minutes, and the mean jejunal visualization time was 60.5\u2009minutes. The mean bile duct to duodenum transit time was 12.7\u2009minutes, while the mean bile duct to jejunum transit time was 30.1\u2009minutes. HBS showed consistent findings with the final diagnosis made by other diagnostic modalities (clinical criteria\/MRCP\/intraoperative findings) in 80.9% of the patients.<\/jats:p><jats:p>\n          Conclusion\u200399mTc-Mebrofenin HBS has a significant role in the evaluation of PCS.<\/jats:p>","DOI":"10.1055\/s-0042-1751038","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T01:15:55Z","timestamp":1660698955000},"page":"231-235","source":"Crossref","is-referenced-by-count":4,"title":["Role of 99mTc-Mebrofenin Hepatobiliary Scintigraphy in the Diagnosis of Post Cholecystectomy Syndrome"],"prefix":"10.1055","volume":"21","author":[{"given":"S. Durga","family":"Sowmya","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manishi L.","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udit","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Radiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaydeep","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanuj","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaine John","family":"Chennatt","sequence":"additional","affiliation":[{"name":"Department of Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1080\/00365520510023675","article-title":"From acute to chronic pain after laparoscopic cholecystectomy: a prospective follow-up analysis","volume":"40","author":"T Bisgaard","year":"2005","journal-title":"Scand J Gastroenterol"},{"issue":"988","key":"ref2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1259\/bjr\/99865290","article-title":"Post-cholecystectomy syndrome: spectrum of biliary findings at magnetic resonance cholangiopancreatography","volume":"83","author":"R Girometti","year":"2010","journal-title":"Br J Radiol"},{"issue":"24","key":"ref3","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.3748\/wjg.v12.i24.3793","article-title":"Sphincter of Oddi dysfunction: managing the patient with chronic biliary pain","volume":"12","author":"L Bistritz","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-2002-23629","article-title":"Sphincter of Oddi dysfunction: pancreaticobiliary sphincterotomy with pancreatic stent placement has a lower rate of pancreatitis than biliary sphincterotomy alone","volume":"34","author":"E L Fogel","year":"2002","journal-title":"Endoscopy"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2967\/jnumed.113.131490","article-title":"Hepatobiliary scintigraphy in 2014","volume":"55","author":"H A Ziessman","year":"2014","journal-title":"J Nucl Med"},{"key":"ref6","first-page":"65","volume-title":"Imaging agents","author":"G T Krishnamurthy","year":"2009"},{"issue":"01","key":"ref7","first-page":"185","article-title":"Prevalence of adverse reactions in nuclear medicine","volume":"37","author":"E B Silberstein","year":"1996","journal-title":"J Nucl Med"},{"key":"ref8","first-page":"1294","volume-title":"Biliary dyskinesia and Sphincter of Oddi dysfunction","author":"A K Morgan","year":"2019"},{"issue":"09","key":"ref9","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/BF02088136","article-title":"Hepatoduodenal bile transit in cholecystectomized subjects. Relationship with sphincter of Oddi function and diagnostic value","volume":"39","author":"E Corazziari","year":"1994","journal-title":"Dig Dis Sci"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0001-2998(96)80013-4","article-title":"Cholecystokinin and morphine pharmacological intervention during 99mTc-HIDA cholescintigraphy: a rational approach","volume":"26","author":"S Krishnamurthy","year":"1996","journal-title":"Semin Nucl Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnut.2017.00001","article-title":"Sphincter of Oddi function and risk factors for dysfunction","volume":"4","author":"E Afghani","year":"2017","journal-title":"Front Nutr"},{"issue":"06","key":"ref12","first-page":"1216","article-title":"A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: the scintigraphic score","volume":"33","author":"S Sostre","year":"1992","journal-title":"J Nucl Med"}],"container-title":["World Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1751038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:22:19Z","timestamp":1662078139000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1751038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":12,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,9,1]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1751038","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1450-1147","1607-3312"],"issn-type":[{"value":"1450-1147","type":"print"},{"value":"1607-3312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]}}}