{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:25:22Z","timestamp":1772231122679,"version":"3.50.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa Institucional de Bolsas de Inicia\u00e7\u00e3o Cient\u00edfica - PIBIC\/Reitoria\/CNPq\/UNESP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The Parkinson disease (PD) is frequently associated with autonomic dysfunctions. However, data regarding the influence of PD on the autonomic responses to postural changes is limited.<\/jats:p><jats:p>\n          Objective\u2003To analyze and compare the autonomic responses, evaluated through linear and non-linear methods of heart rate variability, and cardiorespiratory parameters in two groups: Parkinson disease (PDG) and control (CG), at rest and during the active tilt test.<\/jats:p><jats:p>\n          Methods\u2003A total of 48 participants were analyzed (PDG: n\u2009=\u200925;73.40\u2009\u00b1\u20097.01 years \/ CG: n\u2009=\u200923;70.17\u2009\u00b1\u20098.20 years). The autonomic modulation and cardiorespiratory parameters were evaluated at rest and during the active tilt test. To assess the autonomic modulation the linear indices, at the time (rMSSD, SDNN) and frequency (LF, HF, LF\/HF) domains, and the non-linear indices, obtained through the Poincar\u00e9 plot (SD1, SD2, SD1\/SD2), were calculated. The cardiorespiratory parameters evaluated were heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP), peripheral oxygen saturation (SpO2), and respiratory rate.<\/jats:p><jats:p>\n          Results\u2003At rest, the PDG presented significantly lower values of rMSSD, SDNN, LF, HF, SD1, SD2, and DBP, and higher values of SpO2. During test, in the PD group, modifications were observed in HR, and SBP, besides a reduced parasympathetic response, and an increased global modulation. The qualitative analysis of the Poincar\u00e9 plot showed that the PDG has a lower dispersion of the RR intervals during rest and the active tilt test.<\/jats:p><jats:p>\n          Conclusion\u2003Individuals with PD present reduced global variability and parasympathetic modulation at rest, and reduced parasympathetic response and damage in HR regulation when performing the active tilt test, compared with controls.<\/jats:p>","DOI":"10.1055\/s-0042-1755225","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:30:24Z","timestamp":1664490624000},"page":"689-698","source":"Crossref","is-referenced-by-count":4,"title":["Autonomic and cardiorespiratory responses to the active tilt test in individuals with Parkinson disease: cross-sectional study"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-1904","authenticated-orcid":false,"given":"Heloisa Balotari","family":"Valente","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3761-4164","authenticated-orcid":false,"given":"Natacha de Lima","family":"Gervazoni","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-9061","authenticated-orcid":false,"given":"Maria J\u00falia Lopez","family":"Laurino","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-3143","authenticated-orcid":false,"given":"La\u00eds Manata","family":"Vanzella","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-2786","authenticated-orcid":false,"given":"Mileide Cristina","family":"Stoco-Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-1294","authenticated-orcid":false,"given":"Mariana Viana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-8735","authenticated-orcid":false,"given":"Larissa Borba","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-4233","authenticated-orcid":false,"given":"Felipe","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-5740","authenticated-orcid":false,"given":"Augusto Cesinando de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-3153","authenticated-orcid":false,"given":"Luiz Carlos Marques","family":"Vanderlei","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d, Faculdade de Ci\u00eancias e Tecnologia, Departamento de Fisioterapia, Presidente Prudente SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"L V Kalia","year":"2015","journal-title":"Lancet"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson's disease","volume":"124","author":"O B Tysnes","year":"2017","journal-title":"J Neural Transm (Vienna)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson 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