{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:47:42Z","timestamp":1792853262664,"version":"4.5.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Individuals with spinocerebellar ataxia type 3 (SCA3) present communication and swallowing disorders, and consequent deterioration in quality of life (QOL).<\/jats:p><jats:p>\n          Objective\u2003To evaluate the impact of a speech therapy rehabilitation program on the QOL of patients with SCA3.<\/jats:p><jats:p>\n          Methods\u2003All participants were randomly assigned to two groups, an intervention group receiving speech therapy (STG) and a control group (CG). The International Cooperative Ataxia Rating Scale scores were 32.4\u2009\u00b1\u200920.2, and the Scale for the Assessment and Rating of Ataxia scores were 11.8\u2009\u00b1\u20098.0. The intervention consisted of a 12-session speech therapy rehabilitation program with oral, pharyngeal, and laryngeal strengthening exercises\u2014the so-called ATAXIA\u2013Myofunctional Orofacial and Vocal Therapy (A-MOVT). They all were submitted to pre- and postintervention evaluations using the World Health Organization's Quality of Life (WHOQOL-BREF) assessment, as well as the Living with Dysarthria (LwD), Quality of Life in Swallowing Disorders (SWAL-QOL), and Food Assessment Tool (EAT-10).<\/jats:p><jats:p>\n          Results\u2003The study sample consisted of 48 patients with SCA3 (STG\u2009=\u200925; CG\u2009=\u200923), mean age was 47.1\u2009\u00b1\u200911.4 years; mean age at symptom onset was 36.9\u2009\u00b1\u200911.3 years; disease duration was 11.9\u2009\u00b1\u200913.3 years. After the 3-month intervention, there were significant changes in the QOL in the STG compared with the CG, when assessed by the LwD (179.12\u2009\u00b1\u200962.55 vs. 129.88\u2009\u00b1\u200951.42, p\u2009&lt;\u20090.001), SWAL-QOL (869.43\u2009\u00b1\u2009153.63 vs. 911.60\u2009\u00b1\u2009130.90, p\u2009=\u20090.010), and EAT-10 (5.16\u2009\u00b1\u20097.55 vs. 2.08\u2009\u00b1\u20093.85, p\u2009=\u20090.018).<\/jats:p><jats:p>\n          Conclusions\u2003Patients with SCA3 should receive continuous speech therapy as part of the A-MOVT program, because therapy helps to improve difficulty swallowing and dysarthria.<\/jats:p>","DOI":"10.1055\/s-0042-1755203","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T23:47:56Z","timestamp":1671493676000},"page":"1017-1025","source":"Crossref","is-referenced-by-count":9,"title":["Effect of speech therapy on quality of life in patients with spinocerebelar ataxia type 3"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-0477","authenticated-orcid":false,"given":"Giovana","family":"Diaf\u00e9ria","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-7878","authenticated-orcid":false,"given":"Silvana","family":"Bommarito","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Fonoaudiologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-9243","authenticated-orcid":false,"given":"Pedro","family":"Braga Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Servi\u00e7o de Neurologia e Neurocirurgia, Fortaleza CE, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-2863","authenticated-orcid":false,"given":"Sung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabe\u00e7a e Pesco\u00e7o, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-317X","authenticated-orcid":false,"given":"Marina","family":"Padovani","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa, Departamento de Fonoaudiologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-1176","authenticated-orcid":false,"given":"Fernanda","family":"Haddad","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabe\u00e7a e Pesco\u00e7o, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-0139","authenticated-orcid":false,"given":"Leonardo","family":"Haddad","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Otorrinolaringologia e Cirurgia de Cabe\u00e7a e Pesco\u00e7o, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-7287","authenticated-orcid":false,"given":"Mariana Callil","family":"Voos","sequence":"additional","affiliation":[{"name":"Universidade Pont\u00edfice Cat\u00f3lica de S\u00e3o Paulo, Faculdade de Ci\u00eancias Humanas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-6021","authenticated-orcid":false,"given":"Hsin Fen","family":"Chien","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina de S\u00e3o Paulo, Departamento de Ortopedia e Traumatologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-8894","authenticated-orcid":false,"given":"Jos\u00e9 Luiz","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-0831","authenticated-orcid":false,"given":"Orlando","family":"Barsottini","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista 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Neuropsiquiatr"},{"issue":"02","key":"ref24","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1590\/s0004-282X2010000200014","article-title":"Translation and validation into Brazilian version of the Scale of the Assessment and Rating of Ataxia (SARA)","volume":"68","author":"P Braga-Neto","year":"2010","journal-title":"Arq Neuropsiquiatr"},{"issue":"05","key":"ref25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/mds.20781","article-title":"Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients","volume":"21","author":"T Schmitz-H\u00fcbsch","year":"2006","journal-title":"Mov Disord"},{"issue":"02","key":"ref26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/s0022-510x(96)00231-6","article-title":"International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome","volume":"145","author":"P Trouillas","year":"1997","journal-title":"J Neurol Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/s0079-6123(03)43034-3","article-title":"Role of the cerebellum in the control and adaptation of gait in health and disease","volume":"143","author":"W T Thach","year":"2004","journal-title":"Prog Brain Res"},{"issue":"04","key":"ref28","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/ane.13384","article-title":"Balance and physical functioning in Spinocerebellar ataxias 3 and 10","volume":"143","author":"K M Konno","year":"2021","journal-title":"Acta Neurol Scand"},{"issue":"03","key":"ref29","first-page":"266","article-title":"[The relation among sleep apnea, snore and mouth breathing]","volume":"6","author":"R CP Burger","year":"2004","journal-title":"Rev CEFAC"},{"issue":"01","key":"ref30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1590\/S0103-21002007000100011","article-title":"[Patients' experience with Parkinson's disease]","volume":"20","author":"L HT 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