{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:08:16Z","timestamp":1784952496552,"version":"3.55.0"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"12","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To evaluate the use of misoprostol prior to hysteroscopy procedures regarding technical ease, the presence of side effects, and the occurrence of complications.<\/jats:p><jats:p>\n          Methods\u2003This is a retrospective, observational, analytical, case-control study, with the review of medical records of 266 patients followed-up at the Gynecological Videoendoscopy Sector of the Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto of the Universidade de S\u00e3o Paulo (HCFMRP \u2013 USP, in the Portuguese acronym) from 2014 to 2019, comparing 133 patients who used the drug before the procedure with 133 patients who did not.<\/jats:p><jats:p>\n          Results\u2003The occurrence of postmenopausal uterine bleeding was the main indication for hysteroscopy and revealed a statistical difference between groups (p\u2009&lt;\u20090.001), being present in 93.23% of the patients in the study group and in 69.7% of the patients in the control group. Only 2 patients (1.5%) in the study group reported adverse effects. Although no statistical differences were observed regarding the occurrence of complications during the procedure (p\u2009=\u20090.0662), a higher total number of complications was noted in the group that used misoprostol (n\u2009=\u20097; 5.26%) compared with the group that did not use the drug (n\u2009=\u20091; 0.75%), a fact that is clinically relevant. When evaluating the ease of the technique (measured by the complete performance of all steps of the hysteroscopy procedure), it was verified that although there was no difference between groups (p\u2009=\u20090.0586), the control group had more than twice as many incompletely performed procedures (n\u2009=\u200917) when compared with the group that used misoprostol previously (n\u2009=\u20098), which is also clinically relevant.<\/jats:p><jats:p>\n          Conclusion\u2003The use of misoprostol prior to hysteroscopy in our service indicated that the drug can facilitate the performance of the procedure, but not without side effects and presenting higher complication rates.<\/jats:p>","DOI":"10.1055\/s-0042-1755462","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T23:01:10Z","timestamp":1661814070000},"page":"1102-1109","source":"Crossref","is-referenced-by-count":5,"title":["Misoprostol Administration Before Hysteroscopy Procedures \u2013 A Retrospective Analysis"],"prefix":"10.61622","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-3377","authenticated-orcid":false,"given":"Qu\u00eanya Antunes Silveira","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-622X","authenticated-orcid":false,"given":"J\u00falia Kefal\u00e1s","family":"Troncon","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-0185","authenticated-orcid":false,"given":"Fernando Passador","family":"Val\u00e9rio","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-3834","authenticated-orcid":false,"given":"Helmer","family":"Herren","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-008X","authenticated-orcid":false,"given":"Ant\u00f4nio Alberto","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-5496","authenticated-orcid":false,"given":"Omero Benedicto Poli","family":"Neto","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-1328","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar Rosa e","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Ginecologia e Obstetr\u00edcia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, 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Allen","year":"2009","journal-title":"Rev Obstet Gynecol"},{"key":"ref9","volume-title":"Estudo randomizado, duplamente mascarado, placebo controlado do uso do misoprostol versus placebo para histeroscopia diagn\u00f3stica em mulheres na p\u00f3s-menopausa [tese]","author":"A A Costa","year":"2006"},{"key":"ref10","volume-title":"O uso de misoprostol em histeroscopia: revis\u00e3o do seu papel em contexto diagn\u00f3stico e cir\u00fargico [monografia]","author":"A R Moreira","year":"2018"},{"issue":"04","key":"ref11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1590\/S0104-42302006000400025","article-title":"Histerossonografia: avalia\u00e7\u00e3o da cavidade uterina com sangramento anormal","volume":"52","author":"L G de Albuquerque","year":"2006","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"01","key":"ref12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jmig.2007.10.014","article-title":"Detection of benign intracavitary lesions in 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A review of 276 cases","volume":"158","author":"R J Gimpelson","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"ref17","volume-title":"Resultados intra e p\u00f3s-operat\u00f3rios e a frequ\u00eancia de complica\u00e7\u00f5es em pacientes pr\u00e9 e p\u00f3s-menopausadas submetidas \u00e0 histeroscopia cir\u00fargica no IMIP [tcc]","author":"A L Bezerra J\u00fanior","year":"2019"},{"issue":"07","key":"ref18","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/1471-0528.16604","article-title":"Cervical dilatation and preparation prior to outpatient hysteroscopy: a systematic review and meta-analysis","volume":"128","author":"P M De Silva","year":"2021","journal-title":"BJOG"},{"issue":"04","key":"ref19","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/AOG.0b013e31822f3c7b","article-title":"Misoprostol in operative hysteroscopy: a systematic review and meta-analysis","volume":"118","author":"A Selk","year":"2011","journal-title":"Obstet 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