{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:30Z","timestamp":1781179110108,"version":"3.54.1"},"reference-count":16,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary intraosseous synovial sarcoma (PISS) is a rare cancer of the bone, with few reported cases across literature. Data from our institute reveals seven indigenous cases. This study aims to evaluate these PISS diagnoses, and to further investigate any histopathological findings and prognostic factors associated with patient survival.<\/jats:p>\n                  <jats:p>Data from patients diagnosed with PISS at the institute were obtained from January 1995 to December 2016, in the form of a retrospective study. Patient demographics, pathology locations, histological findings, surgical margins, and treatment modalities were audited as variables that can impact patient survival.<\/jats:p>\n                  <jats:p>This research identified seven cases which fulfilled the diagnostic criteria and were subsequently classified as PISS of the bone. There were five men and two women among the cases, with ages ranging from 16 to 46 years, with a mean of 29.6 years. The study found that the lower limb was the most affected site in PISS, followed by the pelvis. Limb salvage was performed in six patients and one patient underwent amputation. Of these patients, six received adjuvant chemotherapy and four received adjuvant radiation as per institution guidelines. The study found that the 5-year disease-free and overall survival rate was 80 and 61%, respectively.<\/jats:p>\n                  <jats:p>PISS is a rare malignancy with limited cases in literature, and hence, there is no evidence for a standardized management protocol. The survival rates were similar between soft tissue and intraosseous synovial sarcoma among the case series.<\/jats:p>","DOI":"10.1055\/s-0042-1757551","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T19:28:06Z","timestamp":1691782086000},"page":"694-697","source":"Crossref","is-referenced-by-count":1,"title":["Primary Intraosseous Synovial Sarcoma: Experience from a Tertiary Cancer Center"],"prefix":"10.25259","volume":"14","author":[{"given":"Vishnu","family":"Ramanujan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Kumar","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-2431","authenticated-orcid":false,"given":"Kanuj","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-5816","authenticated-orcid":false,"given":"Venkatraman","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-8527","authenticated-orcid":false,"given":"Anand","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0140-6736(05)64278-X","article-title":"Synovial sarcoma of bone delineated by spectral karyotyping","volume":"350","author":"I J Cohen","year":"1997","journal-title":"Lancet"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5704\/MOJ.1203.003","article-title":"Intraosseous synovial sarcoma of the proximal femur: case report","volume":"6","author":"M Zulkarnaen","year":"2012","journal-title":"Malays Orthop J"},{"key":"ref3","first-page":"184891","article-title":"Intraosseous synovial sarcoma of the proximal tibia","volume":"2011","author":"S E Beck","year":"2011","journal-title":"Int J Surg Oncol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00256-006-0185-2","article-title":"Synovial sarcoma of primary bone origin: a rare case in a rare site with atypical features","volume":"36","author":"S C Jung","year":"2007","journal-title":"Skeletal Radiol"},{"issue":"07","key":"ref5","first-page":"95","article-title":"Primary synovial sarcoma of the distal femur: a rare case report","volume":"1","author":"X Wu","year":"2014","journal-title":"J Pain Manag"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00330-008-1292-3","article-title":"Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors","volume":"19","author":"M van Vliet","year":"2009","journal-title":"Eur Radiol"},{"issue":"09","key":"ref7","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1007\/s11999-008-0340-2","article-title":"Synovial sarcoma: from genetics to genetic-based animal modeling","volume":"466","author":"M Haldar","year":"2008","journal-title":"Clin Orthop Relat Res"},{"issue":"02","key":"ref8","first-page":"109","article-title":"Primary mediastinal synovial sarcoma","volume":"76","author":"R Jeganathan","year":"2007","journal-title":"Ulster Med J"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2106\/00004623-199904000-00014","article-title":"Histological and molecular evidence of synovial sarcoma of bone. A case report","volume":"81","author":"H Hiraga","year":"1999","journal-title":"J Bone Joint Surg Am"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00256-005-0006-z","article-title":"Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour\/Ewing sarcoma: differentiation by molecular genetic studies","volume":"35","author":"P O'Donnell","year":"2006","journal-title":"Skeletal Radiol"},{"key":"ref11","first-page":"5492754","article-title":"Primary intraosseous synovial sarcoma with molecular confirmation: expanding and clarifying the spectrum of this rare neoplasm","volume":"2020","author":"K E McHugh","year":"2020","journal-title":"Case Rep Pathol"},{"issue":"03","key":"ref12","first-page":"208","article-title":"Primary synovial sarcoma of the sternum: computed tomography and magnetic resonance imaging findings","volume":"23","author":"M Nakajo","year":"2005","journal-title":"Radiat Med"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00402-001-0356-5","article-title":"Surgical treatment of primary tumors of the sacrum","volume":"122","author":"C Sar","year":"2002","journal-title":"Arch Orthop Trauma Surg"},{"issue":"364","key":"ref14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00003086-199907000-00028","article-title":"Synovial sarcoma of the foot and ankle","author":"S P Scully","year":"1999","journal-title":"Clin Orthop Relat Res"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0714.2005.00375.x","article-title":"Synovial sarcoma of the mandible","volume":"35","author":"W M Tilakaratne","year":"2006","journal-title":"J Oral Pathol Med"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1445-1433.2004.03144.x","article-title":"Synovial sarcoma\u2013towards a simplified approach to prognosis","volume":"74","author":"C Campbell","year":"2004","journal-title":"ANZ J Surg"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:13:17Z","timestamp":1781176397000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/primary-intraosseous-synovial-sarcoma-experience-from-a-tertiary-cancer-center\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":16,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,12,29]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757551","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,11]]}}}