{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:27:43Z","timestamp":1768879663432,"version":"3.49.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Squamous cell carcinoma (SCC) of the maxillary alveolus is a relatively rare disease. There is lack of data on this subsite as compared with other sites. The factors that affect survival in cases of maxillary alveolar SCC are tumor stage, local and cervical metastases, histological grading, and the margin status.<\/jats:p><jats:p>\n          Objectives\u2003To evaluate the overall survival (OS), the disease free survival (DFS), and the complex interaction and effects of margin status, histological differentiation, habits (such as smoking and the use of smokeless tobacco products), and cervical and distant metastases based on clinicopathological data.<\/jats:p><jats:p>\n          Methods\u2003We examined the electronic database at our hospital from 2003 to 2017. We included all cases with a histopathological diagnosis of SCC of the maxillary alveolus. Tumors originating primarily from the maxillary alveolus were included, while those originating from adjacent subsites, like the hard palate, the buccal mucosa or the maxillary sinus were excluded. We also excluded all the patients who were not operated on with a curative intent.<\/jats:p><jats:p>\n          Results\u2003More than half of the patients had stage-IV tumors at the time of presentation, while only one fourth of them had nodal metastasis. The rate of recurrence increased in cases of primary tumors in advanced stages and the degree of histological differentiation. The 2-year and 5-year OS rates were of 54.5% (18 patients) and 30.3% (10 patients) respectively.<\/jats:p><jats:p>\n          Conclusion\u2003Primary tumors in advanced stages, histological grade, and presence of nodal metastasis are poor prognostic markers in terms of long-term survival.<\/jats:p>","DOI":"10.1055\/s-0042-1758214","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T22:43:17Z","timestamp":1698100997000},"page":"e559-e564","source":"Crossref","is-referenced-by-count":4,"title":["Survival Outcomes and Patterns of Failure in Maxillary Alveolus Squamous Cell Carcinoma"],"prefix":"10.1055","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-0270","authenticated-orcid":false,"given":"Muhammad Umar","family":"Qayyum","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology\u2013Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"},{"name":"Department of Maxillofacial Surgery, Combined Military Hospital Lahore, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Ali","family":"Keerio","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology\u2013Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Faisal","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology\u2013Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology\u2013Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raza","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology\u2013Head and Neck Surgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Jamshed","sequence":"additional","affiliation":[{"name":"Department of Clinical and Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Punjab, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0757.2011.00401.x","article-title":"Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology","volume":"57","author":"N W Johnson","year":"2011","journal-title":"Periodontol 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