{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:51:39Z","timestamp":1793904699360,"version":"4.8.0"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003von Willebrand disease (VWD) is a genetic bleeding disorder caused by defects of von Willebrand factor (VWF), quantitative (type 1 and 3) or qualitative (type 2). The laboratory phenotyping is heterogenic making diagnosis difficult.<\/jats:p><jats:p>\n          Objectives\u2003Complete laboratory analysis of VWD as an expansion of the previously reported cross-sectional family-based VWD study in the Czech Republic (BRNO-VWD) and Slovakia (BRA-VWD) under the name \u201cHeart of Europe,\u201d in order to improve the understanding of laboratory phenotype\/genotype correlation.<\/jats:p><jats:p>\n          Patients and Methods\u2003In total, 227 suspected VWD patients were identified from historical records. Complete laboratory analysis was established using all available assays, including VWF multimers and genetic analysis.<\/jats:p><jats:p>\n          Results\u2003A total of 191 patients (from 119 families) were confirmed as having VWD. The majority was characterized as a type 1 VWD, followed by type 2. Multimeric patterns concordant with laboratory phenotypes were found in approximately 83% of all cases. A phenotype\/genotype correlation was present in 84% (77% type 1, 99% type 2, and 61% type 3) of all patients. Another 45 candidate mutations (23 novel variations), not found in the initial study, could be identified (missense 75% and truncating 24%). An exon 1\u20133 gene deletion was identified in 14 patients where no mutation was found by direct DNA sequencing, increasing the linkage up to 92%, overall.<\/jats:p><jats:p>\n          Conclusion\u2003This study provides a cross-sectional overview of the VWD population in a part of Central Europe. It is an addition to the previously published BRNO-VWD study, and provides important data to the International Society of Thrombosis and Haemostasis\/European Association for Haemophilia and Allied Disorders VWD mutation database with identification of novel causal mutations.<\/jats:p>","DOI":"10.1055\/s-0042-1757635","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T23:20:51Z","timestamp":1666221651000},"page":"e335-e346","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of von Willebrand Disease in the \u201cHeart of Europe\u201d"],"prefix":"10.1055","volume":"06","author":[{"given":"Inge","family":"Vangenechten","sequence":"additional","affiliation":[{"name":"Haemostasis Unit, Antwerp University Hospital, Edegem, Belgium"},{"name":"Medicine and Health Sciences, Haemostasis Research Unit, Antwerp University, Antwerp, Belgium"},{"name":"Antwerp University, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Smejkal","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic"},{"name":"Department of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Zavrelova","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic"},{"name":"Department of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Zapletal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology, University Hospital Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Haematology, University F. D. Roosevelt Hospital, Bansk\u00e1 Bystrica, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Jacques","family":"Michiels","sequence":"additional","affiliation":[{"name":"Blood Coagulation and Vascular Medicine Center, Goodheart Institute & Foundation in Nature Medicine, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zwi","family":"Berneman","sequence":"additional","affiliation":[{"name":"Antwerp University, Antwerp, Belgium"},{"name":"Department of Haematology, Antwerp University Hospital, Edegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Blatny","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology, University Hospital Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Batorova","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Department of Haematology and Blood Transfusion of the Medical School of the Comenius University, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Prigancova","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Department of Haematology and Blood Transfusion of the Medical School of the Comenius University, Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Penka","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic"},{"name":"Department of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Gadisseur","sequence":"additional","affiliation":[{"name":"Haemostasis Unit, Antwerp University Hospital, Edegem, Belgium"},{"name":"Medicine and Health Sciences, Haemostasis Research Unit, Antwerp University, Antwerp, Belgium"},{"name":"Antwerp University, Antwerp, Belgium"},{"name":"Department of Haematology, Antwerp University Hospital, Edegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand's disease","volume":"69","author":"F Rodeghiero","year":"1987","journal-title":"Blood"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2012-01-405134","article-title":"Sequence and structure relationships within von Willebrand factor","volume":"120","author":"Y F Zhou","year":"2012","journal-title":"Blood"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0049-3848(77)90196-7","article-title":"Interaction of collagen with the factor VIII antigen-activity - von Willebrand factor complex","volume":"11","author":"D Nyman","year":"1977","journal-title":"Thromb Res"},{"issue":"40","key":"ref4","doi-asserted-by":"crossref","first-page":"23352","DOI":"10.1074\/jbc.270.40.23352","article-title":"Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets","volume":"270","author":"S Goto","year":"1995","journal-title":"J Biol Chem"},{"issue":"15","key":"ref5","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1073\/pnas.81.15.4935","article-title":"ADP-dependent common receptor mechanism for binding of von Willebrand factor and fibrinogen to human platelets","volume":"81","author":"S Timmons","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor","volume":"4","author":"J E Sadler","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1182\/blood-2014-08-551960","article-title":"How I treat type 2 variant forms of von Willebrand disease","volume":"125","author":"A Tosetto","year":"2015","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1538-7836.2011.04324.x","article-title":"von Willebrand factor: the complex molecular genetics of a multidomain and multifunctional protein","volume":"9","author":"R Schneppenheim","year":"2011","journal-title":"J Thromb Haemost"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.thromres.2007.03.014","article-title":"Von Willebrand disease - phenotype versus genotype: deficiency versus disease","volume":"120","author":"D Lillicrap","year":"2007","journal-title":"Thromb Res"},{"issue":"19","key":"ref10","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1182\/blood-2011-06-360875","article-title":"Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage","volume":"119","author":"P M Jacobi","year":"2012","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0049-3848(09)70150-1","article-title":"Classification of inherited von Willebrand disease and implications in clinical practice","volume":"124","author":"A B Federici","year":"2009","journal-title":"Thromb Res"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2010.03.003","article-title":"The genetic basis of von Willebrand disease","volume":"24","author":"A C Goodeve","year":"2010","journal-title":"Blood Rev"},{"issue":"13","key":"ref13","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1182\/blood-2014-08-528398","article-title":"Diagnostic approach to von Willebrand disease","volume":"125","author":"C Ng","year":"2015","journal-title":"Blood"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/jth.14145","article-title":"A comparative analysis of different automated von Willebrand factor glycoprotein Ib-binding activity assays in well typed von Willebrand disease patients","volume":"16","author":"I Vangenechten","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1182\/blood-2006-05-020784","article-title":"Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)","volume":"109","author":"A Goodeve","year":"2007","journal-title":"Blood"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"e3038","DOI":"10.1097\/MD.0000000000003038","article-title":"A laboratory phenotype\/genotype correlation of 1167 French patients from 670 families with von willebrand disease: a new epidemiologic picture","volume":"95","author":"A Veyradier","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1182\/blood-2006-05-021105","article-title":"The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study","volume":"109","author":"P D James","year":"2007","journal-title":"Blood"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1055\/s-0039-1678528","article-title":"Analysis of von Willebrand disease in the South Moravian population (Czech Republic): results from the BRNO-VWD study","volume":"119","author":"I Vangenechten","year":"2019","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1111\/hae.13261","article-title":"Evaluation of a new commercial von Willebrand factor multimer assay","volume":"23","author":"E J Favaloro","year":"2017","journal-title":"Haemophilia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-1-4939-7196-1_36","article-title":"Laboratory testing for Von Willebrand factor multimers","volume":"1646","author":"S Oliver","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/rth2.12141","article-title":"Evaluation of a semi-automated von Willebrand factor multimer assay, the Hydragel 5 von Willebrand multimer, by two European centers","volume":"2","author":"A E Bowyer","year":"2018","journal-title":"Res Pract Thromb Haemost"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/ijlh.12869","article-title":"Evaluation of a new commercial method for von Willebrand factor multimeric analysis","volume":"40","author":"R A Crist","year":"2018","journal-title":"Int J Lab Hematol"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"e22416","DOI":"10.1002\/jcla.22416","article-title":"Preclinical evaluation of a semi-automated and rapid commercial electrophoresis assay for von Willebrand factor multimers","volume":"32","author":"M Pikta","year":"2018","journal-title":"J Clin Lab Anal"},{"issue":"06","key":"ref24","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/ijlh.13107","article-title":"Semi-automated von Willebrand factor multimer assay for von Willebrand disease: further validation, benefits and limitations","volume":"41","author":"S Oliver","year":"2019","journal-title":"Int J Lab Hematol"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/rth2.12408","article-title":"Improving diagnosis of von Willebrand disease: reference ranges for von Willebrand factor multimer distribution","volume":"4","author":"I Vangenechten","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"W201","DOI":"10.1093\/nar\/gkx390","article-title":"DEOGEN2: prediction and interactive visualization of single amino acid variant deleteriousness in human proteins","volume":"45","author":"D Raimondi","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"ref27","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1093\/nar\/gkf493","article-title":"Human non-synonymous SNPs: server and survey","volume":"30","author":"V Ramensky","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"I A Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"ref29","first-page":"20","article-title":"Predicting functional effect of human missense mutations using PolyPhen-2","volume":"Chapter 7","author":"I Adzhubei","year":"2013","journal-title":"Curr Protoc Hum Genet"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmeth.2890","article-title":"MutationTaster2: mutation prediction for the deep-sequencing age","volume":"11","author":"J M Schwarz","year":"2014","journal-title":"Nat Methods"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"P D James","year":"2021","journal-title":"Blood Adv"},{"issue":"23","key":"ref32","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1182\/blood-2009-07-226324","article-title":"A cluster of mutations in the D3 domain of von Willebrand factor correlates with a distinct subgroup of von Willebrand disease: type 2A\/IIE","volume":"115","author":"R Schneppenheim","year":"2010","journal-title":"Blood"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1053\/beha.2001.0134","article-title":"A molecular approach to the classification of von Willebrand disease","volume":"14","author":"R Schneppenheim","year":"2001","journal-title":"Best Pract Res Clin Haematol"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/j.seminhematol.2004.10.002","article-title":"Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update","volume":"42","author":"R Schneppenheim","year":"2005","journal-title":"Semin Hematol"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/1076029606293422","article-title":"Classification and characterization of hereditary types 2A, 2B, 2C, 2D, 2E, 2M, 2N, and 2U (unclassifiable) von Willebrand disease","volume":"12","author":"J J Michiels","year":"2006","journal-title":"Clin Appl Thromb Hemost"},{"issue":"06","key":"ref36","doi-asserted-by":"crossref","first-page":"e0179566","DOI":"10.1371\/journal.pone.0179566","article-title":"Type 2B von Willebrand disease with or without large multimers: a distinction of the two sides of the disorder is long overdue","volume":"12","author":"A Casonato","year":"2017","journal-title":"PLoS One"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood.V68.1.149.149","article-title":"A new von Willebrand variant (type I, New York): increased ristocetin-induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers","volume":"68","author":"H J Weiss","year":"1986","journal-title":"Blood"},{"issue":"05","key":"ref38","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1172\/JCI116443","article-title":"von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure","volume":"91","author":"L Holmberg","year":"1993","journal-title":"J Clin Invest"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/beha.2001.0137","article-title":"Type 2 von Willebrand disease causing defective von Willebrand factor-dependent platelet function","volume":"14","author":"D Meyer","year":"2001","journal-title":"Best Pract Res Clin Haematol"},{"issue":"20","key":"ref40","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1073\/pnas.89.20.9846","article-title":"von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib","volume":"89","author":"I Rabinowitz","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"03","key":"ref41","first-page":"848","article-title":"Ser968Thr mutation within the A3 domain of von Willebrand factor (VWF) in two related patients leads to a defective binding of VWF to collagen","volume":"86","author":"A S Ribba","year":"2001","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref42","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/j.1538-7836.2010.03869.x","article-title":"Absent collagen binding in a VWF A3 domain mutant: utility of the VWF:CB in diagnosis of VWD","volume":"8","author":"V H Flood","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2012.04661.x","article-title":"Different bleeding risk in type 2A and 2M von Willebrand disease: a 2-year prospective study in 107 patients","volume":"10","author":"G Castaman","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1055\/s-0036-1579641","article-title":"Type 2M and Type 2A von Willebrand disease: similar but different","volume":"42","author":"E J Favaloro","year":"2016","journal-title":"Semin Thromb Hemost"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/s-0031-1281037","article-title":"Management of inherited von Willebrand disease in Italy: results from the retrospective study on 1234 patients","volume":"37","author":"A B Federici","year":"2011","journal-title":"Semin Thromb Hemost"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/j.1538-7836.2008.03107.x","article-title":"An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary","volume":"6","author":"A Mohl","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1538-7836.2006.01823.x","article-title":"Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD","volume":"4","author":"J Eikenboom","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"20","key":"ref48","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1182\/blood-2015-10-673681","article-title":"Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States","volume":"127","author":"V H Flood","year":"2016","journal-title":"Blood"},{"issue":"05","key":"ref49","first-page":"630","article-title":"An investigation of the von Willebrand factor genotype in UK patients diagnosed to have type 1 von Willebrand disease","volume":"96","author":"A Cumming","year":"2006","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1160\/TH12-02-0089","article-title":"Mutation distribution in the von Willebrand factor gene related to the different von Willebrand disease (VWD) types in a cohort of VWD patients","volume":"108","author":"H Yadegari","year":"2012","journal-title":"Thromb Haemost"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/CIRCULATIONAHA.109.869156","article-title":"Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: the CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) consortium","volume":"121","author":"N L Smith","year":"2010","journal-title":"Circulation"},{"issue":"07","key":"ref52","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/ejhg.2016.21","article-title":"Genome-wide association studies identify genetic loci for low von Willebrand factor levels","volume":"24","author":"J van Loon","year":"2016","journal-title":"Eur J Hum Genet"}],"container-title":["TH Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T23:22:30Z","timestamp":1666221750000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1757635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":52,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,10,7]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757635","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}