{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:42:55Z","timestamp":1792827775475,"version":"4.5.0"},"reference-count":84,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Haemonetics SA, Signy, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Viscoelastic testing (VET), such as thromboelastography, can measure whole blood coagulation dynamics in real time and is used across a range of clinical settings, including cardiac surgery, liver transplant, and trauma. The use of modified thromboelastography with platelet function assessment (TEG(R) PlateletMapping(R) Assay) can provide an analysis of platelet contribution to hemostasis, including the contribution of the P2Y12 receptor and thromboxane pathway to platelet function. The TEG PlateletMapping Assay has shown high correlation with the current gold standard test of platelet function, light transmission aggregometry, to measure arachidonic acid and adenosine diphosphate agonist-induced platelet activation. Studies have also shown comparable results with other whole blood platelet function tests. In this review, we explore the clinical applications of modified thromboelastography with platelet function assessment. This includes guiding dual antiplatelet therapy in relation to cardiac procedures, such as percutaneous coronary interventions, transcatheter aortic valve replacement, and left atrial appendage closure. We also explore the developing use of thromboelastography in the emergency care setting of coronavirus disease 2019, which is commonly associated with a hypercoagulable and hypofibrinolytic state. Despite a general lack of high-quality, grade 1 evidence regarding the use of modified thromboelastography with platelet function assessment in these disease areas, the ability of the TEG PlateletMapping Assay to measure global hemostasis and platelet reactivity rapidly and to view and evaluate results at the point of care makes it a promising area for further study for managing patient treatment and optimizing hemostatic therapy.<\/jats:p>","DOI":"10.1055\/s-0042-1757545","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T23:05:21Z","timestamp":1666047921000},"page":"192-200","source":"Crossref","is-referenced-by-count":16,"title":["Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review"],"prefix":"10.1055","volume":"49","author":[{"given":"Jan","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Haemonetics Corp., Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Southampton & Cardiothoracic Department, University Hospital Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"E118","DOI":"10.3390\/diagnostics10020118","article-title":"Viscoelastic hemostatic assays: moving from the laboratory to the site of care-a review of established and emerging technologies","volume":"10","author":"J Hartmann","year":"2020","journal-title":"Diagnostics (Basel)"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/ajh.26285","article-title":"Viscoelastic hemostatic assays: update on technology and clinical applications","volume":"96","author":"D Faraoni","year":"2021","journal-title":"Am J Hematol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/ALN.0000000000003814","article-title":"Viscoelastic coagulation testing: use and current limitations in perioperative decision-making","volume":"135","author":"G Erdoes","year":"2021","journal-title":"Anesthesiology"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/SLA.0000000000001608","article-title":"Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays","volume":"263","author":"E Gonzalez","year":"2016","journal-title":"Ann Surg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00134-020-06266-1","article-title":"Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled 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Lloyd-Donald","year":"2020","journal-title":"Sci Rep"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.lab.2004.01.011","article-title":"A novel modification of the thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation","volume":"143","author":"R M Craft","year":"2004","journal-title":"J Lab Clin Med"},{"issue":"08","key":"ref34","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00228-019-02687-0","article-title":"Half-dose ticagrelor versus high-dose clopidogrel in reducing platelet reactivity in acute coronary syndrome patients with high on-clopidogrel platelet reactivity (divide study)","volume":"75","author":"G Z Liu","year":"2019","journal-title":"Eur J Clin Pharmacol"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11239-019-01971-1","article-title":"Comparison of three common whole blood platelet function tests for in vitro 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Insights using short thrombelastography","volume":"111","author":"V Khanna","year":"2014","journal-title":"Thromb Haemost"},{"issue":"09","key":"ref38","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.jacc.2005.05.090","article-title":"Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation","volume":"46","author":"U S Tantry","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/jth.12909","article-title":"Does the response to aspirin and clopidogrel vary over 6 months in patients with ischemic heart disease?","volume":"13","author":"V Khanna","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.05.031","article-title":"\u201cAspirin resistance\u201d in ischemic stroke: insights using short thrombelastography","volume":"22","author":"N Sambu","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"20","key":"ref41","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1136\/heartjnl-2011-300192","article-title":"Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study","volume":"97","author":"N Sambu","year":"2011","journal-title":"Heart"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/14779072.2017.1266255","article-title":"Is arachidonic acid stimulation really a test for the response to aspirin? Time to think again?","volume":"15","author":"B Olechowski","year":"2017","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"06","key":"ref43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/09537100903003227","article-title":"Effects of clopidogrel on \u201caspirin specific\u201d pathways of platelet inhibition","volume":"20","author":"A R Hobson","year":"2009","journal-title":"Platelets"},{"issue":"04","key":"ref44","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5858\/arpa.2017-0556-CP","article-title":"External quality assurance of platelet function assays: results of the College of American Pathologists Proficiency Testing Program","volume":"143","author":"W L Chandler","year":"2019","journal-title":"Arch Pathol Lab Med"},{"issue":"08","key":"ref45","doi-asserted-by":"crossref","first-page":"914","DOI":"10.5858\/arpa.2019-0115-LE","article-title":"External quality assurance of platelet function assays: results of the College of American Pathologists Proficiency Testing Program","volume":"143","author":"J Hartmann","year":"2019","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1373\/clinchem.2014.226332","article-title":"Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy","volume":"60","author":"B S Karon","year":"2014","journal-title":"Clin Chem"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/00000542-200610000-00011","article-title":"Quantifying the effect of antiplatelet therapy: a comparison of the platelet function analyzer (PFA-100) and modified thromboelastography (mTEG) with light transmission platelet aggregometry","volume":"105","author":"S Agarwal","year":"2006","journal-title":"Anesthesiology"},{"issue":"02","key":"ref48","first-page":"404","article-title":"Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2)","volume":"102","author":"N Blais","year":"2009","journal-title":"Thromb Haemost"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1213\/ANE.0000000000004355","article-title":"Society of cardiovascular anesthesiologists clinical practice improvement advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients","volume":"129","author":"J Raphael","year":"2019","journal-title":"Anesth Analg"},{"issue":"24","key":"ref50","first-page":"e44","article-title":"2011 ACCF\/AHA\/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions","volume":"58","author":"G N Levine","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0140-6736(18)31858-0","article-title":"Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial","volume":"392","author":"P Vranckx","year":"2018","journal-title":"Lancet"},{"issue":"24","key":"ref52","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1001\/jama.2019.8146","article-title":"Effect of P2Y12 inhibitor monotherapy vs dual antiplatelet therapy on cardiovascular events in patients undergoing percutaneous coronary intervention: the SMART-CHOICE randomized clinical trial","volume":"321","author":"J-Y Hahn","year":"2019","journal-title":"JAMA"},{"issue":"24","key":"ref53","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1001\/jama.2019.8145","article-title":"Effect of 1-month dual antiplatelet therapy followed by clopidogrel vs 12-month dual antiplatelet therapy on cardiovascular and bleeding events in patients receiving PCI: the STOPDAPT-2 randomized clinical trial","volume":"321","author":"H Watanabe","year":"2019","journal-title":"JAMA"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2147\/VHRM.S6787","article-title":"Aspirin and clopidogrel hyporesponsiveness and nonresponsiveness in patients with coronary artery stenting","volume":"5","author":"R K Sharma","year":"2009","journal-title":"Vasc Health Risk Manag"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ahj.2010.05.034","article-title":"Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events","volume":"160","author":"P A Gurbel","year":"2010","journal-title":"Am Heart J"},{"issue":"09","key":"ref56","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/heartjnl-2011-301164","article-title":"Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry","volume":"98","author":"N Sambu","year":"2012","journal-title":"Heart"},{"issue":"21","key":"ref57","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1161\/CIRCULATIONAHA.117.030190","article-title":"Randomized comparisons of double-dose clopidogrel or adjunctive cilostazol versus standard dual antiplatelet in patients with high posttreatment platelet reactivity: results of the CREATIVE trial","volume":"137","author":"Y D Tang","year":"2018","journal-title":"Circulation"},{"key":"ref58","volume-title":"Clopidogrel therapy and CYP2C19 genotype","author":"L Dean","year":"2012"},{"issue":"13","key":"ref59","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.3390\/jcm11133652","article-title":"The use of thromboelastography in percutaneous coronary intervention and acute coronary syndrome in East Asia: a systematic literature review","volume":"11","author":"O Xu","year":"2022","journal-title":"J Clin Med"},{"issue":"06","key":"ref60","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jacc.2006.10.050","article-title":"Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?","volume":"49","author":"K P Bliden","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12959-022-00380-4","article-title":"Prediction of residual ischemic risk in ticagrelor-treated patients with acute coronary syndrome","volume":"20","author":"Y Zou","year":"2022","journal-title":"Thromb J"},{"issue":"03","key":"ref62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1755-5922.2010.00156.x","article-title":"Individualised assessment of response to clopidogrel in patients presenting with acute coronary syndromes: a role for short thrombelastography?","volume":"28","author":"J M Cotton","year":"2010","journal-title":"Cardiovasc Ther"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-9560-6-1","article-title":"Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with drug-eluting stent thrombosis whilst on dual antiplatelet therapy","volume":"6","author":"A R Hobson","year":"2008","journal-title":"Thromb J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2096181","DOI":"10.1155\/2016\/2096181","article-title":"Stent thrombosis patients with hyporesponsiveness to clopidogrel, prasugrel, and ticagrelor: a case series using short thromboelastography","volume":"2016","author":"B Olechowski","year":"2016","journal-title":"Case Rep Med"},{"issue":"02","key":"ref65","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jacc.2015.05.017","article-title":"2-Year outcomes in patients undergoing surgical or self-expanding transcatheter aortic valve replacement","volume":"66","author":"M J Reardon","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"e001565","DOI":"10.1136\/openhrt-2020-001565","article-title":"Evaluation of latest viscoelastic coagulation assays in the transcatheter aortic valve implantation setting","volume":"8","author":"J Fanning","year":"2021","journal-title":"Open Heart"},{"issue":"01","key":"ref67","first-page":"A11978","article-title":"Abstract 11978: increased early prothrombotic potential of transcatheter aortic valve implantation compared with percutaneous coronary intervention identified with viscoelastic hemostatic assessment of coagulation","volume":"144","author":"J P Fanning","year":"2021","journal-title":"Circulation"},{"issue":"02","key":"ref68","doi-asserted-by":"crossref","first-page":"418","DOI":"10.5603\/KP.a2017.0225","article-title":"Thromboelastography for predicting bleeding in patients with aortic stenosis treated with transcatheter aortic valve implantation","volume":"76","author":"B Rymuza","year":"2018","journal-title":"Kardiol Pol"},{"issue":"07","key":"ref69","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/17434440.2020.1781615","article-title":"The WATCHMAN left atrial appendage closure device for patients with atrial fibrillation: current status and future 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impact of blood transfusion on coronary artery bypass grafting outcomes","volume":"105","author":"T C Crawford","year":"2018","journal-title":"Ann Thorac Surg"},{"issue":"16","key":"ref73","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/CIRCULATIONAHA.116.023956","article-title":"Point-of-care hemostatic testing in cardiac surgery: a stepped-wedge clustered randomized controlled trial","volume":"134","author":"K Karkouti","year":"2016","journal-title":"Circulation"},{"issue":"07","key":"ref74","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/CIR.0b013e318256f1e0","article-title":"2012 ACCF\/AHA focused update of the guideline for the management of patients with unstable angina\/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"126","author":"H 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