{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T02:10:59Z","timestamp":1758161459788,"version":"3.44.0"},"reference-count":25,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003This study aimed to test whether early oxygenation failure severity categories (absent\/mild\/moderate\/severe) were associated with health-related quality of life (HRQL) deterioration among children who survived sepsis-related acute respiratory failure.<\/jats:p><jats:p>\n          Methods\u2003We performed a secondary analysis of a study of community-acquired pediatric septic shock, Life After Pediatric Sepsis Evaluation. The primary outcome was an adjusted decline in HRQL \u2265 25% below baseline as assessed 3 months following admission. Logistic regression models were built to test the association of early oxygenation failure including covariates of age and nonrespiratory Pediatric Logistic Organ Dysfunction-2 score. Secondarily, we tested if there was an adjusted decline in HRQL at 6 and 12 months and functional status at 28 days.<\/jats:p><jats:p>\n          Results\u2003We identified 291 children who survived to discharge and underwent invasive ventilation. Of those, that 21% (61\/291) had mild oxygenation failure, 20% (58\/291) had moderate, and 17% (50\/291) had severe oxygenation failure. Fifteen percent of children exhibited a decline in HRQL of at least 25% from their baseline at the 3-month follow-up time point. We did not identify an association between the adjusted severity of oxygenation failure and decline in HRQL \u2265 25% at 3-, 6-, or 12-month follow-up. Children with oxygenation failure were more likely to exhibit a decline in functional status from baseline to hospital discharge, but results were similar across severity categories.<\/jats:p><jats:p>\n          Conclusion\u2003Our findings that children of all oxygenation categories are at risk of HRQL decline suggest that those with mild lung injury should not be excluded from comprehensive follow-up, but more work is needed to identify those at the highest risk.<\/jats:p>","DOI":"10.1055\/s-0042-1756307","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T21:02:25Z","timestamp":1663189345000},"page":"408-414","source":"Crossref","is-referenced-by-count":0,"title":["Oxygenation Severity Categories and Long-Term Quality of Life among Children who Survive Septic Shock"],"prefix":"10.53391","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-2759","authenticated-orcid":false,"given":"Joseph G.","family":"Kohne","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States"},{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan School of Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin F.","family":"Carlton","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States"},{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan School of Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Gorga","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Acham","family":"Gebremariam","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan School of Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Quasney","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children's Hospital, Seattle Children's Research Institute, University of Washington School of Medicine, Seattle, Washington, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Reeves","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan School of Medicine, Ann Arbor, Michigan, United States"},{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan P.","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States"},{"name":"Susan B. Meister Child Health Evaluation and Research Center, University of Michigan School of Medicine, Ann Arbor, Michigan, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/PCC.0000000000000432","article-title":"Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference","volume":"16","author":"R G Khemani","year":"2015","journal-title":"Pediatr Crit Care Med"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/CCM.0000000000002958","article-title":"Risk stratification using oxygenation in the first 24\u2009hours of pediatric acute respiratory distress syndrome","volume":"46","author":"N Yehya","year":"2018","journal-title":"Crit Care Med"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/rccm.200404-544OC","article-title":"Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality","volume":"171","author":"H R Flori","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1097\/PCC.0000000000000438","article-title":"The outcomes of children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference","volume":"16","author":"M W Quasney","year":"2015","journal-title":"Pediatr Crit Care Med"},{"issue":"18","key":"ref5","first-page":"1","article-title":"Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study","volume":"2600","author":"R G Khemani","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/CCM.0000000000004122","article-title":"Critical illness factors associated with long-term mortality and health-related quality of life morbidity following community-acquired pediatric septic shock","volume":"48","author":"J J Zimmerman","year":"2020","journal-title":"Crit Care Med"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1542\/peds.2013-3875","article-title":"Pediatric medical complexity algorithm: a new method to stratify children by medical complexity","volume":"133","author":"T D Simon","year":"2014","journal-title":"Pediatrics"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/CCM.0000000000004123","article-title":"Trajectory of mortality and health-related quality of life morbidity following community-acquired pediatric septic shock","volume":"48","author":"J J Zimmerman","year":"2020","journal-title":"Crit Care Med"},{"issue":"09","key":"ref9","doi-asserted-by":"crossref","first-page":"e686","DOI":"10.1097\/PCC.0000000000002418","article-title":"Severe acute kidney injury is associated with increased risk of death and new morbidity after pediatric septic shock","volume":"21","author":"M C Starr","year":"2020","journal-title":"Pediatr Crit Care Med"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","article-title":"The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity","volume":"3","author":"J W Varni","year":"2003","journal-title":"Ambul Pediatr"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/00005650-199011000-00006","article-title":"Functional status II(R). A measure of child health status","volume":"28","author":"R EK Stein","year":"1990","journal-title":"Med Care"},{"issue":"09","key":"ref12","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/PCC.0000000000000250","article-title":"Pediatric intensive care outcomes: development of new morbidities during pediatric critical care","volume":"15","author":"M M Pollack","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1542\/peds.2008-1987","article-title":"Functional Status Scale: new pediatric outcome measure","volume":"124","author":"M M Pollack","year":"2009","journal-title":"Pediatrics"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/PCC.0000000000000184","article-title":"Nonrespiratory Pediatric Logistic Organ Dysfunction-2 score is a good predictor of mortality in children with acute respiratory failure","volume":"15","author":"F Leclerc","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/CCM.0b013e31828a2bbd","article-title":"PELOD-2: an update of the Pediatric Logistic Organ Dysfunction score","volume":"41","author":"S Leteurtre","year":"2013","journal-title":"Crit Care Med"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1097\/PCC.0000000000001070","article-title":"Long-term function after pediatric critical illness: results from the survivor outcomes study","volume":"18","author":"N P Pinto","year":"2017","journal-title":"Pediatr Crit Care Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.resuscitation.2019.03.020","article-title":"Relationships between three and twelve month outcomes in children enrolled in the therapeutic hypothermia after pediatric cardiac arrest trials","volume":"139","author":"B S Slomine","year":"2019","journal-title":"Resuscitation"},{"issue":"07","key":"ref18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1164\/rccm.201810-1881OC","article-title":"Risk factors for functional decline and impaired quality of life after pediatric respiratory failure","volume":"200","author":"R S Watson","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/PCC.0000000000001886","article-title":"Health-related quality of life among survivors of pediatric sepsis","volume":"20","author":"E Y Killien","year":"2019","journal-title":"Pediatr Crit Care Med"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/PCC.0000000000001476","article-title":"Conceptualizing post intensive care syndrome in children-the PICS-p Framework","volume":"19","author":"J C Manning","year":"2018","journal-title":"Pediatr Crit Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-21840-9_4","volume-title":"Risk factors and etiologies of pediatric acute respiratory distress syndrome","author":"J G Kohne","year":"2020"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/EDE.0000000000000409","article-title":"Selection bias due to loss to follow up in cohort studies","volume":"27","author":"C J Howe","year":"2016","journal-title":"Epidemiology"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11749-009-0138-x","article-title":"Missing data methods in longitudinal studies: a review","volume":"18","author":"J G Ibrahim","year":"2009","journal-title":"Test"},{"issue":"09","key":"ref24","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.4187\/respcare.07461","article-title":"Participant retention in follow-up studies of acute respiratory failure survivors","volume":"65","author":"K Nunna","year":"2020","journal-title":"Respir Care"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MCC.0000000000000650","article-title":"Challenges in conducting long-term outcomes studies in critical care","volume":"25","author":"M E Wilcox","year":"2019","journal-title":"Curr Opin Crit Care"}],"container-title":["Journal of Pediatric Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1756307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:50:31Z","timestamp":1758138631000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1756307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":25,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,11,22]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1756307","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2146-4618","2146-4626"],"issn-type":[{"type":"print","value":"2146-4618"},{"type":"electronic","value":"2146-4626"}],"subject":[],"published":{"date-parts":[[2022,9,14]]}}}