{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:56:29Z","timestamp":1762005389222},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>\n            Background\u2003Fibrinolysis activation during delivery contributes to postpartum hemorrhage (PPH). Clot lysis time studied with the global fibrinolytic capacity device (GFC\/LT) is a functional test which rapidly assesses fibrinolytic profile. Tranexamic acid (TXA) is an efficient antifibrinolytic therapy.<\/jats:p><jats:p>\n            Methods\u2003We prospectively studied fibrinolysis and coagulation in 33 women included in the TRAAP2 trial, which aimed to assess the impact of TXA in preventing PPH following a cesarean delivery. TXA or placebo was randomly administered after childbirth as part of the TRAAP2 trial's protocol. Fibrinolytic (GFC\/LT, plasma concentration of fibrinolysis activators and inhibitors) and hemostatic parameters were assayed at three sample times (TREF [T-reference] after anesthesia, T15 and T120minutes after TXA, or placebo administration).<\/jats:p><jats:p>\n            Results\u2003All cesarean deliveries were elective. In the placebo group, the clot lysis time assessed with GFC\/LT significantly decreased between TREF and T120, indicating an activated fibrinolysis (44 [interquartile range, IQR: 40\u201348] vs. 34 [IQR: 30\u201336] minutes, p&lt;0.001). In both TXA and placebo groups, significant fluctuations of the plasmatic concentrations of fibrinolytic mediators were noticed over time, suggesting fibrinolysis activation. Clot lysis time measured by GFC\/LT was significantly increased in women of the TXA group as compared with those in the placebo group at T15 (120 [120\u2013120] vs. 36 [34\u201341] minutes, p&lt;0.001) and T120minutes (113 [99\u2013120] vs. 34 [30\u201336] minutes, p&lt;0.001) after drug administration, indicating a decreased in fibrinolysis in those women.<\/jats:p><jats:p>\n            Conclusion\u2003GFC\/LT evidenced fibrinolysis activation during cesarean delivery, linked to a decrease in fibrinolytic inhibitors. GFC\/LT revealed a significant antifibrinolytic effect of TXA compared with placebo. <\/jats:p>","DOI":"10.1055\/s-0042-1755379","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T23:01:57Z","timestamp":1662678117000},"page":"1869-1878","source":"Crossref","is-referenced-by-count":5,"title":["Hemostatic Effects of Tranexamic Acid in Cesarean Delivery: An Ancillary Study of the TRAAP2 Study"],"prefix":"10.1055","volume":"122","author":[{"given":"St\u00e9phanie","family":"Roullet","sequence":"additional","affiliation":[{"name":"P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, CHU Bordeaux, Bordeaux, France"},{"name":"INSERM, Biologie des Maladies Cardiovasculaires, University of Bordeaux, U1034, Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timoth\u00e9e","family":"Rivoire","sequence":"additional","affiliation":[{"name":"P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Houssin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Gyn\u00e9cologie et Obst\u00e9trique, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Labrouche","sequence":"additional","affiliation":[{"name":"INSERM, Biologie des Maladies Cardiovasculaires, University of Bordeaux, U1034, Pessac, France"},{"name":"Laboratoire d'h\u00e9matologie, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Paquin","sequence":"additional","affiliation":[{"name":"P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Nouette-Gaulain","sequence":"additional","affiliation":[{"name":"P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, CHU Bordeaux, Bordeaux, France"},{"name":"INSERM, Maladies Rares: G\u00e9n\u00e9tique et M\u00e9tabolisme, University of Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Deneux-Tharaux","sequence":"additional","affiliation":[{"name":"INSERM, Perinatal Obstetrical and Pediatric Epidemiology Research Team (EPOP\u00e9), Centre for Research on Epidemiology and Statistics (CRESS), Paris University, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Amiral","sequence":"additional","affiliation":[{"name":"SH-Consulting, Andr\u00e9sy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"James","sequence":"additional","affiliation":[{"name":"INSERM, Biologie des Maladies Cardiovasculaires, University of Bordeaux, U1034, Pessac, France"},{"name":"Laboratoire d'h\u00e9matologie, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Sentilhes","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Gyn\u00e9cologie et Obst\u00e9trique, CHU Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejogrb.2015.12.012","article-title":"Postpartum hemorrhage: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF): in collaboration with the French Society of Anesthesiology and Intensive Care (SFAR)","volume":"198","author":"L Sentilhes","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"353.e1","DOI":"10.1016\/j.ajog.2010.01.011","article-title":"Trends in postpartum hemorrhage: United States, 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