{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:11:16Z","timestamp":1784157076168,"version":"3.55.0"},"reference-count":143,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Migraine affects 1 billion people worldwide and\u2009&gt;\u200930 million Brazilians; besides, it is an underdiagnosed and undertreated disorder.<\/jats:p><jats:p>Objective\u2003The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience.<\/jats:p><jats:p>Methods\u2003Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy.<\/jats:p><jats:p>Results\u2003From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease.<\/jats:p><jats:p>Conclusions\u2003Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.<\/jats:p>","DOI":"10.1055\/s-0042-1755320","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T23:42:13Z","timestamp":1666136533000},"page":"953-969","source":"Crossref","is-referenced-by-count":12,"title":["Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-4164","authenticated-orcid":false,"given":"Paulo Sergio Faro","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba, Departamento de Neurologia, Setor de Cefaleia e Dor Orofacial, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-1064","authenticated-orcid":false,"given":"Eliana Meire","family":"Melhado","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Padre Albino, Faculdade de Medicina, Departamento de Neurologia, Catanduva SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-0735","authenticated-orcid":false,"given":"Alexandre Ottoni","family":"Kaup","sequence":"additional","affiliation":[{"name":"Houston Headache Clinic, Houston TX, USA."},{"name":"Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP, Brazil."},{"name":"Universidade de Santo Amaro, S\u00e3o Paulo SP, 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