{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:50:44Z","timestamp":1771296644011,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of refractory epilepsy in these patients.<\/jats:p><jats:p>\n          Objective\u2003To evaluate the efficacy of everolimus in controlling refractory epilepsy in children with TS.<\/jats:p><jats:p>\n          Methods\u2003A literature review was conducted in the Pubmed, BVS, and Medline databases, using the descriptors Tuberous sclerosis, Children, Epilepsy, and Everolimus. Original clinical trials and prospective studies published in Portuguese or English in the last decade that evaluated the use of everolimus as an adjuvant therapy in the control of refractory epilepsy in pediatric patients with TS were included.<\/jats:p><jats:p>\n          Results\u2003Our search screened 246 articles from electronic databases, 6 of which were chosen for review. Despite the methodological variations between the studies, most patients benefited from the use of everolimus to control refractory epilepsy, with response rates ranging from 28.6 to 100%. Adverse effects were present in all studies leading to dropouts of some patients; however, the majority were of low severity.<\/jats:p><jats:p>\n          Conclusion\u2003The selected studies suggest a beneficial effect of everolimus in the treatment of refractory epilepsy in children with TS, despite the adverse effects observed. Further studies involving a larger sample in double-blind controlled clinical trials should be performed to provide more information and statistical credibility.<\/jats:p>","DOI":"10.1055\/s-0042-1758442","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:11:01Z","timestamp":1677802261000},"page":"392-398","source":"Crossref","is-referenced-by-count":3,"title":["Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-5781","authenticated-orcid":false,"given":"Catarina Ester Gomes","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-4472","authenticated-orcid":false,"given":"D\u00e9bora Lopes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1893-5547","authenticated-orcid":false,"given":"Erick Santos","family":"Nery","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0907-1572","authenticated-orcid":false,"given":"Evelin Duarte","family":"Serpa","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-7360","authenticated-orcid":false,"given":"L\u00e9cio Arag\u00e3o Souza","family":"Morais","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-1163","authenticated-orcid":false,"given":"Lucas Santana","family":"Dutra","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Departamento de Medicina, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-7325","authenticated-orcid":false,"given":"Marcos Baruch","family":"Portela Filho","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-0137","authenticated-orcid":false,"given":"Julieta Sobreira","family":"Goes","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia, Departamento de Ci\u00eancias da Vida, Salvador BA, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/abd1806-4841.20186972","article-title":"Tuberous sclerosis complex: review based on new diagnostic criteria","volume":"93","author":"L KL Portocarrero","year":"2018","journal-title":"An Bras Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0072-9752(07)87009-6","article-title":"Tuberous sclerosis","volume":"87","author":"P Curatolo","year":"2008","journal-title":"Handb Clin Neurol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/157015912804499537","article-title":"mTOR Inhibitors in Tuberous Sclerosis Complex","volume":"10","author":"P Curatolo","year":"2012","journal-title":"Curr Neuropharmacol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3906\/sag-2002-133","article-title":"Tuberous sclerosis: a review of the past, present, and future","volume":"50","author":"S P Uysal","year":"2020","journal-title":"Turk J Med Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2147\/TCRM.S145630","article-title":"Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives","volume":"15","author":"I E Overwater","year":"2019","journal-title":"Ther Clin Risk Manag"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ejpn.2018.05.006","article-title":"Management of epilepsy associated with tuberous sclerosis complex: Updated clinical recommendations","volume":"22","author":"P Curatolo","year":"2018","journal-title":"Eur J Paediatr Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev-genom-083118-015354","article-title":"Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex","volume":"20","author":"C L Salussolia","year":"2019","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1528-1167.2005.00266.x","article-title":"Tuberous sclerosis complex and the ketogenic diet","volume":"46","author":"E H Kossoff","year":"2005","journal-title":"Epilepsia"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1528-1167.2009.02397.x","article-title":"Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies","volume":"51","author":"P 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