{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:38:12Z","timestamp":1779338292535,"version":"3.51.4"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063036"],"award-info":[{"award-number":["U10 HD063036"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063072"],"award-info":[{"award-number":["U10 HD063072"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063047"],"award-info":[{"award-number":["U10 HD063047"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063037"],"award-info":[{"award-number":["U10 HD063037"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063041"],"award-info":[{"award-number":["U10 HD063041"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063020"],"award-info":[{"award-number":["U10 HD063020"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063046"],"award-info":[{"award-number":["U10 HD063046"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063048"],"award-info":[{"award-number":["U10 HD063048"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U10 HD063053"],"award-info":[{"award-number":["U10 HD063053"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["UL1TR001108"],"award-info":[{"award-number":["UL1TR001108"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["UL1TR000153"],"award-info":[{"award-number":["UL1TR000153"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n            Objective\u2003The objective of this study was to derive profiles of alcohol, tobacco, and recreational drug use during pregnancy for first-time mothers with latent class growth analysis (LCGA) and determine the association of these classes with the risk of adverse pregnancy outcomes (APO).<\/jats:p><jats:p>\n            Study Design\u2003A secondary analysis of a prospective cohort of Nulliparous Outcomes in Pregnancy: Monitoring Mothers-to-Be was conducted in eight medical centers across the United States from September 30, 2010, to September 23, 2013. Self-reported use of any alcohol, tobacco, or recreational drugs in the 1 month prior to the visit was assessed at up to four visits throughout pregnancy, and APOs included a composite of preterm birth, hypertensive disorder of pregnancy (HDP), small for gestational age (SGA) infant, or stillbirth, and each adverse outcome separately.<\/jats:p><jats:p>\n            Results\u2003Four latent classes were identified from the LCGA for 10,031 nulliparous pregnant women that were on average 26.9 years old (standard deviation [SD]\u2009=\u20095.7) and mostly non-Hispanic White (59.7%). Classes included consistent tobacco users (N\u2009=\u2009517, 5.2%), nonusers (N\u2009=\u20098,945, 89.2%), alcohol users (N\u2009=\u2009500, 5.0%), and a combination of alcohol\/tobacco\/drug users (N\u2009=\u200969, 0.7%). Logistic regression demonstrated that the class of tobacco users was more likely to have an APO (odds ratio [OR]\u2009=\u20091.48, 95% confidence interval [CI]\u2009=\u20091.22\u20131.81), preterm birth (OR\u2009=\u20091.53, 95% CI\u2009=\u20091.15\u20132.02), and SGA (OR\u2009=\u20091.79, 95% CI\u2009=\u20091.36\u20132.35) relative to the class of nonusers. The class of alcohol users was more likely to have HDP (OR\u2009=\u20091.37, 95% CI\u2009=\u20091.11\u20131.70) and less likely to have preterm birth (OR\u2009=\u20090.59, 95% CI\u2009=\u20090.38\u20130.90) and SGA (OR\u2009=\u20090.61, 95% CI\u2009=\u20090.40\u20130.93) compared to nonusers.<\/jats:p><jats:p>\n            Conclusion\u2003Trajectories of substance use are associated with APOs; thus, interventions to mitigate the use when encountered early in pregnancy are warranted.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1753502","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:39:21Z","timestamp":1663022361000},"page":"1311-1320","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Self-Reported Alcohol, Tobacco, and Recreational Drug Use during Pregnancy on Adverse Pregnancy Outcomes in First-Time Mothers"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-1746","authenticated-orcid":false,"given":"Joanne K.","family":"Daggy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Guise","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"e2022942","DOI":"10.1001\/jamanetworkopen.2020.22942","article-title":"Changes in adult alcohol use and consequences during the COVID-19 pandemic in the US","volume":"3","author":"M S Pollard","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1097\/AOG.0000000000003822","article-title":"Tobacco and nicotine cessation during pregnancy. ACOG Committee Opinion No. 807","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/01.AOG.0000182580.78402.d2","article-title":"Maternal smoking and its association with birth weight","volume":"106","author":"I M Bernstein","year":"2005","journal-title":"Obstet Gynecol"},{"key":"ref4","first-page":"525","article-title":"Association between maternal smoking and low birth weight in Switzerland: the EDEN study","volume":"135","author":"A Chiolero","year":"2005","journal-title":"Swiss Med Wkly"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pedneo.2013.05.005","article-title":"Parental smoking during pregnancy and its association with low birth weight, small for gestational age, and preterm birth offspring: a birth cohort study","volume":"55","author":"T-J Ko","year":"2014","journal-title":"Pediatr 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