{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:37:17Z","timestamp":1740148637080,"version":"3.37.3"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Nosso objetivo \u00e9 descrever um modelo experimental para estudo de fraturas de f\u00eamur em ratos ap\u00f3s exposi\u00e7\u00e3o a radia\u00e7\u00e3o ionizante, demonstrando uma forma de aplica\u00e7\u00e3o de uma subst\u00e2ncia para an\u00e1lise, o m\u00e9todo de padroniza\u00e7\u00e3o de fratura e irradia\u00e7\u00e3o e a forma de avalia\u00e7\u00e3o de sua efic\u00e1cia com base em estudos radiogr\u00e1ficos.<\/jats:p><jats:p>\n          M\u00e9todos\u2003Utilizamos 24 ratos divididos em dois grupos de 12 animais cada. O grupo ESTUDO foi exposto \u00e0 radia\u00e7\u00e3o ionizante e tratado com soro fisiol\u00f3gico, enquanto o grupo CONTROLE n\u00e3o foi exposto \u00e0 radia\u00e7\u00e3o e foi tratado com soro fisiol\u00f3gico. Todos os animais foram submetidos \u00e0 fratura padronizada do f\u00eamur direito e sua fixa\u00e7\u00e3o com fio intramedular. A efic\u00e1cia da consolida\u00e7\u00e3o \u00f3ssea foi determinada por exame radiogr\u00e1fico.<\/jats:p><jats:p>\n          Resultados\u2003A cicatriza\u00e7\u00e3o de fraturas foi mais eficiente em ossos n\u00e3o expostos \u00e0 radia\u00e7\u00e3o ionizante (p\u2009=\u20090,012). Todas as fraturas atenderam aos crit\u00e9rios de serem simples, diafis\u00e1rias, transversas ou obl\u00edquas curtas.<\/jats:p><jats:p>\n          Conclus\u00e3o\u2003O modelo experimental apresentado \u00e9 uma boa alternativa para o estudo de fraturas em ossos irradiados em ratos.<\/jats:p>","DOI":"10.1055\/s-0042-1758359","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T22:46:39Z","timestamp":1688510799000},"page":"e653-e658","source":"Crossref","is-referenced-by-count":0,"title":["Fratura em f\u00eamur irradiado de rato: Descri\u00e7\u00e3o de um modelo experimental e avalia\u00e7\u00e3o de sua efic\u00e1cia"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-0700","authenticated-orcid":false,"given":"Cl\u00e1udio Beling Gon\u00e7alves","family":"Soares","sequence":"additional","affiliation":[{"name":"M\u00e9dico Preceptor, Departamento de Cirurgia, Faculdade de Medicina Federal, Universidade de Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-3506","authenticated-orcid":false,"given":"Ivana Duval de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Professor, Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal, Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5679","authenticated-orcid":false,"given":"Luiz Eduardo Moreira","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Professor, Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal, Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-8805","authenticated-orcid":false,"given":"M\u00e1rcia Antoniazi","family":"Michelin","sequence":"additional","affiliation":[{"name":"Professor, Universidade Federal do Tri\u00e2ngulo Mineiro, Instituto de Oncologia, Uberaba, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-0709","authenticated-orcid":false,"given":"Carla Jorge","family":"Machado","sequence":"additional","affiliation":[{"name":"Professor, Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal, Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-2061","authenticated-orcid":false,"given":"Marcelo Peixoto","family":"Silveira","sequence":"additional","affiliation":[{"name":"M\u00e9dico Ortopedista, Departamento de Ortopedia, Faculdade de Medicina, Federal, Universidade de Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"issue":"06","key":"ref1","first-page":"902","article-title":"Fratura patol\u00f3gica ap\u00f3s radioterapia: Revis\u00e3o sistem\u00e1tica da literatura","volume":"65","author":"C Soares","year":"2019","journal-title":"J Brazilian Med Assoc"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/jor.22661","article-title":"Can OP-1 stimulate union in a rat model of pathological fracture post treatment for soft tissue sarcoma?","volume":"32","author":"F Nicholls","year":"2014","journal-title":"J Orthop Res"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/jor.22351","article-title":"Effects of radiation and surgery on healing of femoral fractures in a rat model","volume":"31","author":"F Nicholls","year":"2013","journal-title":"J Orthop Res"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0030-5898(20)30385-0","article-title":"Current approaches to experimental bone grafting","volume":"18","author":"J M Lane","year":"1987","journal-title":"Orthop Clin North Am"},{"issue":"04","key":"ref5","first-page":"1041","article-title":"The effect of ibandronate on fracture healing in rat tibia model","volume":"2","author":"M Dokmeci","year":"2016","journal-title":"SM J Orthop"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1590\/S0104-42302010000100024","article-title":"Aspectos fundamentais da experimenta\u00e7\u00e3o animal - 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