{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:11Z","timestamp":1787004911887,"version":"build-2736575974"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Compared with conventional coagulation tests and factor-specific assays, viscoelastic hemostatic assays (VHAs) can provide a more thorough evaluation of clot formation and lysis but have several limitations including clot deformation. In this proof-of-concept study, we test a noncontact technique, termed resonant acoustic rheometry (RAR), for measuring the kinetics of human plasma coagulation. Specifically, RAR utilizes a dual-mode ultrasound technique to induce and detect surface oscillation of blood samples without direct physical contact and measures the resonant frequency of the surface oscillation over time, which is reflective of the viscoelasticity of the sample. Analysis of RAR results of normal plasma allowed defining a set of parameters for quantifying coagulation. RAR detected a flat-line tracing of resonant frequency in hemophilia A plasma that was corrected with the addition of tissue factor. Our RAR results captured the kinetics of plasma coagulation and the newly defined RAR parameters correlated with increasing tissue factor concentration in both healthy and hemophilia A plasma. These findings demonstrate the feasibility of RAR as a novel approach for VHA, providing the foundation for future studies to compare RAR parameters to conventional coagulation tests, factor-specific assays, and VHA parameters.<\/jats:p>","DOI":"10.1055\/s-0042-1757896","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T19:58:05Z","timestamp":1667332685000},"page":"201-208","source":"Crossref","is-referenced-by-count":10,"title":["Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method"],"prefix":"10.1055","volume":"49","author":[{"given":"Weiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor M.","family":"Bunch","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Internal Medicine, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Internal Medicine, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Nehme","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Internal Medicine, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hau C.","family":"Kwaan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, St. Joseph Regional Medical Center, Mishawaka, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"McCurdy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Aversa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony V.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine South Bend Campus, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuha","family":"Zackariya","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine South Bend Campus, Notre Dame, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, St. Joseph Regional Medical Center, Mishawaka, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Michigan Medicine, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard C.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henry Ford Hospital, Detroit, 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