{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:15:16Z","timestamp":1765041316660,"version":"3.37.3"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Some studies show an association between the apolipoprotein E \u03b54 allele (ApoE\u03b54) and obstructive sleep apnea syndrome (OSAS), and other studies, an association between ApoE\u03b54 and excessive daytime sleepiness (EDS), but there are no data in the literature on the interaction between EDS, cognitive function, and ApoE\u03b54 in patients with OSA.<\/jats:p><jats:p>\n          Objective\u2003To examine the cognitive function of adults with and without EDS and with and without ApoE\u03b54.<\/jats:p><jats:p>\n          Methods\u2003A total of 21 male and female patients aged between 33 and 79 years, underwent a clinical interview, ApoE genotyping, neuropsychological evaluation, polysomnography, and the application of the Epworth Sleepiness Scale.<\/jats:p><jats:p>\n          Results\u2003Excessive daytime sleepiness was associated with lower intelligence quotient (IQ; total performance) and worse immediate visual memory, regardless of the ApoE genotype. Patients carrying the ApoE\u03b53\/\u03b54 genotype had a worse performance in divided attention, constructional praxis, perceptual organization, and cognitive flexibility. A combination of the \u03b54 allele and EDS potentiates the negative effect on cognition, except for immediate visual memory. In this case, patients had a worse performance in terms of processing speed, selective attention, and visuomotor coordination.<\/jats:p><jats:p>\n          Conclusions\u2003Excessive daytime sleepiness and the ApoE\u03b53\/\u03b54 genotype are associated with worse cognitive performance in OSA patients. The combination of EDS and \u03b54 allele potentiates cognitive impairment.<\/jats:p>","DOI":"10.1055\/s-0042-1758399","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T23:35:12Z","timestamp":1672270512000},"page":"1104-1111","source":"Crossref","is-referenced-by-count":3,"title":["Interaction between apolipoprotein E genotypes, excessive daytime sleepiness, and cognitive function in obstructive sleep apnea patients"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-7016","authenticated-orcid":false,"given":"Fernanda Maurer","family":"Balthazar","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor Neuro-Sono, Disciplina de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-7049","authenticated-orcid":false,"given":"Walter Andr\u00e9 dos Santos","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor Neuro-Sono, Disciplina de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-0629","authenticated-orcid":false,"given":"James Richard","family":"Hunter","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Medicina, Disciplina de Infectologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-8198","authenticated-orcid":false,"given":"Gilmar Fernandes do","family":"Prado","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor Neuro-Sono, Disciplina de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-3023","authenticated-orcid":false,"given":"Luciane Bizari Coin de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor Neuro-Sono, Disciplina de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"volume-title":"Principles and Practice of Sleep Medicine","year":"2011","author":"M H Kryger","key":"ref1"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.5664\/jcsm.27657","article-title":"Polysomnographic findings are associated with cephalometric measurements in mouth-breathing children","volume":"5","author":"M L Juliano","year":"2009","journal-title":"J Clin Sleep Med"},{"volume-title":"International Classification of Sleep Disorders","year":"2014","author":"American Academy of Sleep Medicine","key":"ref3"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/08830738050200050101","article-title":"Cognitive dysfunction in children with sleep-disordered breathing","volume":"20","author":"L B Carvalho","year":"2005","journal-title":"J Child Neurol"},{"issue":"09","key":"ref5","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.sleep.2013.05.011","article-title":"Symptoms of sleep disorders and objective academic performance","volume":"14","author":"L B de Carvalho","year":"2013","journal-title":"Sleep Med"},{"issue":"01","key":"ref6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4181\/RNC.2014.22.930.11p","article-title":"Obstructive Sleep Apneaand Cardiovascular Diseases (Apneia Obstrutiva do Sono e Doen\u00e7as Cardiovasculares)","volume":"22","author":"D DA Campostrini","year":"2014","journal-title":"Revista Neuroci\u00eancias."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.csbj.2017.05.003","article-title":"Apolipoprotein E - 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