{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:37:20Z","timestamp":1792975040010,"version":"4.5.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Tinnitus etiopathogenesis is still unclear and treatment options are controversial despite current advances in medicine.<\/jats:p><jats:p>\n          Objectives\u2003To analyze the correlation between patients' symptom scores, systemic inflammation, and trombosis biomarkers.<\/jats:p><jats:p>\n          Methods\u2003In this prospective study, we evaluated the degree of complaints of subjective tinnitus patients with the tinnitus severity index (TSI) and tinnitus handicap inventory (THI), and correlated these symptom scores with hematological parameters such as the neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR), mean thrombocyte volume (MPV), and platelet distribution width (PDW).<\/jats:p><jats:p>\n          Results\u2003A total of 44 patients with subjective tinnitus, 25 (56.8%) men and 19 (43.2%) women, were included in this study. The mean age of the patients was 42.3\u2009\u00b1\u200914.8 years. When the correlation between TSI and NLR, PLR, PDW, and MPV values of the patients were analyzed, no statistically significant correlation was found between TSI, NLR, and PLR (p\u2009&gt;\u20090.05). However, there was a statistically weak positive correlation between TSI, MPV, and PDW.(p\u2009&lt;\u20090.05). When the correlation between THI and NLR, PLR, PDW, and MPV values of the patients were analyzed, no statistically significant correlation was found between THI, NLR, and PLR (p\u2009&gt;\u20090.05). There was a statistically weak positive correlation between THI, MPV, and PDW (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003We were unable to detect any relationship between systemic inflammation markers (NLR and PLR) and symptom scores, but a weakly positive correlation was observed between thrombosis markers (MPV and PDW) and symptom scores, and as the subclinical thrombosis markers elevated, so did the symptom scores.<\/jats:p>","DOI":"10.1055\/s-0042-1758216","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T22:43:17Z","timestamp":1698100997000},"page":"e608-e612","source":"Crossref","is-referenced-by-count":6,"title":["Correlation of Tinnitus Severity Index and Tinnitus Handicap Inventory with Hematological Parameters in Patients with Subjective Tinnitus"],"prefix":"10.1055","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-1987","authenticated-orcid":false,"given":"Demet","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Adana City Training and Research Hospital, Adana, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-7188","authenticated-orcid":false,"given":"Mehmet Celalettin","family":"Cihan","sequence":"additional","affiliation":[{"name":"Department of Audiology, Cappadocia University, Nev\u015fehir, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus","volume":"382","author":"D Baguley","year":"2013","journal-title":"Lancet"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/14992027.2020.1849829","article-title":"Prevalence of tinnitus in a sample of 43,064 children in Warsaw, Poland","volume":"60","author":"D Raj-Koziak","year":"2021","journal-title":"Int J Audiol"},{"issue":"01","key":"ref3","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"R Zahorec","year":"2001","journal-title":"Bratisl Lek Listy"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0007-1935(17)50942-2","article-title":"The Reaction of the White Blood Cells at Parturition in the Sow","volume":"109","author":"D Luke","year":"1953","journal-title":"Br Vet J"},{"issue":"01","key":"ref5","first-page":"28","article-title":"Platelet distribution width: a simple, practical and specific marker of activation of coagulation","volume":"14","author":"E Vagdatli","year":"2010","journal-title":"Hippokratia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"N105","DOI":"10.1097\/00003246-200004001-00013","article-title":"Apoptosis in sepsis","volume":"28","author":"R Mahidhara","year":"2000","journal-title":"Crit Care Med"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/00003246-199904000-00026","article-title":"Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications","volume":"27","author":"T Menges","year":"1999","journal-title":"Crit Care Med"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jso.20329","article-title":"Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer","volume":"91","author":"S R Walsh","year":"2005","journal-title":"J Surg Oncol"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ahj.2007.06.043","article-title":"Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting","volume":"154","author":"P H Gibson","year":"2007","journal-title":"Am Heart J"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/ehf2.13390","article-title":"The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study","volume":"8","author":"B Dahlen","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MAO.0000000000001832","article-title":"Epidemiology of Clinically Significant Tinnitus: A 10-Year Trend From Nationwide Health Claims Data in South Korea","volume":"39","author":"H M Lee","year":"2018","journal-title":"Otol Neurotol"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1055\/s-0041-1727283","article-title":"Mean Platelet Volume Predicts Severe COVID-19 Illness","volume":"47","author":"G Lippi","year":"2021","journal-title":"Semin Thromb Hemost"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/0003319713520068","article-title":"Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure","volume":"65","author":"M Cetin","year":"2014","journal-title":"Angiology"},{"issue":"04","key":"ref14","first-page":"379","article-title":"Relationship between First Values of Red Cell Distribution Width, Mean Platelet Volume, Platelet Distribution Width, and Hospital Mortality in Acute Deep Venous Thrombosis","volume":"30","author":"S O\u011fuz","year":"2021","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6633845","DOI":"10.1155\/2021\/6633845","article-title":"Platelet Distribution Width and Mortality in Hemodialysis Patients","volume":"2021","author":"W Ruiyan","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamaoto.2016.1700","article-title":"Prevalence, Severity, Exposures, and Treatment Patterns of Tinnitus in the United States","volume":"142","author":"J M Bhatt","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"e041290","DOI":"10.1136\/bmjopen-2020-041290","article-title":"Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis","volume":"10","author":"P Dawes","year":"2020","journal-title":"BMJ Open"},{"key":"ref18","first-page":"24","article-title":"Tinnitus prevalence in New Zealand","volume":"128","author":"B P Wu","year":"2015","journal-title":"N Z Med J"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"e0127578","DOI":"10.1371\/journal.pone.0127578","article-title":"Analysis of the prevalence and associated risk factors of tinnitus in adults","volume":"10","author":"H-J Kim","year":"2015","journal-title":"PLoS One"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.anl.2018.04.001","article-title":"Characteristics of tinnitus found in anemia patients and analysis of population-based survey","volume":"45","author":"W Sunwoo","year":"2018","journal-title":"Auris Nasus Larynx"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/ehp.8564111","article-title":"Free-radical chemistry of cigarette smoke and its toxicological implications","volume":"64","author":"D F Church","year":"1985","journal-title":"Environ Health Perspect"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/14992027.2010.551220","article-title":"Tinnitus and its risk factors in the Beaver Dam offspring study","volume":"50","author":"D M Nondahl","year":"2011","journal-title":"Int J Audiol"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"264","DOI":"10.5505\/ejm.2018.02703","article-title":"A Retrospective Analysis of Haemotologic Parameters in Patients with Bilateral Tinnitus","volume":"23","author":"U D\u00fczenli","year":"2018","journal-title":"East J Med"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1538-7836.2009.03673.x","article-title":"Mean platelet volume: a quick, easy determinant of thrombotic risk?","volume":"8","author":"S J Machin","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2147\/VHRM.S126105","article-title":"Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow","volume":"13","author":"M Y\u0131lmaz","year":"2017","journal-title":"Vasc Health Risk Manag"},{"issue":"02","key":"ref27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1017\/S0022215115003254","article-title":"Prognostic value of mean platelet volume on tinnitus","volume":"130","author":"O Kemal","year":"2016","journal-title":"J Laryngol Otol"},{"issue":"01","key":"ref28","first-page":"16","article-title":"The Relationship between Tinnitus, Mean Platelet Volume and Neutrophile\/ Lymphocyte Ratio-Investigation on the New Focus of the literature. Online J Otolaryngol","volume":"7","author":"F Akil","year":"2017","journal-title":"Online Journal of Otolaryngology"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2399\/jmu.2015003005","article-title":"Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus","volume":"5","author":"A Bayram","year":"2016","journal-title":"ENT Updates."},{"issue":"02","key":"ref30","first-page":"1","article-title":"Tinnitus Olan Hastalarda Hematolojik Parametrelerin Analizi ve Prognostik \u00d6nemi","volume":"5","author":"N Bilal","year":"2016","journal-title":"Kocaeli Med J."},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0022215117002481","article-title":"Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus","volume":"132","author":"B Ulusoy","year":"2018","journal-title":"J Laryngol Otol"},{"key":"ref32","first-page":"S18","article-title":"Mean platelet volume and neutrophil to lymphocyte ratio in patients with tinnitus: a case-control study","author":"S Yildiz","year":"2020","journal-title":"Rev Bras Otorrinolaringol (Engl Ed)"},{"issue":"06","key":"ref33","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1017\/S0022215115000845","article-title":"Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study","volume":"129","author":"I Ozbay","year":"2015","journal-title":"J Laryngol Otol"},{"key":"ref34","volume-title":"Hacmi ve N\u00f6trofil\/Lenfosit Oran\u0131 De\u011ferlerinin Tinnitus Etyopatogenezindeki Rol\u00fcn\u00fcn Ara\u015ft\u0131r\u0131lmas\u0131 [Tez]","author":"S Y\u0131ld\u0131z","year":"2017"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"e420","DOI":"10.1097\/SCS.0000000000002693","article-title":"Can Platelet Indices Be New Biomarkers for Subjective Tinnitus?","volume":"27","author":"F Y\u00fcksel","year":"2016","journal-title":"J Craniofac Surg"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1007\/s00405-016-3942-4","article-title":"Increased mean platelet volume in patients with idiopathic subjective tinnitus","volume":"273","author":"Y Sar\u0131kaya","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-1758216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:54:45Z","timestamp":1730807685000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-1758216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":35,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,10,23]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-1758216","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]}}}