{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:11Z","timestamp":1787004911590,"version":"build-2736575974"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Cognitive deficit in Parkinson disease (PD) is an important cause of functional disability in these patients and early detection, with sensitive instruments, can contribute to longitudinal monitoring.<\/jats:p>\n                  <jats:p>Objective\u2003To investigate the diagnostic accuracy, sensitivity, and specificity of the Addenbrooke's Cognitive Examination-III in patients with PD, using the comprehensive neuropsychological battery as reference method.<\/jats:p>\n                  <jats:p>Methods\u2003Cross-sectional, observational, case-control study. Setting: rehabilitation service. A total of 150 patients and 60 healthy controls matched for age, sex, and education. For level I assessment, Addenbrooke Cognitive Examination (ACE-III) was used. Level II assessment used a comprehensive neuropsychological battery of standardized tests for this population. All patients remained in on-state during the study. The diagnostic accuracy of the battery was investigated through the receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <jats:p>Results\u2003The clinical group was divided into 3 subgroups: normal cognition in Parkinson's disease (NC-PD-16%), mild cognitive impairment due to Parkinson's disease (MCI-PD-69.33%), and dementia due to Parkinson's disease (D-PD-14.66%). ACE-III optimal cutoff scores for detecting MCI-PD and D-PD were 85\/100 (sensitivity 58.65%, specificity 60%) and 81\/100 points (sensitivity 77.27%, specificity 78.33%), respectively. Age was inversely associated with the performance of the scores (totals and domains of the ACE-III), while the level of education had a significantly positive correlation in the performance of these scores.<\/jats:p>\n                  <jats:p>Conclusions\u2003ACE-III is a useful battery for assessing the cognitive domains and to differentiate individuals with MCI-PD and D-PD from healthy controls. Future research, in a community setting, is necessary to provide discriminatory capacity of ACE-III in the different severities of dementia.<\/jats:p>","DOI":"10.1055\/s-0042-1758448","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T19:11:01Z","timestamp":1677784261000},"page":"155-163","source":"Crossref","is-referenced-by-count":7,"title":["Addenbrooke's cognitive examination III: diagnostic utility for detecting mild cognitive impairment and dementia in Parkinson's disease"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-8020","authenticated-orcid":false,"given":"Nariana Mattos Figueiredo","family":"Sousa","sequence":"additional","affiliation":[{"name":"Rede SARAH de Hospitais de Reabilita\u00e7\u00e3o, Programa Reabilita\u00e7\u00e3o Neurol\u00f3gica, Salvador BA, Brazil."},{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6732","authenticated-orcid":false,"given":"Sonia Maria Dozzi","family":"Brucki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculdade de Medicina, Departamento de Neurologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","article-title":"Parkinson's disease","volume":"373","author":"A J Lees","year":"2009","journal-title":"Lancet"},{"issue":"12","key":"ref2","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson's disease","volume":"22","author":"M Emre","year":"2007","journal-title":"Mov Disord"},{"issue":"08","key":"ref3","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s10072-014-1666-z","article-title":"Neurofunctional correlates of attention rehabilitation in Parkinson's disease: an explorative study","volume":"35","author":"A Cerasa","year":"2014","journal-title":"Neurol Sci"},{"issue":"08","key":"ref4","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/mds.22506","article-title":"Cognitive impairment in Parkinson's disease: tools for diagnosis and assessment","volume":"24","author":"J Kulisevsky","year":"2009","journal-title":"Mov Disord"},{"issue":"02","key":"ref5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10072-017-3154-8","article-title":"Cognitive and behavioral disorders in Parkinson's disease: an update. 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