{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:49:48Z","timestamp":1781340588756,"version":"3.54.1"},"reference-count":96,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An important aim of viscoelastic testing (VET) is to implement transfusion algorithms based on coagulation test results to help reduce transfusion rates and improve patient outcomes. Establishing a rapid diagnosis and providing timely treatment of coagulopathy is the cornerstone of management of severely bleeding patients in trauma, postpartum hemorrhage, and major surgery. As the nature of acute bleeding and trauma leads to an unstable and tenuous physiologic state, conventional coagulation tests (CCTs) are too slow to diagnose, manage, and also course correct any hemostatic abnormalities that accompany an acute critical illness. Viscoelastic point-of-care tests strongly correlate with results from standard laboratory tests but are designed to enable clinicians to make timely, informed bleeding management decisions when time to intervene is critical. These assays provide an individualized and goal-oriented approach to patient blood management and are increasingly becoming involved in transfusion algorithms. The scope of this review aims to evaluate the current literature on VETs and their impact on actionable outputs in clinical decision making and their relationship to CCT.<\/jats:p>","DOI":"10.1055\/s-0042-1756192","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:59:31Z","timestamp":1664492371000},"page":"785-795","source":"Crossref","is-referenced-by-count":11,"title":["Role of Viscoelastic and Conventional Coagulation Tests for Management of Blood Product Replacement in the Bleeding Patient"],"prefix":"10.1055","volume":"48","author":[{"given":"Eduard","family":"Matkovic","sequence":"additional","affiliation":[{"name":"Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, 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Trauma"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1701-2163(16)35214-8","article-title":"Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009)","volume":"34","author":"D D Rattray","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/bja\/aer342","article-title":"Comparison of thromboelastometry (ROTEM\u00ae) with standard plasmatic coagulation testing in paediatric surgery","volume":"108","author":"T Haas","year":"2012","journal-title":"Br J Anaesth"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1186\/s13054-014-0549-2","article-title":"Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery","volume":"18","author":"A Hincker","year":"2014","journal-title":"Crit Care"},{"issue":"06","key":"ref7","first-page":"294","article-title":"Can thrombelastography predict venous thromboembolic events in patients with severe extremity trauma?","volume":"30","author":"J L Gary","year":"2016","journal-title":"J Orthop Trauma"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/bja\/aen083","article-title":"Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients","volume":"100","author":"A Levrat","year":"2008","journal-title":"Br J Anaesth"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1097\/CCM.0b013e3182281af5","article-title":"Functional definition and characterization of acute traumatic coagulopathy","volume":"39","author":"R Davenport","year":"2011","journal-title":"Crit Care Med"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/TA.0000000000000657","article-title":"2014 Consensus conference on viscoelastic test-based transfusion guidelines for early trauma resuscitation: report of the panel","volume":"78","author":"K Inaba","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1097\/SLA.0000000000002825","article-title":"Data-driven development of ROTEM and TEG algorithms for the management of trauma emorrhage: a prospective observational multicenter study","volume":"270","author":"K Baksaas-Aasen","year":"2019","journal-title":"Ann Surg"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-021-00264-3","article-title":"Trauma-induced coagulopathy","volume":"7","author":"E E Moore","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"S 02","key":"ref13","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1111\/trf.13486","article-title":"Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient","volume":"56","author":"E E Moore","year":"2016","journal-title":"Transfusion"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jamcollsurg.2019.03.015","article-title":"Does tranexamic acid improve clot strength in severely injured patients who have elevated fibrin degradation products and low fibrinolytic activity, measured by thrombelastography?","volume":"229","author":"H B Moore","year":"2019","journal-title":"J Am Coll Surg"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1538-7836.2012.04752.x","article-title":"Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes","volume":"10","author":"C Rourke","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref16","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.injury.2016.11.021","article-title":"Fibrinogen is an independent predictor of mortality in major trauma patients: a five-year statewide cohort study","volume":"48","author":"Z K McQuilten","year":"2017","journal-title":"Injury"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.surg.2011.06.023","article-title":"Viscoelastic clot strength predicts coagulation-related mortality within 15\u2009minutes","volume":"151","author":"M Pezold","year":"2012","journal-title":"Surgery"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/01.ta.0000226739.30655.75","article-title":"Acidosis impairs the coagulation: a thromboelastographic study","volume":"61","author":"M Engstr\u00f6m","year":"2006","journal-title":"J Trauma"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/TA.0000000000000341","article-title":"Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy","volume":"77","author":"H B Moore","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jamcollsurg.2016.01.006","article-title":"Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients","volume":"222","author":"H B Moore","year":"2016","journal-title":"J Am Coll Surg"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/TA.0000000000002165","article-title":"Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays","volume":"86","author":"G R Stettler","year":"2019","journal-title":"J Trauma Acute Care Surg"},{"issue":"06","key":"ref22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/SLA.0000000000001608","article-title":"Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays","volume":"263","author":"E Gonzalez","year":"2016","journal-title":"Ann Surg"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/jth.14447","article-title":"Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: a systematic review and analysis","volume":"17","author":"J D Dias","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1111\/trf.12214","article-title":"Low hemorrhage-related mortality in trauma patients in a level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets","volume":"53","author":"P I Johansson","year":"2013","journal-title":"Transfusion"},{"issue":"03","key":"ref25","first-page":"CD007871","article-title":"Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion","author":"A Afshari","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"03","key":"ref26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jth.14378","article-title":"Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry","volume":"17","author":"N P Juffermans","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"17","key":"ref27","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.3390\/jcm10173946","article-title":"Viscoelastic hemostatic assays for postpartum hemorrhage","volume":"10","author":"A E Liew-Spilger","year":"2021","journal-title":"J Clin Med"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4097\/kja.19169","article-title":"The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management","volume":"72","author":"K G\u00f6rlinger","year":"2019","journal-title":"Korean J Anesthesiol"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1111\/trf.12550","article-title":"Evaluation and management of postpartum hemorrhage: consensus from an international expert panel","volume":"54","author":"R Abdul-Kadir","year":"2014","journal-title":"Transfusion"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/tme.12755","article-title":"Practical approach to transfusion management of post-partum haemorrhage","volume":"31","author":"M G Frigo","year":"2021","journal-title":"Transfus Med"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aja.2017.12.002","article-title":"Amniotic fluid embolism complicated with pulmonary embolism during cesarean section: management with TEE and ROTEM\u00ae","volume":"55","author":"C-H Chen","year":"2017","journal-title":"Asian J Anesthesiol"},{"issue":"02","key":"ref32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijoa.2014.12.009","article-title":"Anaphylaxis-induced hyperfibrinolysis in pregnancy","volume":"24","author":"H T Truong","year":"2015","journal-title":"Int J Obstet Anesth"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0140-6736(17)32455-8","article-title":"Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40\u2008138 bleeding patients","volume":"391","author":"A Gayet-Ageron","year":"2018","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","author":"B Fawole","year":"2017","journal-title":"Lancet"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1051\/ject\/201648194","article-title":"A case of successful thromboelastographic guided resuscitation after postpartum hemorrhage and cardiac arrest","volume":"48","author":"M Hurwich","year":"2016","journal-title":"J Extra Corpor Technol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijoa.2018.09.001","article-title":"Rotational thromboelastometry (ROTEM\u00ae)-guided diagnosis and management of amniotic fluid embolism","volume":"38","author":"J A Loughran","year":"2019","journal-title":"Int J Obstet Anesth"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1182\/blood-2014-04-567891","article-title":"Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study","volume":"124","author":"P W Collins","year":"2014","journal-title":"Blood"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12871-019-0769-8","article-title":"Functional fibrinogen (FLEV-TEG) versus the Clauss method in an obstetric population: a comparative study","volume":"19","author":"A Spasiano","year":"2019","journal-title":"BMC Anesthesiol"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/anae.12859","article-title":"Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage","volume":"70","author":"S Mallaiah","year":"2015","journal-title":"Anaesthesia"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/anae.14628","article-title":"Four years' experience of a ROTEM\u00ae -guided algorithm for treatment of coagulopathy in obstetric haemorrhage","volume":"74","author":"H McNamara","year":"2019","journal-title":"Anaesthesia"},{"issue":"06","key":"ref41","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/01.TA.0000064328.97941.FC","article-title":"A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function","volume":"56","author":"A S Wolberg","year":"2004","journal-title":"J Trauma"},{"issue":"06","key":"ref42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/MBC.0000000000000095","article-title":"Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery?","volume":"25","author":"A D Sharma","year":"2014","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1053\/j.jvca.2005.04.013","article-title":"The kaolin-activated thrombelastograph predicts bleeding after cardiac surgery","volume":"20","author":"I J Welsby","year":"2006","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"06","key":"ref44","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1053\/j.jvca.2012.06.015","article-title":"Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma","volume":"26","author":"K A Tanaka","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref45","first-page":"37","volume-title":"Whole blood assay: thromboelastometry","author":"K G\u00f6rlinger","year":"2016"},{"issue":"04","key":"ref46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/ijlh.12311","article-title":"A comparison of fibrinogen measurement using TEG(\u00ae) functional fibrinogen and Clauss in cardiac surgery patients","volume":"37","author":"S Agarwal","year":"2015","journal-title":"Int J Lab Hematol"},{"issue":"06","key":"ref47","doi-asserted-by":"crossref","first-page":"e002066","DOI":"10.1161\/JAHA.115.002066","article-title":"Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery","volume":"4","author":"M Ranucci","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"04","key":"ref48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/bja\/aeu086","article-title":"Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate","volume":"113","author":"P W Collins","year":"2014","journal-title":"Br J Anaesth"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1053\/j.jvca.2013.05.014","article-title":"Management of hemorrhage in cardiothoracic surgery","volume":"27","author":"K G\u00f6rlinger","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref50","first-page":"7020539","article-title":"Thromboelastography and thromboelastometry in assessment of fibrinogen deficiency and prediction for transfusion requirement: a descriptive review","volume":"2018","author":"H T Peng","year":"2018","journal-title":"BioMed Res Int"},{"issue":"05","key":"ref51","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/aas.12040","article-title":"Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery: a step towards earlier decision making","volume":"57","author":"D Dirkmann","year":"2013","journal-title":"Acta Anaesthesiol Scand"},{"issue":"05","key":"ref52","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1213\/ane.0b013e31819bccb7","article-title":"The effects of platelet transfusions evaluated using rotational thromboelastometry","volume":"108","author":"P Flisberg","year":"2009","journal-title":"Anesth Analg"},{"issue":"04","key":"ref53","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1213\/ANE.0000000000000259","article-title":"The effect and duration of prophylactic platelet transfusions before insertion of a central venous catheter in patients with bone marrow failure evaluated with point-of-care methods and flow cytometry","volume":"119","author":"T Kander","year":"2014","journal-title":"Anesth Analg"},{"issue":"03","key":"ref54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/liv.12038","article-title":"Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion","volume":"33","author":"A Tripodi","year":"2013","journal-title":"Liver Int"},{"issue":"07","key":"ref55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11748-012-0070-y","article-title":"Optimization of thromboelastography-guided platelet transfusion in cardiovascular surgery","volume":"60","author":"K Aoki","year":"2012","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijcard.2017.09.157","article-title":"Fibrinogen levels compensation of thrombocytopenia-induced bleeding following cardiac surgery","volume":"249","author":"M Ranucci","year":"2017","journal-title":"Int J Cardiol"},{"issue":"03","key":"ref57","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.thromres.2015.07.003","article-title":"Reliability of thromboelastometry for detecting the safe coagulation threshold in patients taking acenocoumarol after elective heart valve replacement","volume":"136","author":"A Blasi","year":"2015","journal-title":"Thromb Res"},{"issue":"01","key":"ref58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/ACO.0000000000000025","article-title":"Novel approaches in management of perioperative coagulopathy","volume":"27","author":"K A Tanaka","year":"2014","journal-title":"Curr Opin Anaesthesiol"},{"issue":"06","key":"ref59","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1053\/j.jvca.2019.01.011","article-title":"A comparative study of SEER sonorheometry versus standard coagulation tests, rotational thromboelastometry, and multiple electrode aggregometry in cardiac surgery","volume":"33","author":"E Baryshnikova","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"04","key":"ref60","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1213\/ANE.0000000000004659","article-title":"Multicenter evaluation of the Quantra QPlus system in adult patients undergoing major surgical procedures","volume":"130","author":"D S Groves","year":"2020","journal-title":"Anesth Analg"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"E189","DOI":"10.3390\/jcm9010189","article-title":"Sensitivity of viscoelastic tests to platelet function","volume":"9","author":"M Ranucci","year":"2020","journal-title":"J Clin Med"},{"issue":"10","key":"ref62","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1365-2044.2012.07231.x","article-title":"Platelet mapping as part of modified thromboelastography (TEG\u00ae) in patients undergoing cardiac surgery and cardiopulmonary bypass","volume":"67","author":"N S Weitzel","year":"2012","journal-title":"Anaesthesia"},{"issue":"12","key":"ref63","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1373\/clinchem.2014.226332","article-title":"Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy","volume":"60","author":"B S Karon","year":"2014","journal-title":"Clin Chem"},{"issue":"04","key":"ref64","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1053\/j.jvca.2013.10.010","article-title":"Reappearance of circulating heparin in whole blood heparin concentration-based management does not correlate with postoperative bleeding after cardiac surgery","volume":"28","author":"J Ichikawa","year":"2014","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"22","key":"ref65","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/CIRCULATIONAHA.107.698977","article-title":"Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery","volume":"116","author":"G J Murphy","year":"2007","journal-title":"Circulation"},{"issue":"06","key":"ref66","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/bja\/aex100","article-title":"Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis","volume":"118","author":"G F Serraino","year":"2017","journal-title":"Br J Anaesth"},{"issue":"03","key":"ref67","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/bja\/aex284","article-title":"Optimal patient blood management in cardiac surgery using viscoelastic point-of-care testing","volume":"119","author":"E A Vlot","year":"2017","journal-title":"Br J Anaesth"},{"issue":"03","key":"ref68","first-page":"235","article-title":"The use of viscoelastic haemostatic assays in non-cardiac surgical settings: a systematic review and meta-analysis","volume":"16","author":"M Franchini","year":"2018","journal-title":"Blood Transfus"},{"issue":"02","key":"ref69","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"A Tripodi","year":"2011","journal-title":"N Engl J Med"},{"issue":"01","key":"ref70","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1160\/TH16-06-0450","article-title":"The risk of venous thromboembolism in patients with cirrhosis. A systematic review and meta-analysis","volume":"117","author":"P Ambrosino","year":"2017","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref71","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/jth.15239","article-title":"The concept of rebalanced hemostasis in patients with liver disease: communication from the ISTH SSC working group on hemostatic management of patients with liver disease","volume":"19","author":"T Lisman","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref72","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/TP.0b013e318168fcd4","article-title":"Coagulation defects do not predict blood product requirements during liver transplantation","volume":"85","author":"L Massicotte","year":"2008","journal-title":"Transplantation"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.thromres.2019.03.022","article-title":"Correlation of thromboelastography and thrombin generation assays in warfarin-treated patients","volume":"178","author":"D E Schmidt","year":"2019","journal-title":"Thromb Res"},{"issue":"02","key":"ref74","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5482\/HAMO-14-08-0033","article-title":"Thrombin generation and rotational thromboelastometry in the healthy adult population","volume":"35","author":"T Schneider","year":"2015","journal-title":"Hamostaseologie"},{"issue":"05","key":"ref75","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/jalm\/jfac030","article-title":"Correlation between thrombin generation, standard coagulation assays, and viscoelastic assays for hemostatic assessment in critically ill children","volume":"07","author":"K A Thomas","year":"2022","journal-title":"J Appl Lab Med"},{"issue":"06","key":"ref76","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.thromres.2015.03.021","article-title":"Application of ROTEM to assess hypercoagulability in patients with lung cancer","volume":"135","author":"N A Davies","year":"2015","journal-title":"Thromb Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.thromres.2020.08.046","article-title":"Rotational thromboelastometry to assess hypercoagulability in COVID-19 patients","volume":"196","author":"N van Veenendaal","year":"2020","journal-title":"Thromb Res"},{"issue":"05","key":"ref78","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/lt.23839","article-title":"No increase in blood transfusions during liver transplantation since the withdrawal of aprotinin","volume":"20","author":"N Schofield","year":"2014","journal-title":"Liver Transpl"},{"issue":"09","key":"ref79","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.transproceed.2017.09.025","article-title":"Fibrinolysis in living donor liver transplantation recipients evaluated using thromboelastometry: impact on mortality","volume":"49","author":"T 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