{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:15Z","timestamp":1781179095169,"version":"3.54.1"},"reference-count":11,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Objectives\u2003This article reports the clinical outcomes of uterine body cancers in South Indian population. The primary outcome of our study was overall survival (OS). The secondary outcomes were disease-free survival (DFS), patterns of recurrence, toxicities of radiation treatment, and the association of patient, disease, and treatment characteristics with survival and recurrence.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003Records of the patients diagnosed as malignancy in uterus and treated with surgery alone or with adjuvant treatment from January 2013 to December 2017 were retrieved after Institute Ethics Committee approval. Demographic, surgical, histopathology, and adjuvant treatment details were retrieved. Patients of endometrial adenocarcinoma were stratified according to the European Society of Medical Oncology\/European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology consensus for analysis and overall outcomes irrespective of histology were also analyzed.<\/jats:p>\n                  <jats:p>Statistical Analysis\u2003For the survival analysis, Kaplan\u2013Meier survival estimator was used. Cox regression was used to test the significance of association of factors with outcomes in terms of hazard ratio (HR).<\/jats:p>\n                  <jats:p>Results\u2003A total of 178 patient records were retrieved. The median follow-up of all patients was 30 months (0.5\u201381 months). The median age of the population was 55 years. Most common histology was endometrioid type of adenocarcinoma (89%), sarcomas comprised only 4%. The mean OS of all patients was 68 months (n\u2009=\u2009178), median was not reached. Five-year OS was 79 %. Five-year OS rates observed in low, intermediate, high-intermediate, and high-risk were 91, 88, 75, and 81.5%, respectively. The mean DFS was 65 months, median not reached. The 5-year DFS was 76%. The 5-year DFS rates observed were 82, 95, 80, and 81.5% for low, intermediate, high-intermediate, and high-risk, respectively. Univariate analysis using Cox regression showed increase in hazard for death in case of node positivity, HR 3.96 (p 0.033). The HR for disease recurrence was 0.35 (p\u2009=\u20090.042) in patients who had received adjuvant radiation therapy. No other factors had any significant impact on death or disease recurrence.<\/jats:p>\n                  <jats:p>Conclusion\u2003The survival outcomes in terms of DFS and OS were comparable with other Indian and Western data reported in the published literature.<\/jats:p>","DOI":"10.1055\/s-0042-1757550","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T20:04:21Z","timestamp":1667419461000},"page":"087-092","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Uterine Body Cancers Treated in a Tertiary Cancer Center"],"prefix":"10.25259","volume":"12","author":[{"given":"K.","family":"Muthulingeshkumar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-5759","authenticated-orcid":false,"given":"Jagadesan","family":"Pandjatcharam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Chaturvedula","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up","volume":"27","author":"N Colombo","year":"2016","journal-title":"Ann Oncol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref3","first-page":"S105","article-title":"Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer","volume":"95","author":"W T Creasman","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","article-title":"Cancer statistics, 2006","volume":"56","author":"A Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/gyno.1994.1208","article-title":"Uterine papillary serous carcinoma: patterns of metastatic spread","volume":"54","author":"B A Goff","year":"1994","journal-title":"Gynecol Oncol"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/1097-0142(197809)42:3<1152::AID-CNCR2820420319>3.0.CO;2-L","article-title":"Uterine sarcomas: natural history, treatment and prognosis","volume":"42","author":"O M Salazar","year":"1978","journal-title":"Cancer"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1097\/IGC.0b013e3182a2ff46","article-title":"Clinical outcome of early-stage endometroid adenocarcinoma: a tertiary cancer center experience","volume":"23","author":"U Mahantshetty","year":"2013","journal-title":"Int J Gynecol Cancer"},{"issue":"05","key":"ref8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/IGC.0000000000001252","article-title":"Patterns of recurrence, long-term survival and toxicity analysis of endometrial adenocarcinoma patients reclassified under the recent ESMO-ESGO-ESTRO stratification: seven-year results from a single institution","volume":"28","author":"U P Kumar","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(09)62163-2","article-title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial","volume":"375","author":"R A Nout","year":"2010","journal-title":"Lancet"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"e631","DOI":"10.1016\/j.ijrobp.2011.04.013","article-title":"Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma","volume":"81","author":"C L Creutzberg","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1200\/JCO.2010.32.4590","article-title":"Long-term outcome and quality of life of patients with endometrial carcinoma treated with or without pelvic radiotherapy in the post operative radiation therapy in endometrial carcinoma 1 (PORTEC-1) trial","volume":"29","author":"R A Nout","year":"2011","journal-title":"J Clin Oncol"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757550.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:39Z","timestamp":1781176359000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/clinical-outcomes-of-uterine-body-cancers-treated-in-a-tertiary-cancer-center\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":11,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,2,25]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757550","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]}}}