{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:06:56Z","timestamp":1787843216321,"version":"build-2784847793"},"reference-count":80,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Observational studies indicate a relationship between vitamin D deficiency and an increased risk of venous and arterial thrombotic events, but the underlying mechanisms behind this association are uncertain. This systematic review explores if there is an association between decreased vitamin D levels and a prothrombotic profile. The systematic literature search initially identified 3,214 studies (published until December 21, 2021) investigating the relationship between vitamin D and numerous hemostatic parameters. After the screening process, 18 observational and intervention studies fulfilled the inclusion criteria and were included in this systematic review. Parameters of primary hemostasis, secondary hemostasis, and fibrinolysis were investigated in six, thirteen, and fifteen of these studies, respectively. Most of the eligible studies did not identify significant associations between decreased vitamin D levels and hemostatic parameters. Some conflicting results were found between decreased vitamin D levels and thrombin generation parameters and the tissue factor pathway inhibitor. Conflicting results were also found between decreased vitamin D levels and fibrinolytic parameters, although the evidence may point toward weak associations with some regulators of fibrinolysis, mostly decreased tissue type plasminogen activator. Overall, our systematic review did not identify any definitive link between vitamin D deficiency and a prothrombotic profile, which might otherwise help explain the observed association between vitamin D deficiency and increased risk of thrombotic events. Moreover, there is no clinical evidence to confirm or refute a possible antithrombotic effect of vitamin D. Larger high-quality randomized controlled trials are needed to better elucidate the link between vitamin D deficiency and a prothrombotic risk profile.<\/jats:p>","DOI":"10.1055\/s-0042-1756701","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:59:31Z","timestamp":1664492371000},"page":"453-470","source":"Crossref","is-referenced-by-count":6,"title":["Is Vitamin D Deficiency Prothrombotic? A Systematic Review"],"prefix":"10.1055","volume":"49","author":[{"given":"Isabella Hangaard","family":"R\u00fcdiger","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Regional Hospital of Randers, Randers, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde Kanstrup","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Regional Hospital of Randers, Randers, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Louise","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Regional Hospital of Randers, Randers, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnete","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Thrombosis Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Vakur","family":"Bor","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Thrombosis Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Clinical Biochemistry, University Hospital of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention","volume":"18","author":"M F Holick","year":"2017","journal-title":"Rev Endocr Metab Disord"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"M F Holick","year":"2007","journal-title":"N Engl J Med"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.autrev.2013.02.004","article-title":"Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence","volume":"12","author":"P Pludowski","year":"2013","journal-title":"Autoimmun Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"102579","DOI":"10.1016\/j.ctim.2020.102579","article-title":"Association between serum vitamin D levels and venous thromboembolism (VTE): a systematic review and meta-analysis of observational studies","volume":"54","author":"J Wan","year":"2020","journal-title":"Rev Complement Therap Med"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3109\/09286586.2015.1012271","article-title":"Seasonality and incidence of central retinal vein occlusion in Sweden: a 6-year study","volume":"22","author":"D Epstein","year":"2015","journal-title":"Ophthalmic Epidemiol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1538-7836.2009.03312.x","article-title":"Does an active sun exposure habit lower the risk of venous thrombotic events? 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