{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:10Z","timestamp":1787004910969,"version":"build-2736575974"},"reference-count":85,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Despite the high prevalence of non-alcoholic fatty liver disease (NAFLD) in primary care (25%), only a small minority (&lt; 5%) of NAFLD patients will develop advanced liver fibrosis. The challenge is to identify these patients, who are at the greatest risk of developing complications and need to be referred to liver clinics for specialized management. The focus should change from patients with abnormal liver tests toward patients \u201cat risk of NAFLD,\u201d namely those with metabolic risk factors, such as obesity and type 2 diabetes. Non-invasive tests are well validated for diagnosing advanced fibrosis. Algorithms using FIB-4 as the first-line test, followed, if positive (\u2265 1.3), by transient elastography or a patented blood test are the best strategy to define pathways for \u201cat-risk\u201d NAFLD patients from primary care to liver clinics. Involving general practitioners actively and raising their awareness regarding NAFLD and non-invasive tests are critical to establish such pathways.<\/jats:p>","DOI":"10.1055\/s-0042-1751081","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T19:27:56Z","timestamp":1657826876000},"page":"313-326","source":"Crossref","is-referenced-by-count":11,"title":["Noninvasive Algorithms for the Case Finding of \u201cAt-Risk\u201d Patients with NAFLD"],"prefix":"10.1055","volume":"42","author":[{"given":"Laurent","family":"Castera","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, UMR1149 (CRI), INSERM, Paris, France"},{"name":"Service d'H\u00e9patologie, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Beaujon, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Boursier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato-Gastroent\u00e9rologie et 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