{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:27Z","timestamp":1787169747639,"version":"build-2736575974"},"reference-count":202,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Headache disorders can produce recurrent, incapacitating pain. Migraine and cluster headache are notable for their ability to produce significant disability. The anatomy and physiology of headache disorders is fundamental to evolving treatment approaches and research priorities. Key concepts in headache mechanisms include activation and sensitization of trigeminovascular, brainstem, thalamic, and hypothalamic neurons; modulation of cortical brain regions; and activation of descending pain circuits. This review will examine the relevant anatomy of the trigeminal, brainstem, subcortical, and cortical brain regions and concepts related to the pathophysiology of migraine and cluster headache disorders.<\/jats:p>","DOI":"10.1055\/s-0042-1757924","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T19:37:37Z","timestamp":1667417857000},"page":"459-473","source":"Crossref","is-referenced-by-count":9,"title":["Anatomy and Physiology of Headache"],"prefix":"10.1055","volume":"42","author":[{"given":"Andrea M.","family":"Harriott","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Orlova","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1212\/01.wnl.0000252808.97649.21","article-title":"Migraine prevalence, disease burden, and the need for preventive therapy","volume":"68","author":"R B Lipton","year":"2007","journal-title":"Neurology"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"GBD 2016 Headache Collaborators","year":"2018","journal-title":"Lancet Neurol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache: a documentation of headache prevalence and disability worldwide","volume":"27","author":"Lj Stovner","year":"2007","journal-title":"Cephalalgia"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11916-003-0025-1","article-title":"Epidemiology of cluster headache","volume":"7","author":"A G Finkel","year":"2003","journal-title":"Curr Pain Headache Rep"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archsurg.1940.01210040002001","article-title":"Experimental studies on headache: pain-sensitive structures of the head and their significance in headache","volume":"41","author":"B Ray","year":"1940","journal-title":"Arch Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/384560a0","article-title":"Sensitization of meningeal sensory neurons and the origin of headaches","volume":"384","author":"A M Strassman","year":"1996","journal-title":"Nature"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1152\/jn.00029.2002","article-title":"Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura","volume":"88","author":"D Levy","year":"2002","journal-title":"J Neurophysiol"},{"issue":"S 01","key":"ref8","first-page":"1","article-title":"Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain","volume":"154","author":"R Noseda","year":"2013","journal-title":"Pain"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1468-2982.2002.00358.x","article-title":"Unilateral cranial autonomic symptoms in migraine","volume":"22","author":"P Barbanti","year":"2002","journal-title":"Cephalalgia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/brain\/111.5.1199","article-title":"Autonomic disturbances in cluster headache","volume":"111","author":"P D Drummond","year":"1988","journal-title":"Brain"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0306-4522(86)90293-9","article-title":"Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat","volume":"19","author":"M A Arbab","year":"1986","journal-title":"Neuroscience"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0361-9230(85)90181-9","article-title":"Innervation of the posterior fossa dura of the cat","volume":"14","author":"J T Keller","year":"1985","journal-title":"Brain Res Bull"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1523\/JNEUROSCI.2153-18.2018","article-title":"Non-trigeminal nociceptive innervation of the posterior dura: implications to occipital headache","volume":"39","author":"R Noseda","year":"2019","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2008.02.078","article-title":"Central projections of the sensory innervation of the rat middle meningeal artery","volume":"1208","author":"Y Liu","year":"2008","journal-title":"Brain Res"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cne.22049","article-title":"Sensory innervation of the calvarial bones of the mouse","volume":"515","author":"B Kosaras","year":"2009","journal-title":"J Comp Neurol"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.pain.2014.04.019","article-title":"The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior","volume":"155","author":"J Zhao","year":"2014","journal-title":"Pain"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.pain.2013.04.040","article-title":"Extracranial projections of meningeal afferents and their impact on meningeal nociception and headache","volume":"154","author":"M Schueler","year":"2013","journal-title":"Pain"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02116853","article-title":"Microvascularization of the intracranial dura mater","volume":"9","author":"J Roland","year":"1987","journal-title":"Surg Radiol Anat"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3174\/ajnr.A6739","article-title":"Middle meningeal artery: anatomy and variations","volume":"41","author":"S Bonasia","year":"2020","journal-title":"AJNR Am J Neuroradiol"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00702-020-02161-7","article-title":"Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators","volume":"127","author":"K Messlinger","year":"2020","journal-title":"J Neural Transm (Vienna)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.npep.2015.03.006","article-title":"Migraine and neuropeptides","volume":"52","author":"J Tajti","year":"2015","journal-title":"Neuropeptides"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0301-0082(01)00021-1","article-title":"Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus","volume":"66","author":"N E Lazarov","year":"2002","journal-title":"Prog Neurobiol"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1038\/s41598-022-09325-3","article-title":"Distribution and possible function of galanin about headache and immune system in the rat dura mater","volume":"12","author":"K Shimazaki","year":"2022","journal-title":"Sci Rep"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00001756-199401120-00024","article-title":"Enkephalins occur and colocalize with substance P in human trigeminal ganglion neurones","volume":"5","author":"M Quartu","year":"1994","journal-title":"Neuroreport"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.regpep.2009.02.002","article-title":"Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia","volume":"154","author":"H Imboden","year":"2009","journal-title":"Regul Pept"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2018.06.007","article-title":"Characterization of dural afferent neurons innervating cranial blood vessels within the dura in rats","volume":"1696","author":"M Nakamura","year":"2018","journal-title":"Brain Res"},{"issue":"44","key":"ref27","doi-asserted-by":"crossref","first-page":"15439","DOI":"10.1523\/JNEUROSCI.3265-12.2012","article-title":"Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT(1B\/D) agonist","volume":"32","author":"E A Kaiser","year":"2012","journal-title":"J Neurosci"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2009.07.009","article-title":"Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP","volume":"58","author":"A Recober","year":"2010","journal-title":"Neuropharmacology"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1523\/JNEUROSCI.2967-16.2016","article-title":"Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms","volume":"37","author":"B N Mason","year":"2017","journal-title":"J Neurosci"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-019-0968-1","article-title":"Migraine-provoking substances evoke periorbital allodynia in mice","volume":"20","author":"F De Logu","year":"2019","journal-title":"J Headache Pain"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1097\/j.pain.0000000000001337","article-title":"Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine","volume":"159","author":"B J Rea","year":"2018","journal-title":"Pain"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","article-title":"CGRP may play a causative role in migraine","volume":"22","author":"L H Lassen","year":"2002","journal-title":"Cephalalgia"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/jamaneurol.2018.1675","article-title":"Effect of infusion of calcitonin gene-related peptide on cluster headache attacks: a randomized clinical trial","volume":"75","author":"A LH Vollesen","year":"2018","journal-title":"JAMA Neurol"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ana.410280213","article-title":"Vasoactive peptide release in the extracerebral circulation of humans during migraine headache","volume":"28","author":"P J Goadsby","year":"1990","journal-title":"Ann Neurol"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1468-29821995.1505384.x","article-title":"Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally","volume":"15","author":"V Gallai","year":"1995","journal-title":"Cephalalgia"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1046\/j.1468-2982.2000.00146.x","article-title":"Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks","volume":"20","author":"P Sarchielli","year":"2000","journal-title":"Cephalalgia"},{"issue":"03","key":"ref37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00188214","article-title":"Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity","volume":"188","author":"K Messlinger","year":"1993","journal-title":"Anat Embryol (Berl)"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s10194-018-0852-4","article-title":"PACAP and its role in primary headaches","volume":"19","author":"L Edvinsson","year":"2018","journal-title":"J Headache Pain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/brain\/awt369","article-title":"Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38","volume":"137","author":"F M Amin","year":"2014","journal-title":"Brain"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"e2118543","DOI":"10.1001\/jamanetworkopen.2021.18543","article-title":"Effect of vasoactive intestinal polypeptide on development of migraine headaches: a randomized clinical trial","volume":"4","author":"L Pellesi","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s10194-018-0850-6","article-title":"PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma","volume":"19","author":"J A Waschek","year":"2018","journal-title":"J Headache Pain"},{"issue":"21","key":"ref42","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1111\/bph.14053","article-title":"Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine","volume":"175","author":"T Sundrum","year":"2018","journal-title":"Br J Pharmacol"},{"issue":"03","key":"ref43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jemt.1086","article-title":"Origin and co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat","volume":"53","author":"L Edvinsson","year":"2001","journal-title":"Microsc Res Tech"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/brain\/123.9.1830","article-title":"Nitric oxide-induced headache in patients with chronic tension-type headache","volume":"123","author":"M Ashina","year":"2000","journal-title":"Brain"},{"issue":"02","key":"ref45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1468-2982.2004.00634.x","article-title":"Periods of cluster headache induced by nitrate therapy and spontaneous remission of angina pectoris during active clusters","volume":"24","author":"K Ekbom","year":"2004","journal-title":"Cephalalgia"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","article-title":"Characterization of a novel model of chronic migraine","volume":"155","author":"A A Pradhan","year":"2014","journal-title":"Pain"},{"issue":"10","key":"ref47","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nm.2216","article-title":"A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura","volume":"16","author":"R G Lafreni\u00e8re","year":"2010","journal-title":"Nat Med"},{"issue":"31","key":"ref48","doi-asserted-by":"crossref","first-page":"12810","DOI":"10.1523\/JNEUROSCI.1237-13.2013","article-title":"Functional analysis of a migraine-associated TRESK K+ channel mutation","volume":"33","author":"P Liu","year":"2013","journal-title":"J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/srep00237","article-title":"Functional analysis of missense variants in the TRESK (KCNK18) K channel","volume":"2","author":"I Andres-Enguix","year":"2012","journal-title":"Sci Rep"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neuroscience.2010.02.063","article-title":"Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino-neuronal pathway","volume":"167","author":"H Wulf-Johansson","year":"2010","journal-title":"Neuroscience"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1097\/j.pain.0000000000002238","article-title":"Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine","volume":"162","author":"M A Al-Karagholi","year":"2021","journal-title":"Pain"},{"issue":"09","key":"ref52","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/brain\/awz199","article-title":"Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine","volume":"142","author":"M A Al-Karagholi","year":"2019","journal-title":"Brain"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"652136","DOI":"10.3389\/fphys.2021.652136","article-title":"The effect of K ATP channel blocker glibenclamide on CGRP-induced headache and hemodynamic in healthy volunteers","volume":"12","author":"H Coskun","year":"2021","journal-title":"Front Physiol"},{"issue":"23","key":"ref54","doi-asserted-by":"crossref","first-page":"7878","DOI":"10.1523\/JNEUROSCI.6053-09.2010","article-title":"Ionic mechanisms underlying inflammatory mediator-induced sensitization of dural afferents","volume":"30","author":"A H Vaughn","year":"2010","journal-title":"J Neurosci"},{"issue":"18","key":"ref55","doi-asserted-by":"crossref","first-page":"17678","DOI":"10.1074\/jbc.M501110200","article-title":"Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma","volume":"280","author":"A Tottene","year":"2005","journal-title":"J Biol Chem"},{"issue":"07","key":"ref56","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.bbamem.2012.11.012","article-title":"Calcium channels and migraine","volume":"1828","author":"D Pietrobon","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"06","key":"ref57","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1152\/jn.00551.2011","article-title":"Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons","volume":"107","author":"J Tao","year":"2012","journal-title":"J Neurophysiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuroscience.2010.10.032","article-title":"Role for voltage gated calcium channels in calcitonin gene-related peptide release in the rat trigeminovascular system","volume":"172","author":"D V Amrutkar","year":"2011","journal-title":"Neuroscience"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1744-8069-4-12","article-title":"Release of glutamate and CGRP from trigeminal ganglion neurons: role of calcium channels and 5-HT1 receptor signaling","volume":"4","author":"Y Xiao","year":"2008","journal-title":"Mol Pain"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuroscience.2004.08.054","article-title":"Calcium channels modulate nociceptive transmission in the trigeminal nucleus of the cat","volume":"135","author":"K G Shields","year":"2005","journal-title":"Neuroscience"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s13311-018-0619-2","article-title":"Targeted acid-sensing ion channel therapies for migraine","volume":"15","author":"N Karsan","year":"2018","journal-title":"Neurotherapeutics"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pain.2010.09.036","article-title":"Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache","volume":"152","author":"J Yan","year":"2011","journal-title":"Pain"},{"issue":"17","key":"ref63","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: multiple processes, complex pathophysiology","volume":"35","author":"R Burstein","year":"2015","journal-title":"J Neurosci"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuropharm.2019.02.015","article-title":"Mechanosensitive meningeal nociception via Piezo channels: implications for pulsatile pain in migraine?","volume":"149","author":"N Mikhailov","year":"2019","journal-title":"Neuropharmacology"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/0333102416637832","article-title":"Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura","volume":"37","author":"L A McIlvried","year":"2017","journal-title":"Cephalalgia"},{"issue":"03","key":"ref66","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/ana.25169","article-title":"Activation of pial and dural macrophages and dendritic cells by cortical spreading depression","volume":"83","author":"A J Schain","year":"2018","journal-title":"Ann Neurol"},{"issue":"03","key":"ref67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.brainresrev.2004.09.001","article-title":"Satellite glial cells in sensory ganglia: from form to function","volume":"48","author":"M Hanani","year":"2005","journal-title":"Brain Res Brain Res Rev"},{"issue":"04","key":"ref68","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/10799893.2014.885049","article-title":"Investigating the expression of metabotropic glutamate receptors in trigeminal ganglion neurons and satellite glial cells: implications for craniofacial pain","volume":"34","author":"D Boye Larsen","year":"2014","journal-title":"J Recept Signal Transduct Res"},{"issue":"03","key":"ref69","doi-asserted-by":"crossref","first-page":"E711","DOI":"10.3390\/ijms20030711","article-title":"CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception","volume":"20","author":"S Afroz","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2007.12.028","article-title":"Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells","volume":"1196","author":"J Li","year":"2008","journal-title":"Brain Res"},{"issue":"11","key":"ref71","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.neuron.2022.03.003","article-title":"Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine","volume":"110","author":"L Yang","year":"2022","journal-title":"Neuron"},{"issue":"02","key":"ref72","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1152\/jn.1988.59.2.648","article-title":"Responses of feline trigeminal spinal tract nucleus neurons to stimulation of the middle meningeal artery and sagittal sinus","volume":"59","author":"K D Davis","year":"1988","journal-title":"J Neurophysiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1469-7580.1999.19440579.x","article-title":"Stimulation of the middle meningeal artery leads to Fos expression in the trigeminocervical nucleus: a comparative study of monkey and cat","volume":"194","author":"K L Hoskin","year":"1999","journal-title":"J Anat"},{"issue":"06","key":"ref74","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1523\/JNEUROSCI.14-06-03725.1994","article-title":"Distribution of fos-like immunoreactivity in the medullary and upper cervical dorsal horn produced by stimulation of dural blood vessels in the rat","volume":"14","author":"A M Strassman","year":"1994","journal-title":"J Neurosci"},{"issue":"01","key":"ref75","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-8993(93)90486-7","article-title":"Expression of c-Fos-like immunoreactivity in the caudal medulla and upper cervical spinal cord following stimulation of the superior sagittal sinus in the cat","volume":"629","author":"H Kaube","year":"1993","journal-title":"Brain Res"},{"issue":"02","key":"ref76","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0006-8993(69)90114-0","article-title":"Convergence of visceral and cutaneous afferent pathways in the lumbar spinal cord","volume":"14","author":"M Selzer","year":"1969","journal-title":"Brain Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1093\/brain\/awf166","article-title":"Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input","volume":"125","author":"T Bartsch","year":"2002","journal-title":"Brain"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1212\/WNL.64.10_suppl_2.S9","article-title":"Migraine as an inflammatory disorder","volume":"64","author":"C Waeber","year":"2005","journal-title":"Neurology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0140-6736(79)92692-8","article-title":"Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine?","volume":"2","author":"M A Moskowitz","year":"1979","journal-title":"Lancet"},{"issue":"08","key":"ref80","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","article-title":"Does inflammation have a role in migraine?","volume":"15","author":"L Edvinsson","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"03","key":"ref81","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1468-2982.1997.1703166.x","article-title":"Release of histamine from dural mast cells by substance P and calcitonin gene-related peptide","volume":"17","author":"A Ottosson","year":"1997","journal-title":"Cephalalgia"},{"issue":"02","key":"ref82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1468-2982.1988.0802083.x","article-title":"Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular headache","volume":"8","author":"S Markowitz","year":"1988","journal-title":"Cephalalgia"},{"issue":"03","key":"ref83","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0306-4522(98)00366-2","article-title":"Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro","volume":"89","author":"A Ebersberger","year":"1999","journal-title":"Neuroscience"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-2999(94)90541-X","article-title":"Investigation of the role of tachykinin NK1, NK2 receptors and CGRP receptors in neurogenic plasma protein extravasation in dura mater","volume":"263","author":"C T O'Shaughnessy","year":"1994","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"ref85","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1523\/JNEUROSCI.07-12-04129.1987","article-title":"Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain","volume":"7","author":"S Markowitz","year":"1987","journal-title":"J Neurosci"},{"issue":"03","key":"ref86","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1476-5381.1994.tb13168.x","article-title":"Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva","volume":"112","author":"W S Lee","year":"1994","journal-title":"Br J Pharmacol"},{"issue":"07","key":"ref87","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1468-2982.1997.1707785.x","article-title":"Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study","volume":"17","author":"D J Goldstein","year":"1997","journal-title":"Cephalalgia"},{"issue":"02","key":"ref88","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/1531-8249(200002)47:2<238::AID-ANA15>3.0.CO;2-L","article-title":"No acute antimigraine efficacy of CP-122,288, a highly potent inhibitor of neurogenic inflammation: results of two randomized, double-blind, placebo-controlled clinical trials","volume":"47","author":"K I Roon","year":"2000","journal-title":"Ann Neurol"},{"issue":"01","key":"ref89","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.410330109","article-title":"The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats","volume":"33","author":"P J Goadsby","year":"1993","journal-title":"Ann Neurol"},{"issue":"10","key":"ref90","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1526-4610.2004.04189.x","article-title":"Chemokine levels in the jugular venous blood of migraine without aura patients during attacks","volume":"44","author":"P Sarchielli","year":"2004","journal-title":"Headache"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pain.2007.03.012","article-title":"Mast cell degranulation activates a pain pathway underlying migraine headache","volume":"130","author":"D Levy","year":"2007","journal-title":"Pain"},{"issue":"01","key":"ref92","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pain.2010.10.002","article-title":"Tumor necrosis factor-\u03b1 induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions","volume":"152","author":"X C Zhang","year":"2011","journal-title":"Pain"},{"issue":"01","key":"ref93","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/0333102411430848","article-title":"Local action of the proinflammatory cytokines IL-1\u03b2 and IL-6 on intracranial meningeal nociceptors","volume":"32","author":"X Zhang","year":"2012","journal-title":"Cephalalgia"},{"issue":"13","key":"ref94","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1177\/0333102413486320","article-title":"A chronic animal model of migraine, induced by repeated meningeal nociception, characterized by a behavioral and pharmacological approach","volume":"33","author":"A Melo-Carrillo","year":"2013","journal-title":"Cephalalgia"},{"issue":"02","key":"ref95","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1152\/jn.1998.79.2.964","article-title":"Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons","volume":"79","author":"R Burstein","year":"1998","journal-title":"J Neurophysiol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(98)00051-7","article-title":"The NMDA receptor antagonist MK-801 reduces capsaicin-induced c-fos expression within rat trigeminal nucleus caudalis","volume":"76","author":"D D Mitsikostas","year":"1998","journal-title":"Pain"},{"issue":"03","key":"ref97","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.j.pain.0000460325.25762.c0","article-title":"Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors","volume":"156","author":"A P Andreou","year":"2015","journal-title":"Pain"},{"issue":"08","key":"ref98","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1468-2982.2008.01588.x","article-title":"Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat","volume":"28","author":"R Noseda","year":"2008","journal-title":"Cephalalgia"},{"issue":"42","key":"ref99","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1523\/JNEUROSCI.1162-19.2019","article-title":"Parabrachial complex: a hub for pain and aversion","volume":"39","author":"M C Chiang","year":"2019","journal-title":"J Neurosci"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nature25511","article-title":"Encoding of danger by parabrachial CGRP neurons","volume":"555","author":"C A Campos","year":"2018","journal-title":"Nature"},{"issue":"17","key":"ref101","doi-asserted-by":"crossref","first-page":"9930","DOI":"10.1073\/pnas.171616898","article-title":"A neurohistochemical blueprint for pain-induced loss of appetite","volume":"98","author":"A Malick","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"100060","DOI":"10.1016\/j.ynpai.2021.100060","article-title":"Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection","volume":"9","author":"O Uddin","year":"2021","journal-title":"Neurobiol Pain"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1469-7580.2001.19810029.x","article-title":"Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation","volume":"198","author":"K L Hoskin","year":"2001","journal-title":"J Anat"},{"issue":"04","key":"ref104","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0306-4522(01)00303-7","article-title":"The periaqueductal grey matter modulates trigeminovascular input: a role in migraine?","volume":"106","author":"Y E Knight","year":"2001","journal-title":"Neuroscience"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.npep.2018.12.001","article-title":"Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats","volume":"73","author":"A M Pourrahimi","year":"2019","journal-title":"Neuropeptides"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"170651","DOI":"10.1016\/j.peptides.2021.170651","article-title":"The involvement of orexin 1 and cannabinoid 1 receptors within the ventrolateral periaqueductal gray matter in the modulation of migraine-induced anxiety and social behavior deficits of rats","volume":"146","author":"A M Pourrahimi","year":"2021","journal-title":"Peptides"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuropharm.2016.02.018","article-title":"Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid\/CB1 signaling in the mouse periaqueductal gray","volume":"105","author":"H J Lee","year":"2016","journal-title":"Neuropharmacology"},{"issue":"01","key":"ref108","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s10194-017-0747-9","article-title":"Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine","volume":"18","author":"Z Chen","year":"2017","journal-title":"J Headache Pain"},{"issue":"05","key":"ref109","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/ana.22537","article-title":"Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine","volume":"70","author":"C Mainero","year":"2011","journal-title":"Ann Neurol"},{"issue":"03","key":"ref110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1460-9568.2005.03918.x","article-title":"Both oral and caudal parts of the spinal trigeminal nucleus project to the somatosensory thalamus in the rat","volume":"21","author":"N Guy","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"01","key":"ref111","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.21994","article-title":"Thalamic sensitization transforms localized pain into widespread allodynia","volume":"68","author":"R Burstein","year":"2010","journal-title":"Ann Neurol"},{"issue":"08","key":"ref112","doi-asserted-by":"crossref","first-page":"e103929","DOI":"10.1371\/journal.pone.0103929","article-title":"Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety","volume":"9","author":"R Noseda","year":"2014","journal-title":"PLoS One"},{"issue":"01","key":"ref113","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1096-9861(19981012)400:1<125::AID-CNE9>3.0.CO;2-B","article-title":"Cells of origin of the trigeminohypothalamic tract in the rat","volume":"400","author":"A Malick","year":"1998","journal-title":"J Comp Neurol"},{"issue":"04","key":"ref114","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1152\/jn.2000.84.4.2078","article-title":"Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat","volume":"84","author":"A Malick","year":"2000","journal-title":"J Neurophysiol"},{"issue":"20","key":"ref115","doi-asserted-by":"crossref","first-page":"8827","DOI":"10.1523\/JNEUROSCI.0439-13.2013","article-title":"Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches","volume":"33","author":"C Robert","year":"2013","journal-title":"J Neurosci"},{"issue":"03","key":"ref116","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.nbd.2004.03.015","article-title":"Hypothalamic activation after stimulation of the superior sagittal sinus in the cat: a Fos study","volume":"16","author":"L Benjamin","year":"2004","journal-title":"Neurobiol Dis"},{"issue":"04","key":"ref117","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.25697","article-title":"Longitudinal neuroimaging over 30\u2009days: temporal characteristics of migraine","volume":"87","author":"L H Schulte","year":"2020","journal-title":"Ann Neurol"},{"issue":"13","key":"ref118","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1177\/0333102419867280","article-title":"Hypothalamic regulation of headache and migraine","volume":"39","author":"A May","year":"2019","journal-title":"Cephalalgia"},{"issue":"10","key":"ref119","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/j.1526-4610.2007.00776.x","article-title":"Hypothalamic activation in spontaneous migraine attacks","volume":"47","author":"M Denuelle","year":"2007","journal-title":"Headache"},{"issue":"08","key":"ref120","doi-asserted-by":"crossref","first-page":"e73022","DOI":"10.1371\/journal.pone.0073022","article-title":"Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats","volume":"8","author":"K Abdallah","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"ref121","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1111\/j.1460-9568.2006.05168.x","article-title":"Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat","volume":"24","author":"P R Holland","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"107981","DOI":"10.1016\/j.neuropharm.2020.107981","article-title":"Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats","volume":"178","author":"R Kooshki","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nbd.2014.10.022","article-title":"Evidence for orexinergic mechanisms in migraine","volume":"74","author":"J Hoffmann","year":"2015","journal-title":"Neurobiol Dis"},{"issue":"05","key":"ref124","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/0333102414544979","article-title":"Randomized controlled trial of the orexin receptor antagonist filorexant for migraine prophylaxis","volume":"35","author":"A Chabi","year":"2015","journal-title":"Cephalalgia"},{"issue":"05","key":"ref125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/0333102414566196","article-title":"Putting migraine to sleep: rexants as a preventive strategy","volume":"35","author":"P J Goadsby","year":"2015","journal-title":"Cephalalgia"},{"issue":"01","key":"ref126","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s10194-020-1079-8","article-title":"The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine","volume":"21","author":"K Warfvinge","year":"2020","journal-title":"J Headache Pain"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"113079","DOI":"10.1016\/j.expneurol.2019.113079","article-title":"Inhibition of nociceptive dural input to the trigeminocervical complex through oxytocinergic transmission","volume":"323","author":"E Garc\u00eda-Boll","year":"2020","journal-title":"Exp Neurol"},{"issue":"01","key":"ref128","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s10194-021-01299-3","article-title":"Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model","volume":"22","author":"Y Wang","year":"2021","journal-title":"J Headache Pain"},{"issue":"11","key":"ref129","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1177\/0333102420929023","article-title":"Dopaminergic symptoms in migraine: a cross-sectional study on 1148 consecutive headache center-based patients","volume":"40","author":"P Barbanti","year":"2020","journal-title":"Cephalalgia"},{"issue":"05","key":"ref130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0196-0644(95)70001-3","article-title":"Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache","volume":"26","author":"M Coppola","year":"1995","journal-title":"Ann Emerg Med"},{"issue":"03","key":"ref131","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jemermed.2015.03.023","article-title":"A randomized controlled trial of intravenous haloperidol vs","volume":"49","author":"M E Gaffigan","year":"2015","journal-title":"J Emerg Med"},{"issue":"04","key":"ref132","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.annemergmed.2007.09.027","article-title":"A randomized controlled trial of prochlorperazine versus metoclopramide for treatment of acute migraine","volume":"52","author":"B W Friedman","year":"2008","journal-title":"Ann Emerg Med"},{"issue":"10","key":"ref133","doi-asserted-by":"crossref","first-page":"e13306","DOI":"10.1371\/journal.pone.0013306","article-title":"Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate","volume":"5","author":"Q Barraud","year":"2010","journal-title":"PLoS One"},{"issue":"03","key":"ref134","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ana.21077","article-title":"Dopamine inhibits trigeminovascular transmission in the rat","volume":"61","author":"A Bergerot","year":"2007","journal-title":"Ann Neurol"},{"issue":"40","key":"ref135","doi-asserted-by":"crossref","first-page":"12532","DOI":"10.1523\/JNEUROSCI.2887-09.2009","article-title":"Neurons of the dopaminergic\/calcitonin gene-related peptide A11 cell group modulate neuronal firing in the trigeminocervical complex: an electrophysiological and immunohistochemical study","volume":"29","author":"A R Charbit","year":"2009","journal-title":"J Neurosci"},{"issue":"17","key":"ref136","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1212\/WNL.0000000000003861","article-title":"Dopamine D2\/D3 imbalance during migraine attack and allodynia in vivo","volume":"88","author":"A F DaSilva","year":"2017","journal-title":"Neurology"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in the cerebral cortex","volume":"7","author":"A Leao","year":"1944","journal-title":"J Neurophysiol"},{"issue":"08","key":"ref138","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1073\/pnas.071582498","article-title":"Mechanisms of migraine aura revealed by functional MRI in human visual cortex","volume":"98","author":"N Hadjikhani","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref139","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neuroimage.2014.05.021","article-title":"Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain","volume":"99","author":"E Santos","year":"2014","journal-title":"Neuroimage"},{"issue":"07","key":"ref140","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1177\/0271678X16689801","article-title":"Heterogeneous propagation of spreading depolarizations in the lissencephalic and gyrencephalic brain","volume":"37","author":"E Santos","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"issue":"01","key":"ref141","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10194-019-1001-4","article-title":"Spreading depression as a preclinical model of migraine","volume":"20","author":"A M Harriott","year":"2019","journal-title":"J Headache Pain"},{"issue":"03","key":"ref142","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1152\/physrev.00027.2014","article-title":"Spreading depression, spreading depolarizations, and the cerebral vasculature","volume":"95","author":"C Ayata","year":"2015","journal-title":"Physiol Rev"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(93)91644-8","article-title":"Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex","volume":"612","author":"M Fabricius","year":"1993","journal-title":"Brain Res"},{"issue":"04","key":"ref144","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neuron.2020.11.018","article-title":"Non-canonical glutamate signaling in a genetic model of migraine with aura","volume":"109","author":"P D Parker","year":"2021","journal-title":"Neuron"},{"issue":"11","key":"ref145","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1523\/JNEUROSCI.3390-16.2017","article-title":"Cortical spreading depression closes paravascular space and impairs glymphatic flow: implications for migraine headache","volume":"37","author":"A J Schain","year":"2017","journal-title":"J Neurosci"},{"issue":"30","key":"ref146","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1523\/JNEUROSCI.23-30-09888.2003","article-title":"Different mechanisms promote astrocyte Ca2+ waves and spreading depression in the mouse neocortex","volume":"23","author":"O Peters","year":"2003","journal-title":"J Neurosci"},{"issue":"15","key":"ref147","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1523\/JNEUROSCI.0721-07.2007","article-title":"High-resolution in vivo imaging of the neurovascular unit during spreading depression","volume":"27","author":"J Chuquet","year":"2007","journal-title":"J Neurosci"},{"issue":"10","key":"ref148","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/01.WCB.0000137057.92786.F3","article-title":"Pronounced hypoperfusion during spreading depression in mouse cortex","volume":"24","author":"C Ayata","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"issue":"02","key":"ref149","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/jcbfm.2011.148","article-title":"Cortical spreading depression impairs oxygen delivery and metabolism in mice","volume":"32","author":"I Yuzawa","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/brain\/awp338","article-title":"Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression","volume":"133","author":"J C Chang","year":"2010","journal-title":"Brain"},{"issue":"03","key":"ref151","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(97)00604-6","article-title":"The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat","volume":"232","author":"S J Read","year":"1997","journal-title":"Neurosci Lett"},{"issue":"01","key":"ref152","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jcbfm.1984.3","article-title":"Extracellular pH changes during spreading depression and cerebral ischemia: mechanisms of brain pH regulation","volume":"4","author":"W A Mutch","year":"1984","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2007.06.070","article-title":"Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance","volume":"1168","author":"S C Schock","year":"2007","journal-title":"Brain Res"},{"issue":"05","key":"ref154","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0271678X19859381","article-title":"Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex","volume":"40","author":"T Takizawa","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"issue":"07","key":"ref155","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1523\/JNEUROSCI.11-07-02187.1991","article-title":"Spreading depression increases immunohistochemical staining of glial fibrillary acidic protein","volume":"11","author":"R P Kraig","year":"1991","journal-title":"J Neurosci"},{"issue":"16","key":"ref156","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1177\/0333102411425865","article-title":"Chronic daily cortical spreading depressions suppress spreading depression susceptibility","volume":"31","author":"I Sukhotinsky","year":"2011","journal-title":"Cephalalgia"},{"issue":"04","key":"ref157","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/0333102417702132","article-title":"Astrocyte-mediated inflammation in cortical spreading depression","volume":"38","author":"A Ghaemi","year":"2018","journal-title":"Cephalalgia"},{"issue":"06","key":"ref158","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/awx085","article-title":"Inhibition of the P2\u2009\u00d7\u20097-PANX1 complex suppresses spreading depolarization and neuroinflammation","volume":"140","author":"S P Chen","year":"2017","journal-title":"Brain"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.1231897","article-title":"Spreading depression triggers headache by activating neuronal Panx1 channels","volume":"339","author":"H Karatas","year":"2013","journal-title":"Science"},{"issue":"01","key":"ref160","first-page":"99","article-title":"Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1","volume":"119","author":"K Eikermann-Haerter","year":"2009","journal-title":"J Clin Invest"},{"issue":"01","key":"ref161","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.21815","article-title":"High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1\u2009S218L mice","volume":"67","author":"A M van den Maagdenberg","year":"2010","journal-title":"Ann Neurol"},{"issue":"06","key":"ref162","doi-asserted-by":"crossref","first-page":"e1002129","DOI":"10.1371\/journal.pgen.1002129","article-title":"Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2","volume":"7","author":"L Leo","year":"2011","journal-title":"PLoS Genet"},{"issue":"03","key":"ref163","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1523\/JNEUROSCI.13-03-01167.1993","article-title":"Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms","volume":"13","author":"M A Moskowitz","year":"1993","journal-title":"J Neurosci"},{"issue":"26","key":"ref164","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.0511-10.2010","article-title":"Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura","volume":"30","author":"X Zhang","year":"2010","journal-title":"J Neurosci"},{"issue":"05","key":"ref165","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/ana.22329","article-title":"Activation of central trigeminovascular neurons by cortical spreading depression","volume":"69","author":"X Zhang","year":"2011","journal-title":"Ann Neurol"},{"issue":"30","key":"ref166","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1523\/JNEUROSCI.0576-17.2017","article-title":"Selective inhibition of trigeminovascular neurons by fremanezumab: a humanized monoclonal anti-CGRP antibody","volume":"37","author":"A Melo-Carrillo","year":"2017","journal-title":"J Neurosci"},{"issue":"03","key":"ref167","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0333102417735845","article-title":"CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior","volume":"39","author":"A Filiz","year":"2019","journal-title":"Cephalalgia"},{"issue":"04","key":"ref168","doi-asserted-by":"crossref","first-page":"ENEURO.0116","DOI":"10.1523\/ENEURO.0116-18.2018","article-title":"Loss of blood-brain barrier integrity in a KCl-induced model of episodic headache enhances CNS drug delivery","volume":"5","author":"K E Cottier","year":"2018","journal-title":"eNeuro"},{"issue":"01","key":"ref169","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1038\/s41598-020-67948-w","article-title":"Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant","volume":"10","author":"C Tang","year":"2020","journal-title":"Sci Rep"},{"issue":"01","key":"ref170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ana.25926","article-title":"Optogenetic spreading depression elicits trigeminal pain and anxiety behavior","volume":"89","author":"A M Harriott","year":"2021","journal-title":"Ann Neurol"},{"issue":"12","key":"ref171","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/0333102414526069","article-title":"Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine","volume":"34","author":"T J Schwedt","year":"2014","journal-title":"Cephalalgia"},{"issue":"11","key":"ref172","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11916-014-0458-8","article-title":"Migraine is associated with altered processing of sensory stimuli","volume":"18","author":"A M Harriott","year":"2014","journal-title":"Curr Pain Headache Rep"},{"issue":"05","key":"ref173","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/head.12081","article-title":"Atypical resting-state functional connectivity of affective pain regions in chronic migraine","volume":"53","author":"T J Schwedt","year":"2013","journal-title":"Headache"},{"issue":"01","key":"ref174","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0022-510X(96)00044-5","article-title":"Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation","volume":"139","author":"W van der Kamp","year":"1996","journal-title":"J Neurol Sci"},{"issue":"05","key":"ref175","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1212\/WNL.48.5.1462","article-title":"Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine","volume":"48","author":"W van der Kamp","year":"1997","journal-title":"Neurology"},{"key":"ref176","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1129-2377-14-65","article-title":"Habituation and sensitization in primary headaches","volume":"14","author":"G Coppola","year":"2013","journal-title":"J Headache Pain"},{"issue":"05","key":"ref177","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1468-2982.1998.1805261.x","article-title":"Interictal potentiation of passive \u201coddball\u201d auditory event-related potentials in migraine","volume":"18","author":"W Wang","year":"1998","journal-title":"Cephalalgia"},{"issue":"04","key":"ref178","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1460-9568.2009.06859.x","article-title":"Visual paired-pulse stimulation reveals enhanced visual cortex excitability in migraineurs","volume":"30","author":"O H\u00f6ffken","year":"2009","journal-title":"Eur J Neurosci"},{"issue":"29","key":"ref179","doi-asserted-by":"crossref","first-page":"17320","DOI":"10.1073\/pnas.2007402117","article-title":"Selective amplification of ipRGC signals accounts for interictal photophobia in migraine","volume":"117","author":"H McAdams","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"02","key":"ref180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nn.2475","article-title":"A neural mechanism for exacerbation of headache by light","volume":"13","author":"R Noseda","year":"2010","journal-title":"Nat Neurosci"},{"issue":"28","key":"ref181","doi-asserted-by":"crossref","first-page":"E5683","DOI":"10.1073\/pnas.1708361114","article-title":"Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine","volume":"114","author":"R Noseda","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"09","key":"ref182","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/head.13917","article-title":"Stimulation of posterior thalamic nuclei induces photophobic behavior in mice","volume":"60","author":"L P Sowers","year":"2020","journal-title":"Headache"},{"issue":"03","key":"ref183","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/WCO.0000000000000691","article-title":"The unique role of the trigeminal autonomic reflex and its modulation in primary headache disorders","volume":"32","author":"M M\u00f6ller","year":"2019","journal-title":"Curr Opin Neurol"},{"issue":"04","key":"ref184","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1474-4422(02)00104-7","article-title":"Pathophysiology of cluster headache: a trigeminal autonomic cephalgia","volume":"1","author":"P J Goadsby","year":"2002","journal-title":"Lancet Neurol"},{"issue":"01","key":"ref185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1526-4610.2011.02028.x","article-title":"Cluster headache in the United States of America: demographics, clinical characteristics, triggers, suicidality, and personal burden","volume":"52","author":"T D Rozen","year":"2012","journal-title":"Headache"},{"issue":"14","key":"ref186","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1177\/0333102419851815","article-title":"The biological clock in cluster headache: a review and hypothesis","volume":"39","author":"W C Naber","year":"2019","journal-title":"Cephalalgia"},{"key":"ref187","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0140-6736(98)02470-2","article-title":"Hypothalamic activation in cluster headache attacks","volume":"352","author":"A May","year":"1998","journal-title":"Lancet"},{"issue":"01","key":"ref188","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10194-008-0085-z","article-title":"Functional magnetic resonance imaging in episodic cluster headache","volume":"10","author":"N Morelli","year":"2009","journal-title":"J Headache Pain"},{"issue":"14","key":"ref189","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/WNL.0000000000001442","article-title":"Abnormal coactivation of the hypothalamus and salience network in patients with cluster headache","volume":"84","author":"E Qiu","year":"2015","journal-title":"Neurology"},{"issue":"02","key":"ref190","doi-asserted-by":"crossref","first-page":"e57896","DOI":"10.1371\/journal.pone.0057896","article-title":"Abnormal brain functional connectivity of the hypothalamus in cluster headaches","volume":"8","author":"E Qiu","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"ref191","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1046\/j.1468-2982.1998.1810664.x","article-title":"Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache","volume":"18","author":"M Leone","year":"1998","journal-title":"Cephalalgia"},{"issue":"01","key":"ref192","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1468-2982.1982.0201001.x","article-title":"Changes in the 24-hour prolactin pattern in cluster headache","volume":"2","author":"A Polleri","year":"1982","journal-title":"Cephalalgia"},{"issue":"02","key":"ref193","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/jnnp.50.2.207","article-title":"Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission","volume":"50","author":"E Waldenlind","year":"1987","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"08","key":"ref194","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3598","article-title":"Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine","volume":"48","author":"P Gormley","year":"2016","journal-title":"Nat Genet"},{"issue":"05","key":"ref195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/0333102419877834","article-title":"Migraine-associated gene expression in cell types of the central and peripheral nervous system","volume":"40","author":"A Vgontzas","year":"2020","journal-title":"Cephalalgia"},{"issue":"02","key":"ref196","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41588-021-00990-0","article-title":"Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles","volume":"54","author":"H Hautakangas","year":"2022","journal-title":"Nat Genet"},{"issue":"02","key":"ref197","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.26150","article-title":"Genome-wide association study identifies risk loci for cluster headache","volume":"90","author":"E O'Connor","year":"2021","journal-title":"Ann Neurol"},{"issue":"01","key":"ref198","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s10194-018-0848-0","article-title":"The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system","volume":"19","author":"K Messlinger","year":"2018","journal-title":"J Headache Pain"},{"issue":"20","key":"ref199","doi-asserted-by":"crossref","first-page":"e2488","DOI":"10.1212\/WNL.0000000000011930","article-title":"Effect of adrenomedullin on migraine-like attacks in patients with migraine: a randomized crossover study","volume":"96","author":"H Ghanizada","year":"2021","journal-title":"Neurology"},{"key":"ref200","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fneur.2017.00163","article-title":"Cholinergic nociceptive mechanisms in rat meninges and trigeminal ganglia: potential implications for migraine pain","volume":"8","author":"I Shelukhina","year":"2017","journal-title":"Front Neurol"},{"issue":"11","key":"ref201","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1021\/cn500083e","article-title":"Targeting TRP channels for novel migraine therapeutics","volume":"5","author":"G Dussor","year":"2014","journal-title":"ACS Chem Neurosci"},{"issue":"01","key":"ref202","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s10194-022-01390-3","article-title":"Correction to: migraine-relevant sex-dependent activation of mouse meningeal afferents by TRPM3 agonists","volume":"23","author":"G Krivoshein","year":"2022","journal-title":"J Headache Pain"}],"container-title":["Seminars in Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1757924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T18:59:57Z","timestamp":1701284397000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1757924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":202,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1757924","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0271-8235","1098-9021"],"issn-type":[{"value":"0271-8235","type":"print"},{"value":"1098-9021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}