{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:30:55Z","timestamp":1758814255496},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n            Objective\u2003Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy has been associated with poor pregnancy outcomes. There is, however, not much information on the impact of the timing of SARS-CoV-2 infection on pregnancy outcomes, and studies from low-middle income settings are also scarce.<\/jats:p><jats:p>\n            Study Design We conducted a cross-sectional study from April to December 2020, in South Africa, to assess the association of SARS-CoV-2 infection on a nasal swab at the time of labor with fetal death, preterm birth, low birth weight, or pregnancy-induced complications. When possible, maternal blood, cord blood, and placenta were collected. SARS-CoV-2 infection was investigated by a nucleic acid amplification test (NAAT).<\/jats:p><jats:p>\n            Results Overall, 3,117 women were tested for SARS-CoV-2 on a nasal swab, including 1,562 (50%) healthy women with uncomplicated term delivery. A positive NAAT was detected among 132 (4%) women. Adverse birth outcomes or pregnancy-related complications were not associated with SARS-CoV-2 infection at the time of labor. Among SARS-CoV-2-infected women, an NAAT-positive result was also obtained from 6 out of 98 (6%) maternal blood samples, 8 out of 93 (9%) cord-blood samples, 14 out of 54 (26%) placentas, and 3 out of 22 (14%) nasopharyngeal swabs from newborns collected within 72\u2009hours of birth. Histological assessment of placental tissue revealed that women with SARS-CoV-2 nasal infection had a higher odds (3.82, 95% confidence interval: 1.20, 12.19) of chronic chorioamnionitis compared with those without SARS-CoV-2 infection.<\/jats:p><jats:p>\n            Conclusion\u2003Our study demonstrates that intrapartum, SARS-CoV-2 infection was not associated with evaluated poor outcomes. In utero fetal and placental infections and possible vertical and\/or horizontal viral transfer to the newborn were detected among women with nasal SARS-CoV-2 infection.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0042-1757274","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T19:35:36Z","timestamp":1666985736000},"page":"S42-S48","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Active Intrapartum SARS-CoV-2 Infection and Pregnancy Outcomes"],"prefix":"10.1055","volume":"39","author":[{"given":"Marta C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Jones","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Strehlau","sequence":"additional","affiliation":[{"name":"Nkanyezi Research Unit Sub-Division of VIDA, Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vuyelwa","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zanele","family":"Ditse","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"da Silva","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan\u00e9","family":"Bothma","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natali","family":"Serafin","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky L.","family":"Baillie","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Kwatra","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Burke","sequence":"additional","affiliation":[{"name":"Nkanyezi Research Unit Sub-Division of VIDA, Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philiswa","family":"Mlandu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mpolokeng","family":"Melamu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Phelp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Fraser","sequence":"additional","affiliation":[{"name":"Lancet Laboratories, Johannesburg, Gauteng, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Wright","sequence":"additional","affiliation":[{"name":"Lancet Laboratories, Johannesburg, Gauteng, South Africa"},{"name":"Division of Anatomical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Zell","sequence":"additional","affiliation":[{"name":"Stat-Epi Associates, Inc., Ponte Vedra Beach, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabir A.","family":"Madhi","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines, and Infectious Diseases Analytics (VIDA) Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology\/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"m3320","DOI":"10.1136\/bmj.m3320","article-title":"Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis","volume":"370","author":"J Allotey","year":"2020","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"05018","DOI":"10.7189\/jogh.11.05018","article-title":"A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity","volume":"11","author":"Z S Lassi","year":"2021","journal-title":"J Glob Health"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamapediatrics.2021.1050","article-title":"Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 Infection: the INTERCOVID multinational cohort study","volume":"175","author":"J Villar","year":"2021","journal-title":"JAMA Pediatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"m2107","DOI":"10.1136\/bmj.m2107","article-title":"Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study","volume":"369","author":"M Knight","year":"2020","journal-title":"BMJ"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"e2029256","DOI":"10.1001\/jamanetworkopen.2020.29256","article-title":"Pregnancy outcomes among women with and without severe acute respiratory syndrome coronavirus 2 infection","volume":"3","author":"E H Adhikari","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"e217523","DOI":"10.1001\/jamanetworkopen.2021.7523","article-title":"Association of maternal perinatal SARS-CoV-2 infection with neonatal outcomes during the COVID-19 pandemic in Massachusetts","volume":"4","author":"A Angelidou","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"44","key":"ref7","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.15585\/mmwr.mm6944e2","article-title":"Birth and infant outcomes following laboratory-confirmed SARS-CoV-2 infection in pregnancy\u2014SET-NET, 16 jurisdictions, March 29-October 14, 2020","volume":"69","author":"K R Woodworth","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"e0253974","DOI":"10.1371\/journal.pone.0253974","article-title":"COVID-19 and pregnancy: an umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes","volume":"16","author":"A Ciapponi","year":"2021","journal-title":"PLoS One"},{"issue":"02","key":"ref9","first-page":"1","article-title":"Clinical features and outcomes of COVID-19 infection among pregnant women in South Africa","volume":"10","author":"J K Basu","year":"2021","journal-title":"Int J MCH AIDS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejogrb.2020.11.068","article-title":"Maternal, fetal and neonatal outcomes of large series of SARS-CoV-2 positive pregnancies in peripartum period: a single-center prospective comparative study","volume":"257","author":"N Hcini","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3201\/eid2608.201246","article-title":"US CDC real-time reverse transcription PCR panel for detection of severe acute respiratory syndrome coronavirus 2","volume":"26","author":"X Lu","year":"2020","journal-title":"Emerg Infect Dis"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"e1170","DOI":"10.1093\/cid\/ciaa1873","article-title":"Association of Group B streptococcus serum serotype-specific anti-capsular IgG concentration and risk reduction for invasive Group B streptococcus disease in South African infants: an observational birth-cohort, matched case-control study","volume":"73","author":"S A Madhi","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement","volume":"140","author":"T Y Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/aogs.13870","article-title":"Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates","volume":"99","author":"P S Shah","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0140-6736(20)31714-1","article-title":"Seroprevalence and presentation of SARS-CoV-2 in pregnancy","volume":"396","author":"F Crovetto","year":"2020","journal-title":"Lancet"},{"issue":"08","key":"ref16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.molmed.2022.04.012","article-title":"COVID-19 vaccines in pregnancy","volume":"28","author":"M C Nunes","year":"2022","journal-title":"Trends Mol Med"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T21:17:16Z","timestamp":1671484636000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1757274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":16,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2022,12,19]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757274","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published":{"date-parts":[[2022,10,28]]}}}