{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:28:34Z","timestamp":1793914114840,"version":"4.8.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Radiol Imaging"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radio frequency ablation (RFA) is a minimally invasive technique that has become recognized in clinical practice for treating chondroblastoma, although curettage with bone graft is the standard treatment. Chondroblastoma is a locally aggressive cartilaginous bone tumor, representing nearly 5% of benign bone tumors. Chondroblastoma shows a preference toward the epiphysis or apophysis of long bones, but it was also reported in vertebrae and flat bones. The management of chondroblastoma could be challenging due to the risk to injure the epiphyseal plate or difficult location. The aim of this study was to determine if RFA is a suitable alternative to curettage with bone graft for the treatment of chondroblastoma. Moreover, there will be an evaluation of RFA's effectiveness in terms of symptoms relief; we also define the proper size of the lesion to be treated with RFA, and discuss the complications after the procedure, including the recurrence rate. Furthermore, we review the best imaging method to evaluate the therapeutic response of RFA and for the detection of residual disease early after the ablation. A comprehensive PubMed and Google Scholar search followed the Preferred Reporting Items for Systematic Review and Meta-Analysis 2020 checklist guidelines. Ninety-seven patients were identified after reviewing the available full texts of nine articles. The results of the current review provide further evidence to support the use of RFA as an alternative option to surgery.<\/jats:p>","DOI":"10.1055\/s-0042-1755248","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T22:55:05Z","timestamp":1661900105000},"page":"523-530","source":"Crossref","is-referenced-by-count":10,"title":["Radio Frequency Ablation for the Treatment of Appendicular Skeleton Chondroblastoma: Is It an Excellent Alternative? Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-7126","authenticated-orcid":false,"given":"Sarmad Rasheed Khalil","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, King Salman Medical City, Al Madina Al Munawara Hospital, Medina, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadha Abobakr Mohammed","family":"Al-Zubaidi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Madina Cardiac Centre, Medina, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Abdelsattar","family":"Sakrana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Mansoura University Hospital, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5435\/JAAOS-21-04-225","article-title":"Chondroblastoma and chondromyxoid fibroma","volume":"21","author":"C B De Mattos","year":"2013","journal-title":"J Am Acad Orthop Surg"},{"issue":"06","key":"ref2","first-page":"969","article-title":"Benign chondroblastoma of bone: a reinterpretation of the so-called calcifying or chondromatous giant cell tumor","volume":"18","author":"H L Jaffe","year":"1942","journal-title":"Am J Pathol"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.5858\/arpa.2016-0281-RS","article-title":"Chondroblastoma: an update","volume":"141","author":"W Chen","year":"2017","journal-title":"Arch Pathol Lab Med"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.2106\/JBJS.H.00657","article-title":"Chondroblastoma of bone in a pediatric population","volume":"91","author":"F Sailhan","year":"2009","journal-title":"J Bone Joint Surg Am"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2106\/00004623-198567050-00009","article-title":"Chondroblastoma. A review of seventy cases","volume":"67","author":"D S Springfield","year":"1985","journal-title":"J Bone Joint Surg Am"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/pin.12586","article-title":"Chondroblastoma of extra-craniofacial bones: clinicopathological analyses of 103 cases","volume":"67","author":"E Konishi","year":"2017","journal-title":"Pathol Int"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00256-002-0599-4","article-title":"Vertebral chondroblastoma","volume":"32","author":"H Ilaslan","year":"2003","journal-title":"Skeletal Radiol"},{"issue":"03","key":"ref8","first-page":"128","article-title":"Aggressive scapular chondroblastoma with secondary metastasis\u2013a case report and review of literature","volume":"11","author":"C Kirchhoff","year":"2006","journal-title":"Eur J Med Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1092-9134(03)00048-0","article-title":"Chondroblastoma: varied histologic appearance, potential diagnostic pitfalls, and clinicopathologic features associated with local recurrence","volume":"7","author":"M C de Silva","year":"2003","journal-title":"Ann Diagn Pathol"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00256-011-1227-y","article-title":"Metaphyseal and diaphyseal chondroblastomas","volume":"40","author":"A V Maheshwari","year":"2011","journal-title":"Skeletal Radiol"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/his.13725","article-title":"Histone H3K36M mutation and trimethylation patterns in chondroblastoma","volume":"74","author":"C Lu","year":"2019","journal-title":"Histopathology"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/1097-0142(19850415)55:8<1770::AID-CNCR2820550825>3.0.CO;2-Q","article-title":"Metastatic chondroblastoma. Report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma","volume":"55","author":"M Kyriakos","year":"1985","journal-title":"Cancer"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00330-014-3506-1","article-title":"Radiofrequency ablation of chondroblastoma: long-term clinical and imaging outcomes","volume":"25","author":"C Xie","year":"2015","journal-title":"Eur Radiol"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00256-014-1820-y","article-title":"Image guided radiofrequency thermo-ablation therapy of chondroblastomas: should it replace surgery?","volume":"43","author":"R K Lalam","year":"2014","journal-title":"Skeletal Radiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.jvir.2010.04.008","article-title":"Radiofrequency ablation: mechanism of action and devices","volume":"21","author":"K Hong","year":"2010","journal-title":"J Vasc Interv Radiol"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejrad.2007.03.024","article-title":"Radiofrequency ablation of two femoral head chondroblastomas","volume":"63","author":"T Petsas","year":"2007","journal-title":"Eur J Radiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4329\/wjr.v4.i7.335","article-title":"Bipolar radiofrequency ablation of tibialchondroblastomas: a report of three cases","volume":"4","author":"P Rajalakshmi","year":"2012","journal-title":"World J Radiol"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s00330-005-0022-3","article-title":"Radiofrequency ablation of chondroblastoma using a multi-tined expandable electrode system: initial results","volume":"16","author":"B Tins","year":"2006","journal-title":"Eur Radiol"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/1097-0142(20000601)88:11<2452::AID-CNCR5>3.0.CO;2-3","article-title":"Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation","volume":"88","author":"S N Goldberg","year":"2000","journal-title":"Cancer"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1148\/radiol.2212010262","article-title":"Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases","volume":"221","author":"J K Erickson","year":"2001","journal-title":"Radiology"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1148\/radiol.2512080500","article-title":"Chondroblastoma: radiofrequency ablation\u2013alternative to surgical resection in selected cases","volume":"251","author":"L D Rybak","year":"2009","journal-title":"Radiology"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00256-008-0526-4","article-title":"Radiofrequency ablation of chondroblastoma: procedure technique, clinical and MR imaging follow up of four cases","volume":"37","author":"M Christie-Large","year":"2008","journal-title":"Skeletal Radiol"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jvir.2020.07.027","article-title":"Percutaneous radiofrequency ablation of appendicular skeleton chondroblastoma-an experience from a tertiary care cancer center","volume":"32","author":"S S Kulkarni","year":"2021","journal-title":"J Vasc Interv Radiol"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejrad.2009.06.012","article-title":"Percutaneous treatment of bone tumors by radiofrequency thermal ablation","volume":"77","author":"F Ruiz Santiago","year":"2011","journal-title":"Eur J Radiol"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.2106\/00004623-200008000-00011","article-title":"Chondroblastoma of bone","volume":"82","author":"A J Ramappa","year":"2000","journal-title":"J Bone Joint Surg Am"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00776-007-1141-2","article-title":"Management of chondroblastoma: retrospective review of 28 patients","volume":"12","author":"H Atalar","year":"2007","journal-title":"J Orthop Sci"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1148\/rg.311105033","article-title":"Therapeutic response to radiofrequency ablation of neoplastic lesions: FDG PET\/CT findings","volume":"31","author":"N C Purandare","year":"2011","journal-title":"Radiographics"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1080\/02656736.2019.1687943","article-title":"Radiofrequency ablation of atypical cartilaginous tumors in long bones: a retrospective study","volume":"36","author":"R Rivas","year":"2019","journal-title":"Int J Hyperthermia"},{"issue":"03","key":"ref29","first-page":"520","article-title":"Assessment of liver tissue after radiofrequency ablation: findings with different imaging procedures","volume":"46","author":"G Antoch","year":"2005","journal-title":"J Nucl Med"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/j.jvir.2013.01.450","article-title":"Abstract No. 421 - Role of radiofrequency (RF) ablation as minimally invasive management of chondroblastoma","volume":"24","author":"T P Dharia","year":"2013","journal-title":"J Vasc Interv Radiol"}],"container-title":["Indian Journal of Radiology and Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1755248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:48:16Z","timestamp":1669682896000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1755248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":30,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,11,28]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1755248","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0971-3026","1998-3808"],"issn-type":[{"value":"0971-3026","type":"print"},{"value":"1998-3808","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]}}}