{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:23:25Z","timestamp":1788971005115,"version":"build-2803163510"},"reference-count":5,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Primary malignant germ cell tumor (GCT) of the mediastinum is a rare entity with an incidence ranging from 1 to 2% of all childhood cancers. Though a few cases of bone metastasis from mediastinal GCTs have been reported, synchronous whole sternal metastasis from primary malignant mediastinal GCTs is very rare. We report such a rare manifestation in a teenager, emphasizing the need for a multidisciplinary treatment approach with neoadjuvant chemotherapy, surgical expertise for en bloc excision of the mediastinal mass along with whole sternal resection, and reconstruction in a dedicated cancer care center for better oncological outcomes.<\/jats:p>","DOI":"10.1055\/s-0042-1757426","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T20:04:21Z","timestamp":1667419461000},"page":"220-223","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous Whole Sternal Metastasis from Primary Malignant Mediastinal Germ Cell Tumor in a Teenager"],"prefix":"10.25259","volume":"13","author":[{"given":"Vasudeva K.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-8782","authenticated-orcid":false,"given":"Kalasekhar","family":"Vijayasekharan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaz","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-1500","authenticated-orcid":false,"given":"Naveena A.N.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3109\/08880018.2012.713084","article-title":"Mediastinal germ cell tumors in childhood","volume":"29","author":"B Yal\u00e7\u0131n","year":"2012","journal-title":"Pediatr Hematol Oncol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/annonc\/mdw648","article-title":"Impact of primary metastatic bone disease in germ cell tumors: results of an International Global Germ Cell Tumor Collaborative Group G3 Registry Study","volume":"28","author":"C Oing","year":"2017","journal-title":"Ann Oncol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00383-016-4020-0","article-title":"Long-term outcomes of pediatric and adolescent mediastinal germ cell tumors: a single pediatric oncology institutional experience","volume":"33","author":"D F Grabski","year":"2017","journal-title":"Pediatr Surg Int"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.athoracsur.2003.08.053","article-title":"Sternal resection and reconstruction for primary malignant tumors","volume":"77","author":"A R Chapelier","year":"2004","journal-title":"Ann Thorac Surg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-5223(97)70121-1","article-title":"Sternal resection for primary or secondary tumors","volume":"114","author":"M Incarbone","year":"1997","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757426.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:55Z","timestamp":1781176375000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/synchronous-whole-sternal-metastasis-from-primary-malignant-mediastinal-germ-cell-tumor-in-a-teenager\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":5,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,10,14]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757426","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]}}}