{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:56:39Z","timestamp":1783986999314,"version":"3.55.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenal oncocytomas are rare tumors that are mostly benign and non-functional although they may be hormonally active and can exhibit a borderline or malignant potential. We present a case of a 40-year-old female patient with known hypertension who presented with abdominal discomfort. Radiologic investigations showed a large mass on the left adrenal gland. In the hormonal study, an aldosterone-secreting tumor was identified. After laparoscopic resection, the histological assessment of the 12-cm mass showed an oncocytic neoplasm with borderline characteristics. The laboratory results returned to normal and the hypertensive disease improved. The patient was doing well after 14 months of follow-up. This is the seventh documented case of aldosterone-secreting oncocytoma, the first borderline tumor of this type, and the largest reported tumor so far.<\/jats:p>","DOI":"10.1055\/s-0042-1756675","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T22:52:58Z","timestamp":1663282378000},"page":"182-185","source":"Crossref","is-referenced-by-count":2,"title":["Aldosterone-Secreting Large Oncocytic Neoplasm of the Adrenal Gland with Borderline Potential"],"prefix":"10.1055","volume":"12","author":[{"given":"Maher","family":"Alshaheen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bahrain Specialist Hospital, Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishanu","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology, Bahrain Specialist Hospital. Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Jean","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bahrain Specialist Hospital, Manama, Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-1640","authenticated-orcid":false,"given":"Mhd Firas","family":"Safadi","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1097\/PAS.0b013e31822da401","article-title":"Oncocytic adrenocortical tumors: diagnostic algorithm and mitochondrial DNA profile in 27 cases","volume":"35","author":"E Duregon","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.humpath.2010.08.010","article-title":"Oncocytic adrenocortical neoplasms\u2013a clinicopathologic study of 13 new cases emphasizing the importance of their recognition","volume":"42","author":"D D Wong","year":"2011","journal-title":"Hum Pathol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/106689690401200304","article-title":"Adrenocortical oncocytic tumors: report of 10 cases and review of the literature","volume":"12","author":"M Bisceglia","year":"2004","journal-title":"Int J Surg Pathol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1210\/jc.2014-3182","article-title":"Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection","volume":"100","author":"F Beuschlein","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.12659\/AJCR.910259","article-title":"Laparoscopic trans-abdominal right adrenalectomy for a large primitive adrenal oncocytic carcinoma: a case report and review of literature","volume":"19","author":"V Panizzo","year":"2018","journal-title":"Am J Case Rep"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12022-007-9000-4","article-title":"Functional oncocytic adrenocortical carcinoma","volume":"18","author":"A E Ali","year":"2007","journal-title":"Endocr Pathol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12022-009-9082-2","article-title":"Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions","volume":"20","author":"O Mete","year":"2009","journal-title":"Endocr Pathol"},{"issue":"11","key":"ref8","first-page":"2149","article-title":"High rate of detection of primary aldosteronism, including surgically treatable forms, after \u2018non-selective\u2019 screening of hypertensive patients","volume":"21","author":"M Stowasser","year":"2003","journal-title":"J Hypertens"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"1470320316657450","DOI":"10.1177\/1470320316657450","article-title":"Aldosterone\/direct renin concentration ratio as a screening test for primary aldosteronism: a meta-analysis","volume":"17","author":"X Li","year":"2016","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.epsc.2014.08.002","article-title":"The first laparoscopic resection of an aldosterone-secreting adrenocortical oncocytoma in a child","volume":"2","author":"M Akin","year":"2014","journal-title":"J Pediatr Surg Case Rep"}],"container-title":["Avicenna Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1756675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T23:27:09Z","timestamp":1727998029000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1756675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":10,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,12,21]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1756675","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2231-0770","2249-4464"],"issn-type":[{"value":"2231-0770","type":"print"},{"value":"2249-4464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]}}}