{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:36:28Z","timestamp":1788881788453,"version":"build-2803163510"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Subarachnoid hemorrhage (SAH) is an uncommon and serious subtype of stroke, which leads to the loss of the patient's ability to produce and live for many years.<\/jats:p><jats:p>\n          Objective\u2003To investigate the clinical effect of nimodipine in the treatment of SAH.<\/jats:p><jats:p>\n          Methods\u2003Electronic databases including China National Knowledge Infrastructure (CNKI), VIP, SinoMed, China Master's Theses Full-text Database (CMFD), China Doctoral Dissertations Full-text Database (CDFD), Cochrane Library, PubMed and Embase were searched from 2010 and 2021. All randomized controlled trials evaluating the efficacy of nimodipine in the treatment of SAH were included in our meta-analysis. The patients were divided into control group and treatment group. Meta-analysis was performed with Stata16.0 software.<\/jats:p><jats:p>\n          Results\u2003A total of 10 studies were included. Compared with the control group, the treatment group had higher effective rate (OR\u2009=\u20093.21, 95% CI: 2.25, 4.58; p\u2009&lt;\u20090.001), and lower incidence of adverse reactions (OR\u2009=\u20090.35, 95% CI: 0.19, 0.67; p\u2009=\u20090.001). Before treatment, no significant differences were identified in middle cerebral artery blood flow velocity and Glasgow coma scale (GCS) score between the two groups. However, after treatment, the middle cerebral artery blood flow velocity (SMD\u2009=\u2009\u22121.36, 95% CI: \u22122.28, \u22120.49; p\u2009=\u20090.002) and GCS score (SMD\u2009=\u20091.24, 95% CI: 0.58, 1.89; p\u2009&lt;\u20090.001) in the treatment group were significantly better than those in the control group.<\/jats:p><jats:p>\n          Conclusions\u2003Nimodipine is effective in the treatment of SAH, lowering incidence of adverse reactions and therefore improving the prognosis of patients.<\/jats:p>","DOI":"10.1055\/s-0042-1755301","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:30:24Z","timestamp":1664490624000},"page":"663-670","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of nimodipine in the treatment of subarachnoid hemorrhage: a meta-analysis"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-1275","authenticated-orcid":false,"given":"Jianqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-8120","authenticated-orcid":false,"given":"Cuimei","family":"Sun","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-8051","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-0382","authenticated-orcid":false,"given":"Guangjun","family":"Nie","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0851","authenticated-orcid":false,"given":"Qihao","family":"Dong","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-5111","authenticated-orcid":false,"given":"Jiebing","family":"You","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-7775","authenticated-orcid":false,"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"West Hospital of Zibo Central Hospital, Department of Neurology, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-328X","authenticated-orcid":false,"given":"Mingyue","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University, The Third Affilated Hospital, Department of Rehabilitation Medicine, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJMcp1605827","article-title":"Subarachnoid Hemorrhage","volume":"377","author":"M T Lawton","year":"2017","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.wneu.2019.03.083","article-title":"A Review of the Management of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage","volume":"126","author":"K Li","year":"2019","journal-title":"World Neurosurg"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/STROKEAHA.119.025997","article-title":"Treatment of Spontaneous Subarachnoid Hemorrhage: Guidelines and Gaps","volume":"51","author":"M Maher","year":"2020","journal-title":"Stroke"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/00075198-200204000-00007","article-title":"Therapeutic approaches to vasospasm in subarachnoid hemorrhage","volume":"8","author":"N W Dorsch","year":"2002","journal-title":"Curr Opin Crit Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.drudis.2007.11.010","article-title":"New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage","volume":"13","author":"R W Crowley","year":"2008","journal-title":"Drug Discov Today"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.STR.23.2.205","article-title":"The International Cooperative Study on the Timing of Aneurysm Surgery. The North American experience","volume":"23","author":"E C Haley Jr","year":"1992","journal-title":"Stroke"},{"issue":"02","key":"ref7","first-page":"149","article-title":"Effect of different doses of nimodipine on cerebral vasospasm after subarachnoid hemorrhage","volume":"18","author":"W WH He","year":"2005","journal-title":"J Clin Neurol"},{"issue":"04","key":"ref8","first-page":"568","article-title":"Comparison of Fasudil and Nimodipine in the Treatment of Cerebral Vasospasm after Subarachnoid Hemorrhage","volume":"38","author":"Z LFH Zhao","year":"2010","journal-title":"Medical Science Journal of Central South China."},{"issue":"02","key":"ref9","first-page":"79","article-title":"[Recommendations for the management of patients with aneurysmal subarachnoid hemorrhage]","volume":"66","author":"A Raabe","year":"2005","journal-title":"Zentralbl Neurochir"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0090-3019(97)00290-5","article-title":"Postoperative subarachnoid clots and the pattern of cerebral ischemia associated with symptomatic vasospasm","volume":"49","author":"A Tanaka","year":"1998","journal-title":"Surg Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF01405268","article-title":"Cerebral vasospasm diagnosis by means of angiography and blood velocity measurements","volume":"100","author":"K F Lindegaard","year":"1989","journal-title":"Acta Neurochir (Wien)"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S1474-4422(06)70582-8","article-title":"Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review","volume":"5","author":"M D Vergouwen","year":"2006","journal-title":"Lancet Neurol"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2174\/187152711798072383","article-title":"Meta-analysis of the effectiveness and safety of prophylactic use of nimodipine in patients with an aneurysmal subarachnoid haemorrhage","volume":"10","author":"G J Liu","year":"2011","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"A Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"issue":"03","key":"ref15","first-page":"249","article-title":"[Effect of nimodipine on cerebral vasospasm after subarachnoid hemorrhage]","volume":"9","author":"Y Liu","year":"2014","journal-title":"Neural Injury and Functional Reconstruction."},{"issue":"09","key":"ref16","first-page":"157","article-title":"[Clinical Effects of Nimodipine Combined with Alprostadil in the Treatment of Traumatic Subarachnoid Hemorrhage]","volume":"25","author":"S B Zheng","year":"2017","journal-title":"Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease."},{"issue":"17","key":"ref17","first-page":"52","article-title":"[Effect observation of nimodipine combined with edaravone in treatment of cerebral vasospasm after subarachnoid hemorrhage]","volume":"23","author":"L J Ma","year":"2019","journal-title":"Journal of Clinical Medicine in Practice."},{"issue":"16","key":"ref18","first-page":"2244","article-title":"[Randomized controlled study comparing effect of nimodipine with magnesium sulfate on cerebral vasospasm after sub-arachnoid hemorrhage]","volume":"11","author":"Y Tian","year":"2014","journal-title":"Jianyan Yixue Yu Linchuang"},{"issue":"22","key":"ref19","first-page":"64","article-title":"[Clinical efficacy of Nimodipine for traumatic subarachnoid hemorrhage]","volume":"4","author":"Y B Cao","year":"2014","journal-title":"China Medicine and Pharmacy."},{"issue":"27","key":"ref20","first-page":"29","article-title":"[Clinical analysis on nimodipine in the treatment of traumatic subarachnoid hemorrhage]","volume":"57","author":"Z Y Zhu","year":"2019","journal-title":"China Modern Doctor."},{"issue":"04","key":"ref21","first-page":"315","article-title":"[Clinical Study of Therapeutic Effect of Nimodipine on Traumatic Subarachnoid Hemorrhage]","volume":"39","author":"Y Wang","year":"2011","journal-title":"Tianjin Yi Yao"},{"issue":"03","key":"ref22","first-page":"262","article-title":"[Effects of interventional embolization combined with nimodipine in treatment of aneurysmal subarachnoid hemorrhage and its effect on expression of vascular endothelial factors, inflammatory factors and HMGB]","volume":"16","author":"X F Dong","year":"2019","journal-title":"Journal of Clinical Neurosurgery."},{"issue":"11","key":"ref23","first-page":"1208","article-title":"[Effect of nimodipine on cerebral vasospasm after traumatic subarachnoid hemorrhage]","volume":"36","author":"Y S Cao","year":"2011","journal-title":"J Bengbu Med Coll."},{"issue":"11","key":"ref24","first-page":"45","article-title":"[The Value of Nimodipine in the Treatment of Traumatic Subarachnoid Hemorrhage]","volume":"14","author":"M X Zuo","year":"2017","journal-title":"Drug Evaluation."},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/1591019917732288","article-title":"Higher dose intra-arterial milrinone and intra-arterial combined milrinone-nimodipine infusion as a rescue therapy for refractory cerebral vasospasm","volume":"23","author":"E Duman","year":"2017","journal-title":"Interv Neuroradiol"},{"issue":"08","key":"ref26","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/10641960802580190","article-title":"Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile","volume":"30","author":"F Amenta","year":"2008","journal-title":"Clin Exp Hypertens"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/bmj.298.6674.636","article-title":"Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial","volume":"298","author":"J D Pickard","year":"1989","journal-title":"BMJ"},{"issue":"03","key":"ref28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3171\/jns.1996.84.3.0405","article-title":"Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a metaanalysis","volume":"84","author":"F G Barker II","year":"1996","journal-title":"J Neurosurg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.wneu.2015.11.081","article-title":"Long-Term, Continuous Intra-Arterial Nimodipine Treatment of Severe Vasospasm After Aneurysmal Subarachnoid Hemorrhage","volume":"88","author":"K Hockel","year":"2016","journal-title":"World Neurosurg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3389\/fnins.2018.00724","article-title":"Electroacupuncture Improves Cerebral Vasospasm and Functional Outcome of Patients With Aneurysmal Subarachnoid Hemorrhage","volume":"12","author":"J Sun","year":"2018","journal-title":"Front Neurosci"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1385\/NCC:2:2:110","article-title":"Subarachnoid hemorrhage grading scales: a systematic review","volume":"2","author":"D S Rosen","year":"2005","journal-title":"Neurocrit Care"},{"issue":"19","key":"ref32","doi-asserted-by":"crossref","first-page":"e25815","DOI":"10.1097\/MD.0000000000025815","article-title":"Modified Glasgow coma scale for predicting outcome after subarachnoid hemorrhage surgery","volume":"100","author":"I S Bae","year":"2021","journal-title":"Medicine (Baltimore)"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1755301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:39:29Z","timestamp":1682555969000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1755301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":32,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2022,9,29]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1755301","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}