{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:22:42Z","timestamp":1752981762725},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Assisted reproductive techniques (ART) allow infertile couples to conceive. Use of hormones to obtain a controlled ovarian stimulation and an adequate growth of the endometrium preparatory for embryo implantation are not riskless. Among others, thrombotic events can occur during the ovulation induction or pregnancy following ART. As the number of women approaching ART to conceive is steadily increasing, the issue of thrombotic risk in this setting is relevant. Data on the weight of each risk factor and on potential benefit of thromboprophylaxis are largely lacking. In this review, we discuss risk of venous thromboembolism during pregnancy following ART, with a focus on general (i.e.: age, body mass index, thrombophilia, bed rest, transfusions) and ART-specific (i.e., polycystic ovarian syndrome, ovarian hyperstimulation syndrome) risk factors. We also attempt to provide some suggestions to guide clinical practice, based on available data and studies performed outside ART.<\/jats:p>","DOI":"10.1055\/s-0042-1758062","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:55:33Z","timestamp":1668214533000},"page":"330-336","source":"Crossref","is-referenced-by-count":3,"title":["The ART of Thromboprophylaxis in the Prevention of Gestational Venous Thromboembolism"],"prefix":"10.1055","volume":"49","author":[{"given":"Elvira","family":"Grandone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Foggia, Foggia, Italy"},{"name":"Thrombosis and Haemostasis Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d Foggia, Italy"},{"name":"Department of Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Barcellona","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Department of Medical Science and Public Health, University of Cagliari, Azienda Ospedaliero-Universitaria di Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Intrieri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Science \u201cV. Tiberio,\u201d University of Molise, Campobasso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tiscia","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada"},{"name":"School of Baccalaureate Nursing, St Lawrence College, Kingston, Ontario, Canada"},{"name":"Department of Clinical Pathology, School of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-0041-1736188","article-title":"Approach to the evaluation and treatment of venous thromboembolism in pregnancy","volume":"39","author":"B Brenner","year":"2021","journal-title":"Semin Reprod Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.trsl.2020.06.011","article-title":"Hormones and thrombosis: risk across the reproductive years and beyond","volume":"225","author":"N Machin","year":"2020","journal-title":"Transl Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.thromres.2021.03.010","article-title":"Effect of blood loss during caesarean section on coagulation parameters","volume":"202","author":"A Wasserloos","year":"2021","journal-title":"Thromb Res"},{"issue":"01","key":"ref4","first-page":"13","article-title":"Pulmonary embolism associated with transfusion after severe post-partum haemorrhage: is less more?","volume":"18","author":"E Grandone","year":"2020","journal-title":"Blood Transfus"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0301-2115(00)00495-4","article-title":"Activated protein C resistance during in vitro fertilization treatment","volume":"95","author":"J Curvers","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/GCO.0b013e328329c2b8","article-title":"The \u2018ART\u2019 of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology","volume":"21","author":"W S Chan","year":"2009","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"S 03","key":"ref8","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0049-3848(09)70127-6","article-title":"Prophylaxis of VTE in women - during assisted reproductive techniques","volume":"123","author":"S M Nelson","year":"2009","journal-title":"Thromb Res"},{"issue":"S 01","key":"ref9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0049-3848(13)00023-6","article-title":"Venous thrombosis during assisted reproduction: novel risk reduction strategies","volume":"131","author":"S M Nelson","year":"2013","journal-title":"Thromb Res"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/14779072.2017.1319279","article-title":"The prevention and treatment of venous thromboembolism in pregnancy","volume":"15","author":"M Villani","year":"2017","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"02","key":"ref11","first-page":"304","article-title":"Venous thromboembolism in pregnant and puerperal women in Denmark 1995-2005. 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