{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:05:06Z","timestamp":1791813906976,"version":"4.3.4"},"reference-count":55,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review summarizes the time that has passed from the initial registration of the cells that turned out to be platelets up to today's advanced methodologies in platelet investigation. The first reports of \u201cgranular masses\u201d appeared in the 1840s, but these \u201cgranular masses\u201d remained an unsolved mystery until the 1870s. The breakthrough came in the 1873\u20131882 period. The cells that later turned out to be platelets were further identified by the German Professor Max Schultze, and later by Osler, who described their disk-like structure. These initial descriptions of platelets were expanded by impressive studies performed by the Italian Pathologist Bizzozero who uncovered the anatomy of platelets and described their role, first in experimental thrombosis and later in the clotting process. Nearly 20 years later, in 1906, Wright published the discovery of megakaryocytes as platelet precursors. Shortly thereafter, the clinical proof of concept illustrating the pivotal role of platelets in arresting bleeding was revealed by Duke who introduced the bleeding time test, also in this period. To investigate platelet function more specifically, light transmission aggregometry was introduced in 1962 and remains the gold standard today. This method inspired the development of several devices employing whole blood using different principles for evaluating platelet function. As of today, flow cytometry is the most advanced method and holds promise to provide new insights into platelet activation. Additionally, advances in genetic testing by the use of next-generation sequencing will allow further improvement of our ability to diagnose inherited platelet disorders.<\/jats:p>","DOI":"10.1055\/s-0042-1758119","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:55:33Z","timestamp":1668214533000},"page":"272-278","source":"Crossref","is-referenced-by-count":8,"title":["Crucial Stepping Stones in Platelet History"],"prefix":"10.1055","volume":"49","author":[{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"issue":"02","key":"ref1","first-page":"237","article-title":"A note from history: the discovery of blood cells","volume":"33","author":"S I Hajdu","year":"2003","journal-title":"Ann Clin Lab Sci"},{"issue":"S 01","key":"ref2","first-page":"S13","article-title":"Platelets, inflammation and tissue regeneration","volume":"105","author":"A T Nurden","year":"2011","journal-title":"Thromb Haemost"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1182\/blood-2010-08-304808","article-title":"A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing","volume":"117","author":"W Feng","year":"2011","journal-title":"Blood"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis","volume":"20","author":"M Labelle","year":"2011","journal-title":"Cancer Cell"},{"issue":"01","key":"ref5","first-page":"18","article-title":"Platelet contribution to cancer cell growth and migration: the role of platelet growth factors","volume":"18","author":"A Poggi","year":"1988","journal-title":"Haemostasis"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1182\/blood.V3.10.1073.1073","article-title":"Historical notes on blood platelets","volume":"3","author":"L M Tocantins","year":"1948","journal-title":"Blood"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2141.1967.tb00769.x","article-title":"Why the platelets were discovered","volume":"13","author":"A H Robb-Smith","year":"1967","journal-title":"Br J Haematol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.2174\/138945011797635858","article-title":"Historical observations on the discovery of platelets, platelet function testing and the first antiplatelet agent","volume":"12","author":"S R Steinhubl","year":"2011","journal-title":"Curr Drug Targets"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S0025727300056064","article-title":"Max Schultze and the living, moving, phagocytosing leucocytes: 1865","volume":"38","author":"D B Brewer","year":"1994","journal-title":"Med Hist"},{"key":"ref10","first-page":"391","article-title":"An account of certain organisms occurring in the liquor sanguinis","volume":"22","author":"W Osler","year":"1874","journal-title":"Proc Roy Soc"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2141.2006.06036.x","article-title":"Max Schultze (1865), G. 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