{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:11Z","timestamp":1787004911147,"version":"build-2736575974"},"reference-count":23,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective\u2003Coagulase-negative staphylococci (CoNS) are being implicated as one of the leading causes of bloodstream infection (BSI). To study the spectrum, prevalence, and antimicrobial susceptibility of CoNS causing BSI in neonates.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003A cross-sectional study was done in level III neonatal intensive care unit (NICU). Blood samples in automated culture bottles were processed as per the standard technique. Previously validated methods were followed for the characterization of CoNS and for AST of standard antibiotics by Kirby Bauer disk diffusion and vancomycin by agar dilution. The prevalence of causative organisms and susceptibility of CoNS were statistically analyzed. Categorical variables were compared by chi-square or Fisher's exact probability tests.<\/jats:p>\n                  <jats:p>Result\u2003In total, 1,365 blood samples (1,365 neonates) were studied, of which 383 (28.05%) were positive and 982 (71.94%) were negative. Gram-positive organisms (GPC) predominated (n\u2009=\u2009238; 62.14%) (p\u2009&lt;\u20090.001) with 41.77% (160\/383) S. aureus and 13.83% (53\/383) CoNS. CoNS included S. epidermidis (19, 38%), S. haemolyticus (7, 14%), S. hominis (6, 12%), S. simulans (6,12%), S. capitis (5,10%), S. cohnii (4, 8%), S. warneri (1, 2%), and S. xylosus (1, 2%). The susceptibility to netilmicin, linezolid, and vancomycin was 100% (p \u2264 0.001), and 54% (n\u2009=\u200927) had vancomycin MIC of 0.125\u2009\u03bcg\/mL but methicillin-resistant CoNS (MRCoNS) was 70%. Methicillin-susceptible (MS) CoNS had lower MIC of vancomycin (p\u2009&lt;\u20090.05) than MRCoNS.<\/jats:p>\n                  <jats:p>Conclusion\u2003The spectrum of pathogens causing BSI in neonates is changing with predominance of GPC and among CoNS, S. epidermidis. Considerable proportion of MRCoNS with the emergence of MIC creep for vancomycin requires immediate attention.<\/jats:p>","DOI":"10.1055\/s-0042-1757411","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T19:05:12Z","timestamp":1675105512000},"page":"126-130","source":"Crossref","is-referenced-by-count":8,"title":["Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?"],"prefix":"10.25259","volume":"15","author":[{"given":"Farheen","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-2842","authenticated-orcid":false,"given":"Tuhina","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shampa","family":"Anupurba","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1086\/660361","article-title":"Coagulase-negative staphylococcal infections in the neonatal intensive care unit","volume":"32","author":"N Jean-Baptiste","year":"2011","journal-title":"Infect Control Hosp 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