{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T21:41:49Z","timestamp":1700948509845},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003We aim to compare the heparin dose regimen in terms of bleeding, reoperation rate due to severe bleeding, and the amount of transfusion of the blood products in patients who underwent surgery for type A aortic dissection (TAAD).<\/jats:p><jats:p>Materials and Methods\u2003Between January 2018 and August 2021, 90 adult patients who underwent for TAAD were included. Primary outcome measures were postoperative bleeding amount and blood product transfusion requirements. Two different protocols performed in TAAD surgery in our clinic. In this pre- and postimplementation study, before October 2019, the standard-dose heparin protocol (SH group) was used and after November 2019, the low-dose heparin protocol (LH group) was used and two groups were compared. Mechanical ventilation duration, length of intensive care unit and hospital stay, postoperative drainage volumes, blood product transfusions, reoperations due to bleeding, and in-hospital mortality rates were recorded.<\/jats:p><jats:p>Results\u2003The dosages of heparin and activated clotting time values, as well as the additional heparin requirement, were significantly different between the two groups (p\u2009&lt;\u20090.001). Standard-dose heparinization was needed only in 33.3% of patients in the LH group. In the SH group, postoperative total drainage and red blood cell (RBC) transfusion were significantly higher than the LH group (p\u2009=\u20090.036 and p\u2009=\u20090.046, respectively).<\/jats:p><jats:p>Conclusion\u2003We found that the low-dose heparin regimen resulted in significantly less postoperative total drainage and RBC transfusion requirement in patients who underwent for TAAD.<\/jats:p>","DOI":"10.1055\/s-0042-1755469","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:53:16Z","timestamp":1660697596000},"page":"616-622","source":"Crossref","is-referenced-by-count":0,"title":["Low-Dose Heparin Protocol in Type A Aortic Dissection Surgeries"],"prefix":"10.1055","volume":"70","author":[{"given":"Levent","family":"Mavioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yuksek Ihtisas Cardiovascular Hospital, Ankara City Hospital Complex, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yuksek Ihtisas Cardiovascular Hospital, Ankara City Hospital Complex, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertekin Utku","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Erol Olcok Research and Training Hospital, Hitit University, Corum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayla Ece","family":"Celikten","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yuksek Ihtisas Cardiovascular Hospital, Ankara City Hospital Complex, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ankara City Hospital Complex, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakki Zafer","family":"Iscan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yuksek Ihtisas Cardiovascular Hospital, Ankara City Hospital Complex, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Ozatik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Yuksek Ihtisas Cardiovascular Hospital, Ankara City Hospital Complex, University of Health Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e001513","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study","volume":"4","author":"M 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