{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:44:55Z","timestamp":1793051095168,"version":"4.5.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003To date, many studies investigated results and prognostic factors of pulmonary metastasectomy (PM) in renal cell cancer (RCC). However, reports concerning repeated resection for patients with recurrent pulmonary metastases (RPM) are limited. In this study, we analyzed safety, efficacy, and prognostic factors for survival after PM focusing on RPM for RCC.<\/jats:p><jats:p>\n          Patients and Methods\u2003Clinical, operative, and follow-up data of patients who underwent PM or RPM for RCC in our institution were retrospectively collected and correlated with each other from January 2005 to December 2019.<\/jats:p><jats:p>\n          Results\u2003Altogether 154 oncological pulmonary resections in curative intention as PM or RPM were performed in 82 and 26 patients. Postoperative complications were similar in both groups (n\u2009=\u200922 [26.8%] vs. 4 [15.4%], p\u2009=\u20090.2). Zero mortality was documented up to the 30th postoperative day. RPM was not associated with decreased 5-year-survival compared with PM (66.2 vs. 57,9%, p\u2009=\u20090.5). Patients who underwent RPM for recurrent lung metastases had a better overall survival in comparison with the other treatments including chemotherapy, radiotherapy, immunotherapy, and best supportive care (p\u2009=\u20090.04). In the multivariate analysis, disease-free survival was identified as an independent prognostic factor for survival (hazard ratio: 0.969, 0.941\u20130.999, p\u2009=\u20090.04).<\/jats:p><jats:p>\n          Conclusion\u2003RPM is a safe and feasible procedure. The resection of recurrent lung metastases shows to prolong survival in comparison with the other therapeutic options for selected patients with RCC.<\/jats:p>","DOI":"10.1055\/s-0042-1755555","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T22:31:13Z","timestamp":1661034673000},"page":"130-137","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of Repeated Resection of Pulmonary Metastases for Renal Cell Cancer"],"prefix":"10.1055","volume":"71","author":[{"given":"Mohamed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ehle","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen-Thao","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurin","family":"Titze","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernward","family":"Passlick","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Grapatsas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"issue":"08","key":"ref1","first-page":"1025","article-title":"[Pulmonary metastasectomy in renal cell carcinoma]","volume":"56","author":"S Macherey","year":"2017","journal-title":"Urologe A"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nrurol.2011.30","article-title":"The role of metastasectomy in metastatic renal cell carcinoma","volume":"8","author":"M Staehler","year":"2011","journal-title":"Nat Rev Urol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1510\/icvts.2008.181065","article-title":"Pulmonary resection for metastasis from renal cell carcinoma","volume":"7","author":"F Chen","year":"2008","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"40","key":"ref4","first-page":"645","article-title":"Surgical intervention for pulmonary metastases","volume":"109","author":"J Pfannschmidt","year":"2012","journal-title":"Dtsch Arztebl Int"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"e001736","DOI":"10.1136\/bmjopen-2012-001736","article-title":"Pulmonary metastasectomy for sarcoma: a systematic review of reported outcomes in the context of Thames Cancer Registry data","volume":"2","author":"T Treasure","year":"2012","journal-title":"BMJ Open"},{"issue":"12","key":"ref6","first-page":"1198","article-title":"Resection for thoracic metastases from sarcoma","volume":"25","author":"Z Kon","year":"2011","journal-title":"Oncology (Williston Park)"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.amjsurg.2010.06.029","article-title":"Evaluation of a new prognostic score (Munich score) to predict long-term survival after resection of pulmonary renal cell carcinoma metastases","volume":"202","author":"G Meimarakis","year":"2011","journal-title":"Am J Surg"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0003-4975(02)03803-1","article-title":"Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma","volume":"74","author":"J Pfannschmidt","year":"2002","journal-title":"Ann Thorac Surg"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.juro.2010.06.096","article-title":"Tumor infiltrated hilar and mediastinal lymph nodes are an independent prognostic factor for decreased survival after pulmonary metastasectomy in patients with renal cell carcinoma","volume":"184","author":"H Winter","year":"2010","journal-title":"J Urol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejcts.2010.05.021","article-title":"Long-term results of surgical resection for pulmonary metastasis from renal cell carcinoma: a 25-year single-institution experience","volume":"39","author":"R Kanzaki","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.athoracsur.2010.05.014","article-title":"Systematic classification of morbidity and mortality after thoracic surgery","volume":"90","author":"A J Seely","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.athoracsur.2004.08.034","article-title":"Can we predict long-term survival after pulmonary metastasectomy for renal cell carcinoma?","volume":"79","author":"S C Murthy","year":"2005","journal-title":"Ann Thorac Surg"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/jso.23593","article-title":"Systematic lymph node dissection in lung metastasectomy of renal cell carcinoma: an 18 years of experience","volume":"109","author":"S Renaud","year":"2014","journal-title":"J Surg Oncol"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10585-020-10056-w","article-title":"Is repeated pulmonary metastasectomy justified?","volume":"37","author":"C Forster","year":"2020","journal-title":"Clin Exp Metastasis"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-5223(97)70397-0","article-title":"Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases","volume":"113","author":"U Pastorino","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.athoracsur.2013.04.047","article-title":"Metastasectomy with standardized lymph node dissection for metastatic renal cell carcinoma: an 11-year single-center experience","volume":"96","author":"N 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Rodr\u00edguez-Fuster","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.athoracsur.2009.03.034","article-title":"Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases","volume":"87","author":"M W Onaitis","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijsu.2017.03.062","article-title":"Prognostic factors for overall survival after lung metastasectomy in renal cell cancer patients: a systematic review and meta-analysis","volume":"41","author":"Y Zhao","year":"2017","journal-title":"Int J Surg"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1378\/chest.84.4.442","article-title":"Pulmonary resection of metastatic renal cell carcinoma","volume":"84","author":"J R 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