{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:13Z","timestamp":1740126853416,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The usefulness of autologous pericardium treated with glutaraldehyde (GA) for tracheal defect closure is unknown. This study preliminarily evaluated whether a GA-treated autologous pericardial graft can effectively close tracheal defects in a beagle model.<\/jats:p><jats:p>\n          Methods\u2003Defects of 10\u2009mm\u2009\u00d7\u200910\u2009mm were created on the trachea of 10 beagles and divided into a GA-treated group (n\u2009=\u20095), with tracheal reconstruction using GA-treated pericardium, and control group (n\u2009=\u20095), using fresh pericardium. Repair sites were evaluated through bronchoscopy and histology. Blood flows on graft were measured using laser Doppler technique on postoperative days (PODs) 0, 4, 7, 14, 28, and 56. Repair sites were histologically evaluated on POD 56. In addition, GA-treated pericardia of three other beagles were histologically evaluated 12 months postoperatively, for long-term follow-up.<\/jats:p><jats:p>\n          Results\u2003All animals survived; none developed anastomotic insufficiency. The mean suturing time and frequency of additional suture were significantly shorter and lower in the GA-treated group than in the control group (p\u2009=\u20090.002, 0.004). All animals in the control group exhibited graft contraction, whereas the GA-treated group healed with most graft residual and reepithelialization in the bronchoscopic and histological findings (p\u2009=\u20090.01, 0.004). Further, all long-term GA-treated pericardia of three beagles were confirmed as residual grafts with reepithelialization, without contraction, at 12 months postoperatively. Blood flows on graft using laser Doppler technique in the GA-treated group were detected at POD 14 or thereafter.<\/jats:p><jats:p>\n          Conclusion\u2003GA-treated pericardium was easier to handle and provided favorable scaffolding, without graft contraction, compared with the nontreated pericardium at short- and long-term follow-up.<\/jats:p>","DOI":"10.1055\/s-0042-1757301","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T23:38:11Z","timestamp":1665445091000},"page":"490-496","source":"Crossref","is-referenced-by-count":0,"title":["Partial Tracheal Defects Closure using Glutaraldehyde-Treated Autologous Pericardium"],"prefix":"10.1055","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-8664","authenticated-orcid":false,"given":"Shuhei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akishi","family":"Oi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Kanazawa University, Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1052-3359(03)00002-4","article-title":"The history of tracheal surgery","volume":"13","author":"H C Grillo","year":"2003","journal-title":"Chest Surg Clin N Am"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0003-4975(03)01462-0","article-title":"Closure of large intrathoracic airway defects using extrathoracic muscle flaps","volume":"77","author":"A J Meyer","year":"2004","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0022-5223(19)38288-1","article-title":"Tracheoplasty with pericardial patch for extensive tracheal stenosis in infants and children","volume":"88","author":"F S Idriss","year":"1984","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0003-4975(00)02327-4","article-title":"Valvuloplasty with glutaraldehyde-treated autologous pericardium in patients with complex mitral valve pathology","volume":"71","author":"C K Ng","year":"2001","journal-title":"Ann Thorac Surg"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1253\/circj.CJ-13-1335","article-title":"Reconstruction of bicuspid aortic valve with autologous pericardium\u2013usefulness of tricuspidization","volume":"78","author":"S Ozaki","year":"2014","journal-title":"Circ J"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1253\/circj.CJ-16-0888","article-title":"Outcomes of totally endoscopic atrial septal defect closure using a glutaraldehyde-treated autologous pericardial patch","volume":"81","author":"H Nishida","year":"2017","journal-title":"Circ J"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0142-9612(82)90056-4","article-title":"A study of the effects of glutaraldehyde and formaldehyde on the mechanical behaviour of bovine pericardium","volume":"3","author":"R van Noort","year":"1982","journal-title":"Biomaterials"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-5223(19)36548-1","article-title":"Valve extension with glutaraldehyde-preserved autologous pericardium. 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