{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:36Z","timestamp":1790790816003,"version":"4.1.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Iran","award":["1397\u2013115"],"award-info":[{"award-number":["1397\u2013115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Pain is an uncomfortable sensation in the body. Kaempferol is a flavonoid with antinociceptive effects. Transient receptor potential (TRP) channels have been characterized in the sensory system.<\/jats:p><jats:p>\n          Objective\u2003This study evaluated the central antinociceptive effect of Kaempferol and possible mechanisms of action of transient receptor potential cation channel subfamily V member 1 (TRPV1).<\/jats:p><jats:p>\n          Methods\u2003Capsaicin as a TRPV agonist (5\u2009\u03bcg\/\u03bcL, intracerebroventricular [ICV]) and capsazepine as its antagonist (10\u2009\u03bcg\/\u03bcL, icv) were used to test the analgesic effect of kaempferol (1.5\u2009mg, ICV). Morphine (10\u2009\u03bcg, ICV) was used as a positive control. The other groups were treated with a combination of kaempferol and capsaicin, kaempferol and capsazepine, and capsaicin and capsazepine. The cannula was implanted in the cerebroventricular area. The tail-flick, acetic acid, and formalin tests were used to assess analgesic activity. For evaluation of antiinflammatory effect, the formalin-induced rat paw edema was used.<\/jats:p><jats:p>\n          Results\u2003Kaempferol significantly decreased pain in the acute pain models, including the tail-flick and the first phase of the formalin test. In the late phase of the formalin test, as a valid model of nociception, capsazepine inhibited the antinociceptive effect of kaempferol.<\/jats:p><jats:p>\n          Conclusions\u2003Kaempferol has an analgesic effect in the acute pain model and can affect inflammatory pain. Also, the TRPV1 channel plays a role in the antinociceptive activity of kaempferol.<\/jats:p>","DOI":"10.1055\/s-0042-1755321","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T23:30:23Z","timestamp":1668036623000},"page":"900-907","source":"Crossref","is-referenced-by-count":15,"title":["Bioflavonoid exerts analgesic and anti-inflammatory effects via transient receptor potential 1 channel in a rat model"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-6100","authenticated-orcid":false,"given":"Mohammad Mahdi","family":"Zarei","sequence":"additional","affiliation":[{"name":"Islamic Azad University, Department of Pharmacology, Karaj, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-5753","authenticated-orcid":false,"given":"Zohreh","family":"Abdolmaleki","sequence":"additional","affiliation":[{"name":"Islamic Azad University, Department of Pharmacology, Karaj, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-5223","authenticated-orcid":false,"given":"Siamak","family":"Shahidi","sequence":"additional","affiliation":[{"name":"University of Medical Sciences, School of Medicine, Department of Physiology, Hamadan, Iran."},{"name":"Hamadan University of Medical Sciences, Neurophysiology Research Center, Hamadan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41586-018-0793-8","article-title":"Identifying the pathways required for coping behaviours associated with sustained pain","volume":"565","author":"T Huang","year":"2019","journal-title":"Nature"},{"issue":"36","key":"ref2","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.15585\/mmwr.mm6736a2","article-title":"Prevalence of chronic pain 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