{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:08:30Z","timestamp":1790964510466,"version":"4.1.0"},"reference-count":35,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"11","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Nipple-sparing mastectomy (NSM) has been traditionally used in selected cases with tumor-to-nipple distance\u2009&gt;\u20092\u2009cm and negative frozen section of the base of the nipple. Recommending NSM in unselected populations remains controversial. The present study evaluated the oncological outcomes of patients submitted to NSM in an unselected population seen at a single center.<\/jats:p><jats:p>\n          Methods\u2003This retrospective cohort study included unselected patients with invasive carcinoma or ductal carcinoma in situ (DCIS) who underwent NSM in 2010 to 2020. The endpoints were locoregional recurrence, disease-free survival (DFS), and overall survival (OS), irrespective of tumor size or tumor-to-nipple distance.<\/jats:p><jats:p>\n          Results\u2003Seventy-six patients (mean age 46.1 years) (58 invasive carcinomas\/18 DCIS) were included. The most invasive carcinomas were hormone-positive (60%) (HER2 overexpression: 24%; triple-negative: 16%), while 39% of DCIS were high-grade. Invasive carcinomas were T2 in 66% of cases, with axillary metastases in 38%. Surgical margins were all negative. All patients with invasive carcinoma received systemic treatment and 38% underwent radiotherapy. After a mean of 34.8 months, 3 patients with invasive carcinoma (5.1%) and 1 with DCIS (5.5%) had local recurrence. Two patients had distant metastasis and died during follow-up. The 5-year OS and DFS rates for invasive carcinoma were 98% and 83%, respectively.<\/jats:p><jats:p>\n          Conclusion\u2003In unselected cases, the 5-year oncological outcomes following NSM were found to be acceptable and comparable to previous reports. Further studies are required.<\/jats:p>","DOI":"10.1055\/s-0042-1751286","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T23:42:17Z","timestamp":1672357337000},"page":"1052-1058","source":"Crossref","is-referenced-by-count":5,"title":["Oncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-2890","authenticated-orcid":false,"given":"Francisco Pimentel","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-5682","authenticated-orcid":false,"given":"Mirella Macedo Parente","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Grupo de Educa\u00e7\u00e3o e Estudos Oncol\u00f3gicos, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-225X","authenticated-orcid":false,"given":"Igor Moreira","family":"Veras","sequence":"additional","affiliation":[{"name":"Centro Regional Integrado de Oncologia, Fortaleza, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-8598","authenticated-orcid":false,"given":"Ruffo","family":"Freitas-Junior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for 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