{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:49:13Z","timestamp":1779400153927,"version":"3.53.1"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebellar metastases represent the most common lesion requiring surgical treatment in the daily neurosurgical praxis. We report a rare case with Lhermitte\u2013Duclos disease presenting to the neurosurgical outpatient department and describe our diagnostic and treatment challenges. A 57-year-old man presented with transient cerebellar manifestations, including walking difficulties, dizziness, and a persistent occipital headache. The magnetic resonance imaging demonstrated a high-intensity lesion in the right cerebellar hemisphere on T2-weighted images. We initially considered surgery to establish a histopathological diagnosis. However, the magnetic resonance spectroscopy was compatible with a dysplastic gangliocytoma of the cerebellum. Therefore, we preferred a more conservative approach. Posterior fossa contrast-enhancing lesions are much more than metastases. The role of advanced magnetic resonance in avoiding unnecessary surgical interventions is priceless.<\/jats:p>","DOI":"10.1055\/s-0042-1757433","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T22:30:07Z","timestamp":1667082607000},"page":"680-682","source":"Crossref","is-referenced-by-count":1,"title":["Posterior Fossa Intra-Axial Lesion: There Are Pathologies Beyond Metastases"],"prefix":"10.1055","volume":"17","author":[{"given":"George","family":"Fotakopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros G.","family":"Brotis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Paterakis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Kapsalaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Thessaly, Medical School of Thessaly, Thessaly, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas N.","family":"Fountas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00005072-196910000-00005","article-title":"Lhermitte-Duclos disease (granule cell hypertrophy of the cerebellum) pathological analysis of the first familial cases","volume":"28","author":"M Ambler","year":"1969","journal-title":"J Neuropathol Exp Neurol"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","article-title":"Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System","volume":"22","author":"J S Barnholtz-Sloan","year":"2004","journal-title":"J Clin Oncol"},{"key":"ref3","first-page":"244","article-title":"Acute cerebellitis with tonsillar herniation: a case report","volume":"45","author":"G NM Coeli","year":"2012","journal-title":"Radiol Bras"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000455229","article-title":"MRI of cerebellar infarction","volume":"77","author":"L JL De Cocker","year":"2017","journal-title":"Eur Neurol"},{"issue":"13","key":"ref5","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.3390\/cancers13133120","article-title":"PTEN hamartoma tumor syndrome\/Cowden syndrome: genomics, oncogenesis, and imaging review for associated lesions and malignancy","volume":"13","author":"D D Dragoo","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.wneu.2015.12.066","article-title":"Posterior fossa intra-axial tumors in adults","volume":"88","author":"R Grossman","year":"2016","journal-title":"World Neurosurg"},{"issue":"05","key":"ref7","first-page":"824","article-title":"Lhermitte-Duclos Disease: Assessment with MR Imaging, Positron Emission Tomography, Single-photon Emission CT, and MR Spectroscopy","volume":"22","author":"J Klisch","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"ref8","first-page":"99","article-title":"On a diffuse ganglioneuroma of the cortex of the cerebellum","volume":"9","author":"J Lhermitte","year":"1920","journal-title":"Bull Assoc Franc Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-58-1-136","article-title":"Cowden's disease. 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